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Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/21/2022   |   Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals