Search Results - bonnie+bassler

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A New Target for Pseudomonas aeruginosa Drug Discovery

A New Target for Pseudomonas aeruginosa Drug Discovery Princeton Docket # 21-3767Researchers in the Department of Molecular Biology, Princeton University have developed a novel method to quantify a physical interaction between the proteins called RhlR and PqsE from Pseudomonas aeruginosa, a globally important pathogen. The data show that RhlR-PqsE...
Published: 8/1/2022   |   Inventor(s): Bonnie Bassler, Isabelle Taylor, Jon Paczkowski
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Recombinant Phages for Targeted Bacterial Killing, Infection, Biodetection, and as a Means of Protein Extraction

Recombinant Phages for Targeted Bacterial Killing, Infection, Biodetection, and as a Means of Protein Extraction Princeton Docket # 19-3527 Researchers in Princeton University’s Department of Molecular Biology have developed a recombinant phage platform technology that can be easily and precisely engineered for particular disease applications....
Published: 1/13/2023   |   Inventor(s): Justin Silpe, Bonnie Bassler
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Trackable Quorum-Sensing Molecules for Diagnostic Applications

Princeton Docket # 17-3325-1High quality medical imaging technology has been one of most important developments in clinical care and personalized medicine. Pinpointing the source and cause of disease in a patient allows targeted and optimal treatment, saving time and money. Applying this type of imaging accuracy to the identification of bacterial pathogens...
Published: 12/21/2022   |   Inventor(s): Bonnie Bassler, Howard Stone, Min Kim, Aishan Zhao, Tom Muir
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Inhibiting Quorum Sensing of Bacteria in Healthcare and Industrial Devices Through Conjugation of Anti-Quorum Sensing Molecules to Surfaces

A surface-coating approach for bacteria-free health-care and industrial devices Docket # 15-3136 Bacteria frequently act as members of collectives to create surface-attached communities called biofilms and to synchronously activate the production of virulence factors. Bacterial group behaviors are regulated by a cell-cell communication process called...
Published: 9/8/2022   |   Inventor(s): Min Kim, Aishan Zhao, Howard Stone, Bonnie Bassler, Tom Muir
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Small Molecule Potentiation of Phage Antimicrobial Activity For Use in Medical, Industrial, Agricultural, and Food Safety Applications

Princeton Docket # 16-3239-1Researchers in the Department of Molecular Biology at Princeton University have developed an innovative therapy for the treatment of bacterial infections. The invention combines two unique discoveries to generate a novel, safe approach to combat bacterial infections without generating resistance. The first discovery is small...
Published: 12/21/2022   |   Inventor(s): Nina Hoyland-Kroghsbo, Jon Paczkowski, Bonnie Bassler
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Microfluidic Device for the Study and Treatment of Biofilm Formation in Environmental, Medical, or Industrial Devices

Methods and Microfluidic Device for the Study, Testing and Treatment of Biofilm Formation in Environmental, Medical, or Industrial Devices Docket # 13-2880Researchers at Princeton University have developed a microfluidic system and method to investigate biofilm morphologies under more realistic physical conditions which could be used to screen potential...
Published: 9/8/2022   |   Inventor(s): Bonnie Bassler, Howard Stone, Martin Semmelhack, Knut Drescher, Yi Shen, Colleen O'loughlin, Laura Miller Conrad
Keywords(s): antibiotics, anti-infectives, Biotechnology/Pharmaceuticals, life science research tools, medical device
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Novel Compounds for Treating Cholera and Other Infections: Potent Agonists of the Quorum Sensing Circuit

Princeton Dockets # 08-2418, 12-2775 & 12-2776 Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening disease. It is estimated that cholera affects 3-5 million people worldwide, and causes 100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and cotrimoxazole have been used to shorten the...
Published: 3/30/2022   |   Inventor(s): Martin Semmelhack, Bonnie Bassler, Lark Perez, Megan Bolitho, Matthew Koch, Wai-Leung Ng
Keywords(s): antibiotics, Biotechnology/Pharmaceuticals, small molecule
Category(s): Biotechnology/Pharmaceuticals

Resistant-Prone Small Molecule Anti-Bacterial Antagonists and Targets for Anti-Bacterial Drug Development

Princeton Docket # 08-2467 & 08-2486 Researchers at Princeton University, Department of Molecular Biology, have identified and synthesized small molecule antagonists that could serve as broad spectrum lead compounds for the disruption of quorum sensing in pathogenic Gram-negative bacteria. In proof of principle experiments, potent antagonist...
Published: 9/19/2022   |   Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals

Quorum Sensing: Cell-to-Cell Communication of Pathogenic Bacteria

Quorum Sensing is an essential form of intercellular communication used by many types of common bacteria, and many pathogenic bacteria use quorum sensing to attack and invade the human host. Quorum Sensing is used by bacteria to detect a critical cell number, which is the cell population required for pathogenic bacteria to release effective amounts...
Published: 9/26/2022   |   Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals