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A method for measuring and modeling quantitative sequence-function relationships for possible applications in transcriptional misregulation, antibody optimization, and antigenic epitope development

Princeton University Invention # 10-2580 Researchers in the Physics and Molecular Biology Departments, Princeton University, have developed a method that uses a simple mutational assay and information theory to decipher the molecular mechanisms by which a biological sequence functions, either in vitro or in living cells. This technology was demonstrated...
Published: 3/30/2022   |   Inventor(s): Justin b. Kinney, Edward Cox, Curtis Callan, Anand Murugan
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

An Easy and Efficient Method for Engineering Large Synthetic Constructs into the Chromosome

Princeton University Invention # 10-2603 Researchers in the Department of Molecular Biology, Princeton University have developed an efficient, easy to use, two-step system for the site-directed insertion of large genetic constructs into arbitrary positions in the Escherichia coli chromosome. This system can also be used for the integration of...
Published: 3/30/2022   |   Inventor(s): Thomas Kuhlman, Edward Cox
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals