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Apoptosis or
programmed cell death is an essential process in the development and homeostasis
of all multi-cellular organisms such as humans. Suppression of programmed cell
death is a contributing reason for a range of human diseases such as
cancer. Thus finding a strategy to specifically down-regulate the
functions of Bcl-2 and Bcl-xL is...
Published: 2/24/2025
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Inventor(s): Yigong Shi
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Princeton University
Invention # 07-2348
Intramembrane proteolysis is a widely conserved regulatory mechanism in
species ranging from bacteria to humans. The first description of intramembrane
proteolysis came from the investigation of cholesterol homeostasis, where the ER
membrane-bound transcriptional factor SREBP must be cleaved by an...
Published: 2/24/2025
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Inventor(s): Yigong Shi, Nieng Yan
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Princeton University
Invention # 2174
Cancer is one of the most debilitating diseases affecting mankind. More
than 600 thousand patients die of cancer in the United States. Oncogenesis is
inhibited by the tumor suppressor genes and accelerated by oncogenes. p53 is one
of the most important tumor suppressor proteins and is inactivated in nearly...
Published: 3/30/2022
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Inventor(s): Yigong Shi
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Princeton University
Invention # 05-2166
Apoptosis or programmed cell death is an essential process in the
development and homeostasis of humans. Abnormal inhibition of apoptosis is a
hallmark of cancer and autoimmune diseases, whereas excessive activation of cell
death is implicated in neuro-degenerative disorders such as Alzheimer¿s...
Published: 3/30/2022
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Inventor(s): Yigong Shi
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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