Search Results - drug+discovery

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Blocking bacterial infection by inhibiting surface-regulated virulence induction

Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 7/10/2015   |   Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 1/26/2015   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Voluntary Head Restraint and Automated In Vivo Imaging System

Voluntary Head Restraint and Automated in vivo Imaging System Princeton Docket #13-2837-1 Researchers at Department of Molecular Biology and the Princeton Neuroscience Institute, have developed a rat operated kinematic restraint clamp and automated in vivo imaging system. In neurosciences, measurement of neural activity in animals by imaging...
Published: 2/26/2013   |   Inventor(s): David Tank, Benjamin Scott, Carlos Brody
Keywords(s): CNS, drug discovery, Imaging, life science research tools
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

MiRNAs as Novel Therapeutics and Non-invasive Biomarkers for Bone Metastasis

Princeton Docket # 12-2807 Researchers in the Molecular Biology Department at Princeton University have discovered a group of miRNAs as novel therapeutics for bone metastasis. Through a series of in vitro and in vivo experiments, five distinctive miRNAs have been identified as inhibitors of osteoclast differentiation. Further, systemic treatment...
Published: 4/27/2012   |   Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules

Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl...
Published: 12/7/2011   |   Inventor(s): John (Jay) Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals

Inducing apoptosis in quiescent cells, a potential new therapeutic strategy for chemotherapy and the treatment of fibrotic disease

Princeton Docket # 11-2633 The ability to selectively kill quiescent cells could be a powerful tool in medicine. In particular, the ability to kill the quiescent tumor stem cells could be an important addition to our chemotherapeutic repertoire. A better understanding of the transition between quiescent and activated cellular states of fibroblasts...
Published: 12/5/2011   |   Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals

Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/1/2011   |   Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals

A Cell Line and Mouse Model for Studying Pathological TGFß Signaling during Cancer Progression and Metastasis in vivo

Princeton Invention # 07-2351 Cancer metastasis requires the intricate interactions between cancer cells and the host tissue microenvironment. Although TGFb signaling pathway has been implicated in breast cancer metastasis to bone and other target organs, the temporal-spatial requirement and the in vivo dynamics of TGFb signaling...
Published: 12/1/2011   |   Inventor(s): Yibin Kang
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals
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