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Princeton Docket # 15-3076-1Researchers in the Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton University have discovered biomarkers that are indicative of oocyte quality. This invention is a new diagnostic tool for female reproductive status that will use biomarkers of oocyte quality to predict a...
Published: 2/14/2024
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Inventor(s): Coleen Murphy
Keywords(s): biomarker/diagnostic, female health, healthcare
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/30/2022
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies
Princeton Docket # 15-3064
Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets
host-pathogen interactions,...
Published: 2/14/2024
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Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
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Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Novel Cell Line for Hepatitis B Drug Discovery and Research
Princeton Docket # 15-3077
Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate...
Published: 2/14/2024
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Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals
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Polymer Janus Nanoparticles By Flash NanoPrecipitation
Princeton Docket # 14-2981
Janus particles are characterized by two physically distinct regions within or on the surface of the particle. Polymer Janus nanoparticles, in particular, contain at least two different polymer regions. At present, only a few ingenious routes for the generation of...
Published: 9/6/2022
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Inventor(s): Rodney Priestley, Robert Prud'homme, Chris Sosa
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, catalyst, Chemistry, drug delivery, Imaging
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Chemistry
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Integrated CMOS-based Single–chip Fluorescence Bio‐Sensor SystemDocket # 14-2990Integrated, low‐cost and portable point‐of‐care diagnostic technology has the potential to bring transformative changes in healthcare by enabling early detection of diseases in a remote field setting, allowing timely and rapid treatment to the patient and facilitating...
Published: 2/1/2024
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Inventor(s): Lingyu Hong, Kaushik Sengupta
Keywords(s): biomarker/diagnostic, computers/software, medical device, semiconductor
Category(s): Medical Devices/Diagnostics, Computer Science and Information Technology
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Noninvasive Mid-infrared in vivo Glucose Sensor
Princeton Docket # 14-2945
Researchers in the Department of Electrical Engineering at Princeton University have developed a novel, noninvasive method to measure blood glucose levels. Development of this noninvasive in vivo glucose sensor may improve the quality of life for the more than 343 million...
Published: 11/9/2022
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Inventor(s): Sabbir Liakat, Claire Gmachl, Anna Michel
Keywords(s): biomarker/diagnostic, diabetes, laser, life science research tools, medical device
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Mechanical/Electrical Engineering
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