Search Results - therapeutic

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Microfluidic Method for Continuous Production of Microfibers With Embedded Droplets

Microfluidic Method for Continuous Production of Microfibers with Embedded Droplets Princeton Docket #14-2982 Fibers are a useful medium for numerous applications, including drug delivery. Current technologies usually make fibers of homogeneous chemical composition or employ axial core-shell structures. To create more complex shapes and composition...
Published: 8/21/2018   |   Inventor(s): Howard Stone, Janine Nunes, Eujin Um, Tamara Pico
Keywords(s): drug delivery, life science research tools, regenerative medicine, research tool, soft scaffolds, therapeutic, tissue engineering, tissue repair, wound healing
Category(s): Medical Devices/Diagnostics

Blocking bacterial infection by inhibiting surface-regulated virulence induction

Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 7/10/2015   |   Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): anitbiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of ...
Published: 1/26/2015   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Novel Cell Line for Hepatitis B Drug Discovery and Research

Novel Cell Line for Hepatitis B Drug Discovery and Research Princeton Docket # 15-3077 Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate th...
Published: 1/14/2015   |   Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals

A Novel Adjuvant for Improved Immunological Stimulation

Princeton Docket # 14-3007 Researchers in the Department of Molecular Biology at Princeton University have isolated a mutant strain of Escherichia coli that is specifically more resistant to vancomycin than is its wild-type parent. The resistance mutation in this strain alters an enzyme normally involved in LPS biosynthesis causing it to synthesi...
Published: 6/9/2014   |   Inventor(s): Thomas Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
Keywords(s): anitbiotics, antibody, immunology, therapeutic, vaccines
Category(s): Biotechnology/Pharmaceuticals

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of Cellular Motility, Migration, and/or Invasion Princeton Docket # 13-2929-1 High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple ...
Published: 11/1/2013   |   Inventor(s): Hilary Coller, David Corney
Keywords(s): biomarker/diagnostic, cancer/oncology, life science research tools, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

MiRNAs as Novel Therapeutics and Non-invasive Biomarkers for Bone Metastasis

Princeton Docket # 12-2807 Researchers in the Molecular Biology Department at Princeton University have discovered a group of miRNAs as novel therapeutics for bone metastasis. Through a series of in vitro and in vivo experiments, five distinctive miRNAs have been identified as inhibitors of osteoclast differentiation. Further, systemic treat...
Published: 4/27/2012   |   Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Compstatin Variants as therapeutic leads for Autoimmune and Inflammatory Disease

Princeton University Invention # 09-2488 The present invention relates to a series of novel analogues to compstatin. Based on experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new analogues show greater binding affinity compared to native compstatin and are therefore potentially more potent drug candidates for diseases ...
Published: 12/1/2011   |   Inventor(s): Christodoulos Floudas (deceased) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis
Keywords(s): small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals

EGFR Inhibitors as Therapeutic Agents for Breast Cancer Bone Metastasis

Princeton University Invention # 09-2509 The involvement of the EGFR signaling pathway in bone metastasis has been implicated by a number of studies. However, the therapeutic significance by targeting EGFR signaling in the tumor-stroma interface has not been evaluated. Researchers in the Molecular Biology Department at ...
Published: 12/1/2011   |   Inventor(s): Yibin Kang, Xin Lu
Keywords(s): antibody, cancer/oncology, therapeutic
Category(s): Biotechnology/Pharmaceuticals

Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibiti...
Published: 12/1/2011   |   Inventor(s): A. James Link, Si Jia Pan
Keywords(s): anitbiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals