|
Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/30/2022
|
Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
|
|
Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
|
Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
|
|
Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
|
Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
|
|
A Novel Assay for Sirtuin 4 (SIRT4) Lipoamidase Activity and the Activity of the Pyruvate Dehydrogenase Complex
Princeton Docket # 14-3002
A novel assay for measuring the lipoamidase activity of SIRT4 in mammalian cells and tissue samples has been created. A procedure by which the lipoamide cofactor activity can be monitored in mammalian cells has...
Published: 10/28/2022
|
Inventor(s): Thomas Shenk, Todd Greco, Ileana Cristea, Rommel Mathias, Adam Oberstein
Keywords(s): biologics, Biotechnology/Pharmaceuticals, genomics/proteomics (software), virology
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
|
|
Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
|
Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
|
|
Novel Cell Line for Hepatitis B Drug Discovery and Research
Princeton Docket # 15-3077
Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate...
Published: 2/14/2024
|
Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals
|
|
Polymer Janus Nanoparticles By Flash NanoPrecipitation
Princeton Docket # 14-2981
Janus particles are characterized by two physically distinct regions within or on the surface of the particle. Polymer Janus nanoparticles, in particular, contain at least two different polymer regions. At present, only a few ingenious routes for the generation of...
Published: 9/6/2022
|
Inventor(s): Rodney Priestley, Robert Prud'homme, Chris Sosa
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, catalyst, Chemistry, drug delivery, Imaging
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Chemistry
|
|
A New Enzyme and Process for Metabolic Engineering of Production of Sorbitol, Mannitol, Ribitol, Xylitol, Arabitol, Erythritol, and Other Polyols
Princeton Docket # 13-2939
Scientists in the Lewis-Sigler Institute, Princeton University have discovered an enzyme which encodes a broad-spectrum, D-stereoisomer-specific sugar alcohol phosphatase,...
Published: 9/26/2023
|
Inventor(s): Yi-Fan Xu, Joshua Rabinowitz, Fabien Letisse, Sarah Johnson
Keywords(s): biofuels, Biotechnology/Pharmaceuticals, Chemistry, metabolic engineering, model organism, yeast
Category(s): Biotechnology/Pharmaceuticals
|
|
Double-caged
GABA: A Novel Light-activated Probe
as a Neuroscience Research Tool
Princeton Docket #
13-2896-1
Researchers at Princeton University, Departments of Molecular
Biology and Chemistry, have developed a light-activated probe that can be used
as a neuroscience research tool.
Current methods of probing neural...
Published: 11/9/2022
|
Inventor(s): Diana Shi, Samuel Wang, Martin Semmelhack
Keywords(s): Biotechnology/Pharmaceuticals, Chemistry, CNS, life science research tools
Category(s): Biotechnology/Pharmaceuticals, Chemistry
|
|
Docket # 13-2834-1The market for biological microscopes is greater than $1 billion annually. There is a high demand in the biomedical research field for microscopes which are capable of resolving ever smaller features and faster dynamics in live cells. However, currently available biological microscopes are limited in their ability to follow phenomena...
Published: 12/12/2022
|
Inventor(s): Haw Yang, Kevin Welsher
Keywords(s): anti-infectives, anti-viral, Biotechnology/Pharmaceuticals, cancer/oncology, Imaging, life science research tools, microscopy, research tool
Category(s): Medical Devices/Diagnostics, Chemistry, Biotechnology/Pharmaceuticals
|