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Microfluidic Method for Continuous Production of Microfibers with Embedded Droplets
Princeton Docket #14-2982
Fibers are a useful medium for numerous applications, including drug delivery. Current technologies usually make fibers of homogeneous chemical composition or employ axial core-shell structures. To create more complex shapes and compositions,...
Published: 3/30/2022
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Inventor(s): Howard Stone, Janine Nunes, Eujin Um, Tamara Pico
Keywords(s): drug delivery, life science research tools, regenerative medicine, research tool, soft scaffolds, therapeutic, tissue engineering, tissue repair, wound healing
Category(s): Medical Devices/Diagnostics
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/30/2022
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
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Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Novel Cell Line for Hepatitis B Drug Discovery and Research
Princeton Docket # 15-3077
Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate...
Published: 2/14/2024
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Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 14-3007
Researchers in the Department of Molecular Biology at Princeton University have isolated a mutant strain of Escherichia coli that is specifically more resistant to vancomycin than is its wild-type parent. The resistance mutation in this strain alters an enzyme normally involved in LPS biosynthesis causing it to synthesize...
Published: 9/8/2022
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Inventor(s): Thomas Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
Keywords(s): antibiotics, antibody, immunology, therapeutic, vaccines
Category(s): Biotechnology/Pharmaceuticals
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Identification of Novel Isoforms of a Gene and
Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of
Cellular Motility, Migration, and/or Invasion
Princeton Docket # 13-2929-1
High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple mRNAs...
Published: 3/30/2022
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Inventor(s): Hilary Coller, David Corney
Keywords(s): biomarker/diagnostic, cancer/oncology, life science research tools, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Princeton Docket # 12-2807
Researchers
in the Molecular Biology Department at Princeton University have discovered a
group of miRNAs as novel therapeutics for bone metastasis. Through
a series of in vitro and in vivo experiments, five distinctive miRNAs have been
identified as inhibitors of osteoclast differentiation. Further, systemic
treatment...
Published: 3/30/2022
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Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Princeton
University Invention # 09-2488
The
present invention relates to a series of novel analogues to compstatin. Based on
experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new
analogues show greater binding affinity compared to native compstatin and are
therefore potentially more potent drug candidates for diseases related...
Published: 3/30/2022
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Inventor(s): Christodoulos Floudas (DECEASED) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis
Keywords(s): small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Princeton University Invention #
09-2509
The involvement of the EGFR signaling pathway in bone metastasis has been
implicated by a number of studies. However, the therapeutic significance by
targeting EGFR signaling in the tumor-stroma interface has not been evaluated.
Researchers in the Molecular Biology Department at Princeton...
Published: 3/30/2022
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Inventor(s): Yibin Kang, Xin Lu
Keywords(s): antibody, cancer/oncology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 11-2663
Researchers
at Princeton University created novel peptide derivatives of the antimicrobial
peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent
activity against Gram-negative bacteria. The most potent MccJ25 variants
displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/21/2022
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Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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