Search Results - john+(jay)+groves

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Human IDO1- Selective Agonists for Treating Autoimmune Disorders

IDO1 Selective Agonists for Treating Autoimmune Disorders Docket # 19-3557The Groves lab in the Department of Chemistry at Princeton University has identified a new pathway in suppressing immune responses which may lead to novel compounds for treating autoimmune diseases. Proof of concept and a lead compound have been identified allowing for the...
Published: 5/13/2021   |   Inventor(s): John (Jay) Groves, Micah Nelp
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Direct Route to Prepare Isocyanates via C-H Activation for Drug Discovery

Princeton Docket # 18-3374-1The first and only method for preparing high-valued aliphatic isocyanates via direct C-H activation has been developed by researchers at Princeton University. Organic isocyanates are versatile intermediates that provide access to a wide range of functionalities found in pharmaceuticals and agrochemicals. This method harnesses...
Published: 11/13/2017   |   Inventor(s): John (Jay) Groves, Xiongyi Huang, Thompson Zhuang
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water

Docket # 15-3063-1Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions without the input of external energy or the use of harsh chemicals, circumventing the major concerns of large-scale production...
Published: 6/9/2016   |   Inventor(s): John (Jay) Groves, Roy Xiao
Keywords(s): wastewater management
Category(s): Chemistry, Mechanical/Electrical Engineering

A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015

A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015 Princeton researchers in the department of chemistry together with colleagues at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School have developed the first...
Published: 6/30/2014   |   Inventor(s): John (Jay) Groves, Xiongyi Huang, Wei Liu, Jacob Hooker
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

An Efficient, Green Process for Cyanide Decontamination in Water

An Efficient, Green Process for Cyanide Decontamination in Water Princeton Docket # 14-2955 This innovation is an improvement to a previously patent pending process for the catalytic generation of chlorine dioxide, Princeton docket # 11-2630/2714, US Patent Publication 2013-0209573, “An Efficient, Catalytic and Scalable Method to Produce Chlorine...
Published: 1/9/2014   |   Inventor(s): John (Jay) Groves, Thomas Umile, Christina Chang
Keywords(s): catalyst, Chemistry, energy, green tech, wastewater management, water
Category(s): Chemistry

Selective Fluorination of Drug Molecules for Higher Potency, Improved Pharmacology and Lower Metabolic Burden

Princeton Docket # 12-2797/2758-1Chemists in the laboratory of Professor John T Groves, Princeton University have discovered a powerful, simple and potentially disruptive technology for drug diversification through direct fluorination (3D-F). Fluorine is a highly desirable drug component because replacement of hydrogen with fluorine usually results...
Published: 3/21/2013   |   Inventor(s): John (Jay) Groves, Wei Liu, Xiongyi Huang
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules

Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl...
Published: 12/7/2011   |   Inventor(s): John (Jay) Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals

Novel Metalloporphyrins and Related Metal Complexes for the Treatment of Oxidative Stress and Diseases with Oxidative Components

Princeton Invention # 99-1608 Researchers in the Chemistry Department at Princeton University have developed novel metalloporphyrins that offer new potential pharmaceuticals for the treatment of diseases such as diabetes, ischemia-reperfusion injury, stroke, inflammation, neurodegeneration, and sepsis in which active oxygen (ROS)...
Published: 12/1/2011   |   Inventor(s): John (Jay) Groves, Suzanne Moeller
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

A Novel Method of Interfering with Iron Uptake by Mycobacterium Tuberculosis and Related Organisms

Princeton Invention # 04-2103 Researchers in the Chemistry Department at Princeton University have discovered a novel pathway which may allow for a new pharmacological approach to the control of tuberculosis. The rational discovery of drugs requires prior knowledge of metabolic pathways. Usually this involves identifying the function...
Published: 12/1/2011   |   Inventor(s): John (Jay) Groves
Keywords(s): Chemistry
Category(s): Biotechnology/Pharmaceuticals

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water

Princeton Docket # 11-2630-1 Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions and without the input of external energy or use of harsh chemicals, circumventing the major concerns of...
Published: 11/22/2011   |   Inventor(s): John (Jay) Groves, Thomas Umile
Keywords(s):  
Category(s): Chemistry