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Inhibiting Bacteria Infection in Healthcare Devices through Surface Chemistry Treatments and Fluid Flow Control

Princeton Docket # 15-3109-1Researchers in the Departments of Molecular Biology and Mechanical and Aerospace Engineering at Princeton University have designed new methods to effectively inhibit the entry, spread and growth of bacteria. The entry of pathogenic bacteria into fluid-filled networks of the body causes serious infection and sepsis. In particular,...
Published: 12/21/2022   |   Inventor(s): Howard Stone, Zemer Gitai, Min Kim, Yi Shen, Albert Siryaporn
Category(s): Medical Devices/Diagnostics

Trackable Quorum-Sensing Molecules for Diagnostic Applications

Princeton Docket # 17-3325-1High quality medical imaging technology has been one of most important developments in clinical care and personalized medicine. Pinpointing the source and cause of disease in a patient allows targeted and optimal treatment, saving time and money. Applying this type of imaging accuracy to the identification of bacterial pathogens...
Published: 12/21/2022   |   Inventor(s): Bonnie Bassler, Howard Stone, Min Kim, Aishan Zhao, Tom Muir
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Inhibiting Quorum Sensing of Bacteria in Healthcare and Industrial Devices Through Conjugation of Anti-Quorum Sensing Molecules to Surfaces

A surface-coating approach for bacteria-free health-care and industrial devices Docket # 15-3136 Bacteria frequently act as members of collectives to create surface-attached communities called biofilms and to synchronously activate the production of virulence factors. Bacterial group behaviors are regulated by a cell-cell communication process called...
Published: 9/8/2022   |   Inventor(s): Min Kim, Aishan Zhao, Howard Stone, Bonnie Bassler, Tom Muir
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics