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Simple, Economical Bioseparation Technique Using Self-Cleaving Thermally Responsive Fusion Tags

Princeton Invention # 05-2188 Researchers in the Chemical Engineering Department at Princeton University have developed a new economical method for the purification of recombinant proteins expressed in E. coli and other expression host cells. This method relies on a self-cleaving elastin-like polypeptide (ELP) fusion...
Published: 7/3/2023   |   Inventor(s): David Wood, Mahmoud Banki
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Engineered In Vivo Biosensors for Nuclear Hormone Receptor Ligands

Princeton University Invention # 04-2095 Researchers in the Chemical Engineering Department at Princeton University have developed a new type of biosensor using Escherichia coli that can report ligand binding to eukaryotic nuclear hormone receptors. This system has been optimized to report the presence of endocrine-active compounds through...
Published: 2/14/2024   |   Inventor(s): David Wood, Georgios Skretas
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

New Simple, Economical Bioseparation Technique Using Self-Purifying, Self-Cleaving Affinity Tags

Princeton Invention # 04-2076 Researchers at Princeton University have developed a new economical method for the purification of recombinant proteins expressed in E. coli. In this method, the host cells simultaneously produce both an affinity tagged product protein and an easily recovered granular affinity carrier. The...
Published: 8/21/2023   |   Inventor(s): David Wood, Mahmoud Banki, Tillman Gerngross
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals