Latest technologies from Princeton University

Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity in Disease Prediciton, Diagnosis and Treatment

jdrayton@princeton.edu — Mon, 29 Sep 2025 12:22:03 GMT

Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity in Disease Prediction, Diagnosis and Treatment Princeton Docket # 21-3806 Sequence is at the basis of how the genome and its variations shape chromatin organization, regulate gene expression, and impact traits and diseases. Epigenomic profiling efforts have enabled large-scale identification of regulatory elements with chromatin states, yet we lack methods to systematically predict regulatory activities from any sequence and thus predict the effects of any variant on these activities. ...

Predicting Genomic Variation Effects on Human Gene Transcription

jdrayton@princeton.edu — Mon, 29 Sep 2025 12:21:31 GMT

De novo prediction of tissue-specific expression effect and disease risk for every mutation in a human genome - Expecto Princeton Docket # 18-3423 Sequence-based models, with their scalability and usage of sequence dependencies, enable a new era of mutation analysis at unprecedented scale that can yield a new perspective on human variation in human diseases and complex traits. Researchers in the Department of Computer Science and the Lewis-Sigler Institute of Integrative Genomics at Princeton University and the Center for Computational Biology at the Flatiron Institute, a part of the...

DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequences

jdrayton@princeton.edu — Mon, 29 Sep 2025 12:20:06 GMT

DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequences Princeton Docket #s 18-3426, 18-3440 Researchers at Princeton University and Rockefeller University have collaborated to establish methods for the identification of de novo mutations in the vast noncoding genomic sequences. These methods, DeepSEA 2.0 and Seqweaver, use a novel deep learning framework to compare large datasets of regulatory sequences compiled from in vivo analyses with datasets of families affected by complex human diseases to pin...

Zeolite-Encapsulated Metal Nanoparticle Catalysts for Low-Temperature Methane Upgrading

jdrayton@princeton.edu — Thu, 18 Sep 2025 13:00:14 GMT

Zeolite-Encapsulated Metal Nanoparticle Catalysts for Low-Temperature Methane Upgrading Researchers developed a new catalyst using gold-palladium nanoparticles inside zeolite crystals to efficiently convert methane into valuable liquid chemicals at low temperatures, offering a more energy-efficient alternative to traditional methods. Background Natural gas, primarily composed of methane, is an abundant and relatively clean fossil fuel, but its utilization is often limited by the challenges of efficient conversion into value-added chemicals and fuels. Traditionally, the chemical industry upg...

Production of Spin-Polarized Molecular Beams via Microwave or Infrared Rotational Excitation

jdrayton@princeton.edu — Tue, 29 Jul 2025 09:44:14 GMT

Achieving high nuclear spin polarization in molecules is critical for enhancing the efficiency of nuclear fusion reactors and significantly boosting signals in nuclear magnetic resonance (NMR) and medical imaging. However, existing methods face substantial limitations in meeting the demand for large quantities of highly polarized molecules. Conventional techniques, including atomic beam sources, Stern-Gerlach separation, and spin-exchange optical pumping, are severely constrained by their microscopic production rates. Other approaches like Dynamic Nuclear Polarization (DNP) require the complex...

Spin-polarized fusion fuel with enhanced reactivity and isotropic emission

jdrayton@princeton.edu — Mon, 28 Jul 2025 12:08:03 GMT

Fusion reaction rates and the angular distribution of emitted products, such as neutrons and alpha particles, are significantly influenced by the spin states of the fuel nuclei, including deuterium, tritium, and helium-3. While the selective preparation of nuclei in specific spin states can enhance fusion reaction rates, this typically results in anisotropic emission patterns of fusion products. Such anisotropic emission poses several challenges for fusion reactor operation, including causing uneven particle flux and undesirable localized heating on fusion device walls, which can lead to mater...

Spin-Polarized Fuels for Enhanced Tritium Burn Efficiency in Fusion Energy Systems

jdrayton@princeton.edu — Mon, 28 Jul 2025 09:16:55 GMT

Magnetic confinement fusion power plants face a fundamental challenge in efficiently utilizing tritium fuel, a critical and limited resource. While increasing tritium burn efficiency (TBE)—the fraction of injected tritium that fuses—is desirable for fuel self-sufficiency and reducing inventory, existing approaches encounter an inherent trade-off: higher TBE leads to increased helium ash concentration in the core plasma. This ash dilutes the fuel, significantly reducing fusion power density and demanding higher energy confinement, thereby limiting overall plant performance. Conseque...

Active stabilization of parasitic fringes in optical spectrometers

jdrayton@princeton.edu — Wed, 14 May 2025 10:20:13 GMT

Active Etalon Stabilization for Precise Optical Spectrometer Performance (Princeton Docket #20-3680) Inventors: Gerard Wysocki, Chu Cheyenne Teng Optical spectrometers are critical in environmental monitoring, industrial process control, and chemical analysis, where precision is paramount. However, parasitic interference fringes (etalons) caused by temperature fluctuations, mechanical vibrations, or pressure changes degrade long-term stability and accuracy. Traditional solutions, such as indirect temperature stabilization using thermistors or heuristic signal processing, fail to...

Optical-Feedback-Stabilized Semiconductor Frequency Combs

jdrayton@princeton.edu — Wed, 14 May 2025 10:20:10 GMT

Optical-feedback-stabilized semiconductor frequency combs (Princeton Docket # 19-3580) Inventors: Gerard Wysocki, Jonas Westberg, Chu Teng The optical-feedback-stabilized semiconductor frequency comb is a breakthrough technology that dramatically enhances the stability and operational range of chip-scale laser frequency combs. By integrating a simple, external optical feedback mechanism, this innovation enables robust, low phase-noise comb operation without the need for complex device-level modifications or costly radio-frequency (RF) stabilization electronics. This optical-feedback-stabili...

Chirped Laser Dispersion Spectroscopy Sensitivity Booster

jdrayton@princeton.edu — Wed, 14 May 2025 10:20:07 GMT

Chirped Laser Dispersion Spectroscopy Sensitivity Booster (Princeton Docket # 16-3267) Inventors: Gerard Wysocki, Genevieve B. Plant, Yifeng Chen Laser-based gas sensing has entered a new era of precision with this innovative technology designed to overcome traditional sensitivity limitations. By integrating a local oscillator channel and advanced signal processing, this solution delivers unparalleled accuracy in detecting trace gases across industrial, environmental, and safety applications. This system splits a chirped laser beam into two arms: Sample Arm: Interacts with the target ga...

Fast Computational Phase and Timing Correction for Multiheterodyne Spectroscopy

jdrayton@princeton.edu — Wed, 14 May 2025 10:20:04 GMT

Fast Computational Phase and Timing Correction for Multiheterodyne Spectroscopy (Princeton Docket # 17-3351) Inventors: Gerard Wysocki, Jonas Westberg, Lukasz Sterczewski Digital phase and timing correction techniques address critical challenges in multiheterodyne and dual-comb spectroscopy by compensating for laser instabilities, enabling high-resolution measurements with cost-effective semiconductor lasers. These methods improve signal quality while reducing system complexity, making portable and real-time spectroscopic systems more feasible. Technical Approach The core innovat...

A device and method for path-integrated optical sensing and simultaneous retroreflector tracking using a multi-functional position-sensing photodetector

jdrayton@princeton.edu — Wed, 14 May 2025 10:19:56 GMT

Multifunctional optical sensor for simultaneous spectroscopic measurement and adaptive target tracking (Princeton Docket # 23-4045) Inventors: Gerard Wysocki, Michael Soskind, Felix Kleemann This invention is a multifunctional, open-path optical sensing system that enables simultaneous high-sensitivity spectroscopic measurement (specifically methane detection) and real-time tracking of a moving retroreflector (such as one mounted on a drone) using a single, commercially available quadrant photodetector (QPD). The sy...

Simultaneous Ranging and Remote Chemical Sensing Utilizing Optical Dispersion or Absorption Spectroscopy

jdrayton@princeton.edu — Wed, 14 May 2025 10:11:34 GMT

Simultaneous Ranging and Remote Chemical Sensing Utilizing Optical Dispersion or Absorption Spectroscopy (Princeton Docket # 14-3039) Inventors: Gerard Wysocki, Andreas Hangauer Princeton researchers have developed a novel methodology that enables simultaneous ranging and spectroscopic chemical detection, combining capabilities that are not achievable with current state-of-the-art continuous wave laser-based spectrometers. This system employs a continuous-wave laser modulated by a time-varying radio frequency signal to produce spectral sidebands that encode chemical spectral information an...

LIGHTWEIGHT OUT OF ORDER SCHEDULER FOR GPUs

jdrayton@princeton.edu — Mon, 14 Apr 2025 11:26:51 GMT

Lightweight Out of Order Scheduler for GPUs Princeton Docket # 24-4082-1 Graphics processing units (GPUs) accelerate parallel applications, such as machine learning and autonomous vehicles. Despite abundant parallelism in these applications, many programs still exhibit significant stalls. Previous proposals suggest adding out-of-order (OoO) execution to GPUs, but their high hardware overhead make them impractical. Princeton researchers have developed the first low-cost OoO execution mechanism for GPUs. Its OoO engine supports only the most performant and cost-effective aspects of OoO...

Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding

jdrayton@princeton.edu — Thu, 20 Feb 2025 08:40:09 GMT

Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding Princeton Docket # 19-3543-1 Reed-Muller (RM) codes are among the oldest families of error-correcting codes. Compared to polar codes, RM codes have the advantage of having a simple and universal code construction, though RM codes do not yet possess the generic analytical framework of polar codes (i.e., polarization theory). While it has been shown that RM codes achieve capacity on the Binary Erasure Channel (BEC) at a constant rate, as well as extremal rates for BEC and Binary Symmetric Ch...

Privacy-preserving AI over Next Generation Networks

jdrayton@princeton.edu — Thu, 20 Feb 2025 07:46:25 GMT

Privacy-preserving AI over Next Generation Networks Princeton Docket # 24-4056-1 Artificial intelligence (AI) is a key technology for next-generation networks; it will empower new functionalities to enable low-latency inference and sensing applications, including autonomous driving, personal identification, and activity classification (to name a few). Two conventional AI paradigms are commonly used in practice: 1) On-device inference which locally performs AI-based inference, which however suffers from high computation overhead, and 2) On-server inference, where edge devices upload their raw...

Viricidal Action of inhibition of telomerase action or inhibition of hTERT expression

jdrayton@princeton.edu — Mon, 17 Feb 2025 13:26:12 GMT

Viricidal Action of inhibition of telomerase action or inhibition of hTERT expression Princeton Docket: 23-4002-1 Treatment options remain limited for human cytomegalovirus (HCMV), a double-stranded DNA herpesvirus with acute and chronic pathogenic effects as well as the potential to impact cancer progression. While several anti-viral drugs attenuate active infection, unmet need remains given that efficacy is limited, viral resistance is significant, and there is no existing method to permanently eradicate HCMV from the human host. As a result, once infected by HCMV, humans are infected for ...

Training neural networks with a hybrid optimization method of genetic and gradientdescent algorithms

jdrayton@princeton.edu — Tue, 07 Jan 2025 09:13:29 GMT

Training Neural Networks with a Hybrid Optimization Method of Genetic and Gradient Descent Algorithms Princeton Docket # 25-4214 Neural networks are a powerful class of machine learning model that learn to perform useful operations such as classification, inference, and generation, and can be applied to a range of tasks, such as analysis and generating text, code, or images. Training these models, however, requires exponentially increasing amounts of data and computational power; they are also notoriously difficult to successfully optimize, potentially requiring several training attempts to ...

A New Dopant for Iron (II) Oxide-Based Solar Energy Conversion Devices: Enhanced Conductivity and Low Cost

jdrayton@princeton.edu — Wed, 11 Dec 2024 10:57:53 GMT

Princeton Docket # 12-2823 Solar energy conversion devices include photovoltaics, photoelectrochemical cells and photocatalysts, which convert the energy of sunlight into electricity and produce fuels from carbon dioxide and water. Different materials for making the solar energy conversion devices exhibit different energy conversion efficiencies and entail different costs. Currently, the most prevalent semiconductor material used in the solar industry is (poly)crystalline silicon for photovoltaics, which requires an expensive purification process to obtain pure and...

HIGH OUTPUT, FLEXIBLE PIEZOELECTRIC DEVICES

jdrayton@princeton.edu — Wed, 11 Dec 2024 10:47:20 GMT

Princeton Docket # 10-2585 Researchers at Princeton have developed a new design for highly flexible, high output piezoelectric assemblies. Princeton is seeking an industrial partner to commercialize this technology. Current and past devices have relied on low output piezoelectric compounds and mechanical linkages in an attempt to perform a similar function. &n...

A Device for Harvesting Mechanical Energy Through a Piezoelectrochemical Effect

jdrayton@princeton.edu — Wed, 11 Dec 2024 08:13:03 GMT

Princeton Docket # 15-3135-1 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have developed a piezoelectrochemical device which uses mechanical stress to produce a voltage/current. Mechanical energy harvesting is an increasingly important method of providing power to distributed sensor networks where physical connection to a power source is impractical. Conventional methods use vibrations to actuate a piezoelectric element, coil/magnet assembly, or capacitor plates, thereby generating an electric current. The low charge-density of these d...

Superconducting WS2-based nanosheet ink for printable and flexible electronics

jdrayton@princeton.edu — Wed, 11 Dec 2024 07:55:01 GMT

Superconducting WS2-based nanosheet ink for printable and flexible electronics Princeton Docket # 22-3910-1 Researchers at Princeton University have developed a novel printable nanosheet ink that represents a significant advancement in nanomaterial technology. Previous research in 2D material inks has primarily focused on graphene-based solutions, which have shown promise but often struggles with stability, conductivity, or substrate compatibility issues. This ink's unique composition, which consists of atomically thin 2D materials with large surface areas, ensures exce...

Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks

jdrayton@princeton.edu — Wed, 11 Dec 2024 07:41:30 GMT

Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks Princeton Docket # 25-4192-1 Princeton University researchers have developed an innovative hardware solution known as Random and Safe (RaS) caches to address critical security vulnerabilities in modern computer systems. This technology significantly enhances security by effectively preventing side-channel and speculative execution attacks that exploit cache timing channels. Unlike current hardware security proposals, which often partition hardware resources, leading to scalability issues, RaS caches maintain high perform...

mmWall: A Reconfigurable Metamaterial Surface for mmWave Networks

jdrayton@princeton.edu — Fri, 22 Nov 2024 07:01:08 GMT

mmWall: A Reconfigurable Metamaterial Surface for mmWave Networks Princeton Docket # 21-3796 As mobile operators transition to 5G networks, the integration of millimeter wave (mmWave) technology into indoor environments presents significant challenges. High directionality and susceptibility to blockage from obstacles like walls and human movement can severely hinder signal reliability. To overcome these issues, Princeton University researchers developed the mmWall, an innovative wall-mounted smart meta surface. This cutting-edge solution enables efficient beam relaying through walls, directi...

Segmented Planar Stellarator Coils

jdrayton@princeton.edu — Tue, 19 Nov 2024 10:31:57 GMT

Non-Confidential Brief Segmented Planar Stellarator Coils Princeton Docket # 25-4189-1 Researchers at the Princeton Plasma Physics Laboratory propose a novel configuration of stellarator fusion reactor coils. Traditional stellarator coils incorporate a complex, non-planar design in order to magnetically confine the plasma in a specified equilibrium. This leads to numerous engineering challenges in a complex manufacturing process. The inventors describe a previously unexplored coil configuration of two planar curves joined at break points. The simpler geometry of these coils presents...

LWIR Transparent Multilayer Optical Metamaterials for Canopies and Roofs

jdrayton@princeton.edu — Mon, 04 Nov 2024 08:28:05 GMT

Optical Metamaterials for Canopies and Roofs Princeton Docket #23- 4032/4035 Researchers at Princeton University’s Department of Civil and Environmental Engineering developed an innovative cooling technology to revolutionize urban heat management by using a novel roof design with unique thermal and optical properties. This is accomplished with a optical metamaterial which reflects sunlight and removes heat from the interior of the building faster than traditional roofing materials and architectures. The solution’s passive nature eliminates the need for energy-intensive air condit...

AutoPersuade: A framework for generating, evaluating and, revising arguments

jdrayton@princeton.edu — Mon, 04 Nov 2024 06:54:41 GMT

AutoPersuade: A framework for generating, evaluating and, revising arguments Princeton Docket # 24-4141-1 AutoPersuade is an innovative framework for generating, evaluating, and refining persuasive arguments. This technology offers a comprehensive solution for organizations and individuals seeking to create more effective messaging across various domains, including marketing, politics, and public health campaigns. Its ability to identify persuasive elements and predict the effectiveness of new arguments makes it a valuable tool for any organization looking to optimize its communication ...

Microlens Amplitude Masks for Flying Pixel Removal in Time-of-Flight Imaging

jdrayton@princeton.edu — Mon, 04 Nov 2024 06:33:55 GMT

Microlens Amplitude Masks for Flying Pixel Removal in Time-of-Flight Imaging Princeton Docket # 21-3789 Flying Pixels (FPs) are common artifacts in time-of-flight (ToF) imaging that arise at object boundaries, where light from both foreground and background is mixed, leading to inaccurate depth measurements and negatively impacting 3D vision tasks. The Mask-ToF approach addresses this issue by learning a microlens-level occlusion mask that customizes the sub-aperture for each sensor pixel. This mask modulates the integration of foreground and background light on a per-pixel basis, effectivel...

Quantum device using insulating topological material

jdrayton@princeton.edu — Mon, 21 Oct 2024 07:28:16 GMT

Quantum device using insulating topological material Princeton Docket # 24-4093-1 Current quantum electronic devices often rely on conducting materials, which can limit their efficiency and scalability due to energy loss and interference from bulk conducting states. Princeton researchers have made a significant breakthrough in this field by developing a novel nanoelectronic device using insulating topological material that exhibits quantum coherence. For the first time, this team has successfully fabricated Bi4Br4 crystals that demonstrate the Aharonov-Bohm effect in an insulating ma...

Methods for data multiplexing in neural networks

jdrayton@princeton.edu — Mon, 21 Oct 2024 07:11:57 GMT

Methods for data multiplexing in neural networks Princeton Docket # 22-3898-1 Current neural network architectures, particularly Transformers, face significant challenges due to their GPU-memory intensity, which limits throughput and increases time and energy costs during training and deployment. To address this issue, Princeton University researchers have developed an innovative method that leverages multiplexing to enhance neural network efficiency. This technique allows models to process multiple input instances simultaneously through a combined vector representation in a single forward p...

Identification Procedure of Room-Temperature Quantum Spin Hall Topological Edge State

jdrayton@princeton.edu — Mon, 21 Oct 2024 06:35:40 GMT

Identification Procedure of Room-Temperature Quantum Spin Hall Topological Edge State Princeton Docket # 24-4088 This groundbreaking technology represents the first realization of room temperature topological states, a significant advancement in the field of quantum materials. Topological insulators, known for their insulating bulk and conducting surface states, have long been limited by the need for extremely low temperatures. This innovation overcomes that barrier, enabling practical applications in consumer electronics without complex cooling systems. The technology provides a ro...

Development of a dual channel detection system for pan-genotypic simultaneous quantification of hepatitis B and delta viruses

jdrayton@princeton.edu — Wed, 09 Oct 2024 11:35:57 GMT

Development of a dual channel detection system for pan-genotypic simultaneous quantification of hepatitis B and delta viruses Princeton Docket: 24-4106-1 Hepatitis B virus (HBV) remains a major public health problem, causing chronic infection in at least 257 million people who are at risk of developing severe liver disease, including fibrosis, cirrhosis, and liver cancer (hepatocellular carcinoma, HCC). Approximately 12 – 72 million HBV carriers are co-infected with hepatitis delta virus (HDV), a small satellite virus of HBV that can only propagate in the presence of HBV ...

Cumene to phenol conversion through bromine radicals generated via visible light

jdrayton@princeton.edu — Tue, 08 Oct 2024 09:13:19 GMT

Cumene to phenol conversion though bromine radicals generated via visible light Princeton Docket # 24-4112-1 Phenol is a vital organic compound widely used in various industries, including plastics, pharmaceuticals, and agrochemicals. Researchers at Princeton University have developed a groundbreaking method for generating phenols from cumene that addresses significant limitations of traditional conversion processes. Conventional methods, which are typically reliant on high temperatures and pressures, lead to substantial energy consumption, low yields, and unwanted by-products. The new appr...

Peak Electric Load Prediction

jdrayton@princeton.edu — Mon, 30 Sep 2024 11:11:53 GMT

Peak Electric Load Prediction Princeton Docket # 24-4155-1 In today's energy landscape, commercial and industrial users face escalating peak demand charges, which can significantly impact their operating costs. These charges, determined by the highest levels of energy consumption during peak periods, can account for 10% to 40% of a customer's electricity bill, as established by the Federal Energy Regulation Commission (FERC). Companies often struggle to predict peak demand times, typically relying on external consultancy forecasts that can be limited in accuracy and timeliness. This...

Tube Heating System for Drying a Liquid Cell

jdrayton@princeton.edu — Mon, 30 Sep 2024 11:06:43 GMT

Tube Heating System for Drying a Liquid Cell Princeton Docket # 25-4187 This innovative tube heating system developed by researchers at Princeton University represents a significant advancement in liquid phase transmission electron microscopy (TEM) technology. Previous systems have struggled with prolonged downtime, which limits productivity and the ability to conduct in situ experiments. However, this new design efficiently heats gas flow from 68 to 130 °F, effectively drying liquid cells assembled on liquid phase TEM holders in just 2 hours, which is far superior to the 48 hour...

Jet Assisted Wet Spinning of Photopolymerizable Material

jdrayton@princeton.edu — Thu, 19 Sep 2024 07:15:08 GMT

Jet Assisted Wet Spinning of Photopolymerizable Material Princeton Docket # 22-3931-1 Jet Assisted Wet Spinning (JAWS), an innovative fiber manufacturing technology developed by Princeton University researchers, offers unparalleled control and versatility in producing photopolymerized fibers. The process enables precise diameter tuning, allowing for the creation of fibers ranging from hundreds of microns down to less than 10 microns, providing exceptional flexibility for diverse applications. This unique photopolymerization method eliminates common clogging issues and is a major improvement ...

Recycling Commercial Black Polystyrene Plastic to Monomer Using Photothermal Conversion

jdrayton@princeton.edu — Wed, 18 Sep 2024 12:59:01 GMT

Recycling Commercial Black Polystyrene Plastic to Monomer Using Photothermal Conversion Princeton Docket # 24-4131 Previous recycling technologies have struggled to effectively process black plastics due to their stability and the presence of additives that complicate sorting and recycling. As a result, the recycling rate for these materials has been nearly zero. To solve this environmental challenge, Princeton University researchers have developed an innovative process that leverages photothermal conversion to depolymerize polystyrene plastics, utilizing the pigment already present in black...

Method to control and manipulate floating water droplets

jdrayton@princeton.edu — Wed, 18 Sep 2024 10:59:17 GMT

Method to control and manipulate floating water droplets Princeton Docket # 24-4117-1 This new technology developed by researchers at Princeton University represents a significant advancement in the field of interfacial self-assembly and droplet manipulation. Previous technologies in this area have been limited in their ability to precisely control droplet behavior and interactions. However, this technology offers simple and easy to implement methods for both active and passive manipulation of drops at the interface, providing unprecedented control over droplet behavior. This system ...

Single-Torus-Liquid-Metal-Coil fusion device to obtain all stellarator and tokamak configurations

jdrayton@princeton.edu — Thu, 09 May 2024 06:43:06 GMT

Non-Confidential Brief Single-Torus-Liquid-Metal-Coil Fusion Device to Obtain All Stellarator and Tokamak Configurations Princeton Docket # 24-4079-1 Researchers at the Princeton Plasma Physics Laboratory (PPPL) have proposed a method for the design of fusion devices (tokamaks and stellarators) that achieve magnetic confinement of plasmas with electromagnetic coils made of a single torus coil. Torus single coil design allows archiving all the possible magnetic field configurations which is very useful for comparing the performance of different stellarators. The conductive torus itse...

Synthetic opine mutualism for enhancement of beneficial plant-microbe interactions

jdrayton@princeton.edu — Tue, 05 Mar 2024 11:08:16 GMT

Synthetic opine mutualism for enhancement of beneficial plant-microbe interactions Princeton Docket #23-4015 Description Inventors in Princeton’s Department of Chemical & Biological Engineering have developed a novel plant-microbe system that improves the persistence of beneficial bacteria at the root-soil interface of crops. Plant growth-promoting rhizobacteria (PGPR) are microorganisms that improve plant growth, stress tolerance, and disease resistance without the use of applied chemicals. Existing PGPR technologies are difficult to insert in existing soil micr...

Quench Protection of Superconducting Coils using Inductively Coupled Conductors

jdrayton@princeton.edu — Thu, 19 Oct 2023 10:40:12 GMT

Quench Protection of Superconducting Coils using Inductively Coupled Conductors Princeton Docket # 24-4076-1 Inventors at PPPL have conceived an invention focused on the protection of high-temperature superconducting (HTS) electromagnets. The innovation hinges on an integrated design method that employs inductively coupled normal-conducting elements embedded within the HTS coil winding. During a quench event, when the superconducting current decreases rapidly, the embedded conductor is induced with current, facilitating uniform propagation of the quench and effectively protecting the superco...

Ironless Linear Induction Motor Actuator for Magnetic Field Environment

jdrayton@princeton.edu — Wed, 30 Aug 2023 09:09:20 GMT

Non-Confidential Brief Ironless Linear Induction Motor Actuator for Magnetic Field Environment Princeton Docket # 23-3984-1 Researchers at the Princeton Plasma Physics Laboratory have proposed an invention that allows use of a linear induction motor in the presence of a strong magnetic field. Standard electric motors and actuators will not work in a strong magnetic field environment due to the presence of the magnetic field. This novel design of a linear induction motor allows the electrically driven actuator to be used in the presence of a magnetic field. In addition, friction between the ...

Method for Reinforcement, Quench Protection, and Stabilization of Large All-Metal Superconducting Magnets [PPPL No. M-1054]

jdrayton@princeton.edu — Thu, 17 Aug 2023 13:46:19 GMT

Non-Confidential Brief Method for Reinforcement, Quench Protection, and Stabilization of Large All-Metal Superconducting Magnets Princeton Docket # 24-4066-1 Inventors at the Princeton Plasma Physics Laboratory (PPPL) have developed a novel technology with significant advantages in the design and protection of high temperature superconducting (HTS) coils. The primary existing method of quench detection of HTS coils uses fiber optics. Due to the extremely slow normal zone propagation speed in yttrium barium copper oxide (YBCO) tape and other high temperature superconductors, the fib...

Confocal Laser Induced fluorescence diagnostic with annular laser beam for large focal distances

jdrayton@princeton.edu — Fri, 23 Jun 2023 08:31:15 GMT

Non-Confidential Brief Confocal Laser Induced Fluorescence Diagnostic With Annular Laser Beam for Large Focal Distances Princeton Docket # 23-4006-1 Laser induced fluorescence (LIF) is routinely used for characterization of plasma sources or in gas dynamic applications. Conventional LIF techniques require access to studied volume from two sides: for the laser beam injection and in perpendicular direction for the fluorescence emission collection. This limits the applicability of these techniques in some cases, as it is not possible to provide the required optical access. Confocal LIF design,...

3D Printed Active Electronic Materials and Devices

jdrayton@princeton.edu — Thu, 30 Mar 2023 08:33:15 GMT

Princeton Docket # 15-3114-1 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have patented the 3D printing of active (semiconductor) electronic materials and devices, based on an extrusion process. The technique allows for printing of devices on flexible sheets, over large areas, in horizontal and vertical configurations, in three-dimensional shapes, and on arbitrary 3D (non-flat) surfaces, for a variety of applications. In addition to 3D printing semiconductors, the technique includes printing piezoelectric, superconducting, and ferroele...

Variable Radii Bitter Spiral Crystal Spectrometer

jdrayton@princeton.edu — Thu, 05 Jan 2023 11:50:15 GMT

Variable Radii Bitter Spiral Crystal Spectrometer Princeton Docket #22-3922-1 A novel high-resolution x-ray spectrometer for small or point-like emission sources has been developed using a crystal shape having both a variable major and minor radius of curvature. This variable-radii spiral spectrometer (VR-Spiral) allows five key spectrometer design goals to be achieved simultaneously: High spectral (energy) resolution High throughput Broad energy range Reduction of source size broadening 1D spatial imaging This novel shape provides near perfect imaging of a point-source ...

DNA Valency Sorting Chromatography for Separating Large Solutes

jdrayton@princeton.edu — Thu, 04 Aug 2022 09:42:07 GMT

DNA Valency Sorting Chromatography for Separating Large Solutes Princeton Docket # 22-3863 Few technologies are available for analyzing or purifying, in a general way, large solutes labeled with a defined number of molecules. Large solutes could be organic or inorganic nanoparticles, large macromolecules, assemblies of macromolecules or nanoparticles, viruses, drug and vaccine delivery nanovesicles, to name a few. Researchers at Princeton University’s Department of Chemistry have developed DNA valency sorting chromatography, a new method for separating large solutes based ...

New biological method for producing semiconductor quantum dots using de novo proteins

jdrayton@princeton.edu — Wed, 15 Jun 2022 11:01:01 GMT

New biological method for producing semiconductor quantum dots using de novo proteins Princeton Docket # 22-3839 Quantum dots are an emerging technology with applications in electronics, quantum computing, and biology research. Several methods exist for manufacturing quantum dots, varying in efficacy and end product. Most manufacturing processes are contaminating processes that often utilize heavy metals. For bio-compatible quantum dots, traditional synthesis methods can’t be used as they rely on toxic precursors that are difficult or impossible to remove. Researchers a...

A Quantitative Screen for the Assessment of Microbiome Derived Drug Metabolism

jdrayton@princeton.edu — Wed, 27 Apr 2022 12:42:19 GMT

MDM-QScreen: A Quantitative Screen for the Assessment of Microbiome Derived Drug Metabolism for Drug Development and Personalized Medicine Princeton Docket # 20-3681 The human gut microbiome is composed of hundreds of individual species of bacteria and varies greatly between individuals. It has been shown for more than 70 years that bacterial isolates from the gut microbiome can directly metabolize clinically used drugs, with important clinical implications (e.g., effects on toxicity or therapeutic efficacy). Despite this knowledge, the exact contribution of the gut microbiome...

Spheromak Gun for Inductive flux Injection

jdrayton@princeton.edu — Mon, 11 Apr 2022 09:35:32 GMT

Spheromak Gun for Inductive flux Injection Princeton Docket # 22-3902 PPPL and a collaborator have proposed the formation of a high flux spheromak by an inductive flux injection coaxial gun. The basic approach of the scheme is based on a principle in which plasmas relax toward the minimum energy state during spheromak formation, independent of initial conditions. Inductive formation of a spheromak was demonstrated 40 years ago by Yamada et al, PRL 1981 by utilizing a relaxation process towards the Taylor minimum energy state using flux-core-based spheromak formation. Proposed is a formation ...

Optical Counting and Localization of Suspended Particles Using a Hough Transform

jdrayton@princeton.edu — Mon, 04 Apr 2022 06:54:52 GMT

Optical Counting and Localization of Suspended Particles Using a Hough Transform Princeton Docket # 20-3689 Researchers at Princeton University and PPPL have developed a new method for counting bubbles in non-electronic, superheated emulsion bubble neutron detectors. Traditional single-image counting techniques lose accuracy as objects occlude one another at higher densities. By combining the bubble position data of multiple images, this technology overcomes the occultation limit from previous imaging methods and can identify the unique identity and three-dimensional location of the bu...

Debris mitigation in laser produced plasmas using three-dimensional manipulation of magnetic topology

jdrayton@princeton.edu — Mon, 04 Apr 2022 06:15:46 GMT

Debris Mitigation in Laser Produced Plasmas Using Three-Dimensional Manipulation of Magnetic Topology Princeton Docket # 20-3704 Moore's law dictates that computer chips become ever smaller. The devices that fabricate these chips are facing constraints governed by fundamental physics. In order to achieve small chip size, the next generation of photolithography devices uses extreme ultraviolet (EUV) in order to produce smaller components. EUV is generated using laser produced plasma consisting of vaporizing tin droplets thousands of times a second with high powered lasers. This metho...

Permanent Magnet Stellarator Design

jdrayton@princeton.edu — Wed, 30 Mar 2022 15:52:12 GMT

Novel Stellarator Design Princeton Docket # 21-3827 / 3821 / 3822 Procedure for Designing Arrays of Permanent Magnets PPPL inventors have developed a novel procedure for designing an array of magnets for confining stellarator plasmas using a small number of unique magnet parts. The parts consist of identically shaped cubes, each of which is polarized along one of as few as three unique orientations. The procedure has been shown to arrive at solutions in which the surface-averaged relative normal component of the magnetic field on the plasma boundary is well below 1%, satisfying physics requi...

Low-Temperature Plasma Device for Sterilization and Anti-Viral Applications (PPPL)

jdrayton@princeton.edu — Wed, 30 Mar 2022 11:04:54 GMT

Low Temperature Plasma Device for Sterilization and Antiviral Applications Princeton Docket # 20-3699 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a flexible dielectric-barrier discharge (DBD) device which produces a uniform, cold plasma for disinfection and sterilization. The device can easily be made into desirable geometries for a multitude of applications. Cold plasma from DBD devices has been previously shown to have beneficial biological effects and promote significant killing of bacteria and virus inactivation without inducing thermal...

A rocket thruster that could take humans to Mars and beyond

jdrayton@princeton.edu — Wed, 30 Mar 2022 09:33:53 GMT

A rocket thruster that could take humans to Mars and beyond Docket: 21-3746-1 A new type of rocket thruster propels a spacecraft by taking advantage of the physical mechanism that accelerates solar flares. The thruster would apply magnetic fields to force particles of electrically charged gas, or plasma, to shoot out the back of a rocket at high velocity, causing forward momentum. The new thruster would propel a spacecraft far more efficiently than currently available plasma thrusters, which use electric fields to propel particles. That higher efficiency could bring the outer planets within...

Metabolomics Explorer (MetEx) for Cryptic Natural Products or Antibiotic Drug Discovery

jdrayton@princeton.edu — Wed, 08 Dec 2021 11:54:06 GMT

Metabolomics Explorer (MetEx) for Cryptic Natural Product or Antibiotic Drug Discovery Princeton Docket # 22-3873 Researchers in Princeton University’s Department of Chemistry have developed Metabolomics Explorer (MetEx), an application for the analysis of parallel liquid chromatography-coupled mass spectrometry (LC-MS)-based metabolomics data. MetEx is a highly interactive application that facilitates visualization and analysis of complex metabolomics datasets, consisting of features described by retention time, m/z, and MS intensity, as a function of hundreds of conditi...

A New Target for Pseudomonas aeruginosa Drug Discovery

jdrayton@princeton.edu — Tue, 02 Nov 2021 08:39:36 GMT

A New Target for Pseudomonas aeruginosa Drug Discovery Princeton Docket # 21-3767 Researchers in the Department of Molecular Biology, Princeton University have developed a novel method to quantify a physical interaction between the proteins called RhlR and PqsE from Pseudomonas aeruginosa, a globally important pathogen. The data show that RhlR-PqsE interaction is required for the bacterium to be virulent. Thus, targeting such proteins or their interaction could be leads for antimicrobial drug development. Additionally it would also be possible to use this method to repor...

Hand Sanitizer Gels from Sustainable Resources for Various Skin Types

jdrayton@princeton.edu — Mon, 01 Nov 2021 13:08:24 GMT

Developing sustainable approaches to produce consumer materials is one of the promising routes to effectively reduce carbon footprint. During unpresented situations, for example COVID-19 global pandemic, consumer materials such as hand sanitizer gels become strategic products with a global high demand. Current technologies in producing such gels require at least 5 components and may go up to 10 in some cases. In addition, due to the usage of these petroleum-based components, the formulation and production process of hand sanitizer gels becomes inflexible and limited to small scale productions ...

Method of Assessing Bacterial Viability on Low Biomass Environments

jdrayton@princeton.edu — Thu, 28 Oct 2021 07:14:59 GMT

Method of Assessing Bacterial Viability on Low Biomass EnvironmentsPrinceton Docket # 22-3843 Researchers in the Department of Molecular Biology, Princeton University have developed a novel method of assessing bacterial community viability. This highly reliable and accurate method allows for the assessment of extremely low biomass samples, which cannot be done with traditional methods such as qPCR. Using the commercially-available small molecule propidium monoazide (PMA), together with droplet digital PCR (PMA-ddPCR), this method allows for very accurate quantification of DNA even...

C. elegans retrotransposon Cer1 as a Delivery Mechanism for RNA-based Therapeutics

jdrayton@princeton.edu — Wed, 29 Sep 2021 08:22:43 GMT

C. elegans retrotransposon Cer1 as a delivery mechanism for RNA-based TherapeuticsPrinceton Docket # 22-3838 Researchers in Princeton University’s Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton University have identified that Cer1 is responsible for carrying a small RNA-mediated signal from germline tissue to neurons, resulting in changed behavior (avoidance of pathogens) in C. elegans. Additionally, Cer1 can be secreted into media, and this media is sufficient to transfer learned information to naïve animals. Unlike v...

Glycopeptide Antibiotic Combination Therapy Against Clostridial Infections, In Particular, C difficile

jdrayton@princeton.edu — Fri, 24 Sep 2021 10:53:24 GMT

Glycopeptide Antibiotic Combination Therapy Against Clostridial Infections, In Particular, C. difficile Princeton Docket # 21-3813 Researchers in the Department of Chemistry, Princeton University, and the Department of Chemistry, Emory University, have identified that when combined, vancomycin and keratinicyclin B interact synergistically to inhibit the growth of C. difficile at concentrations up to 8-fold lower than their respective minimal inhibitory concentrations. Keratinicyclin B represents a new glycopeptide antibiotic chemotype with a novel mechanism of acti...

CeLab: A Miniature Easy to Use C. elegans Lab on a Chip for Research

jdrayton@princeton.edu — Thu, 16 Sep 2021 06:11:05 GMT

CeLab: A Miniature Easy to Use C. elegans Lab-on-chip for Research Princeton Docket # 22-3844 Researchers in Princeton University’s Department of Molecular Biology have developed a miniature C. elegans laboratory, CeLab, that consists of microfluidic chips, automated fluid workflow, and image capturing and analysis platform to automate a variety of worm assays. CeLab chip is a highly complicated, reusable multi-layer Polydimethylsiloxane (PDMS) structure which has 200 separate incubation arenas allowing the long-term culture of 200 individual animals per chip (1000 ...

Tryglysin A and B Novel, Selective, and Potent Antibacterial Agents Against Streptococcus Bacteria

jdrayton@princeton.edu — Wed, 14 Jul 2021 06:15:43 GMT

Tryglysin A and B, Novel, Selective, and Potent Antibacterial Agents Against Streptococcus Bacteria Princeton Docket # 21-3758 Researchers in the Department of Chemistry at Princeton University and the Department of Pharmaceutical Sciences at the University of Illinois at Chicago have identified novel small organic molecules with potent and highly selective antibiotic activity. Tryglysin A and B are novel chemical structures with potent antibiotic activity against a narrow spectrum of bacteria. This narrow spectrum activity indicates the Tryglysins could be working through a novel an...

ReChat - An Integrated and Interactive Chat Suite for Online Survey Experiments

jdrayton@princeton.edu — Tue, 13 Jul 2021 08:18:25 GMT

ReChat - An Integrated and Interactive Chat Suite for Online Survey Experiments Princeton Docket # 21-3825 ReChat is an integrated and interactive chat suite that can be used by an individual researcher or research team to perform chat-based studies on any given topic. It allows researchers to administer, monitor, and analyze live conversations. ReChat allows researchers to recruit participants directly into live chat rooms that can be embedded in a Qualtrics survey, or used as a stand-alone interface. The intelligent ReChat suite lets researchers define instructions and questions to guide t...

Human IDO1- Selective Agonists for Treating Autoimmune Disorders

jdrayton@princeton.edu — Thu, 13 May 2021 09:40:08 GMT

IDO1 Selective Agonists for Treating Autoimmune Disorders Docket # 19-3557 The Groves lab in the Department of Chemistry at Princeton University has identified a new pathway in suppressing immune responses which may lead to novel compounds for treating autoimmune diseases. Proof of concept and a lead compound have been identified allowing for the development of novel derivatives through further drug discovery and medicinal chemistry efforts. Indoleamine 2,3-dioxygenase (IDO1) is a heme enzyme that catalyzes the oxygenation of the indole ring in tryptophan to affo...

A New Tool for Gene x Enviroment (GxE) Research - Variation Polygenic Score (vPGS)

jdrayton@princeton.edu — Mon, 10 May 2021 12:53:05 GMT

A New Tool for Gene x Environment (GxE) Research - Variation Polygenic Score (vPGS) Docket # 21-3797 Researchers in the Department of Sociology at Princeton University have developed an algorithm to calculate a particular type of genetic score, Variation Polygenic Score – vPGS, based on genotypic information that is provided by commercially available technologies ranging from “SNP-chips” to whole genome sequencing. Polygenic scores attempt to summarize the genetic propensity for, or risk, of a given phenotype, (i.e. disease or trait) an...

Trendme- Ratings in Real Time for Bettter Decisions for Consumer Goods and for Providers in Improved Services and Goods

jdrayton@princeton.edu — Mon, 19 Apr 2021 12:50:26 GMT

Trendme - Ratings in Real Time for Better Decisions for Consumers and for Providers in Improved Services and Goods Docket # 21-3769 Researchers in the Department of Sociology at Princeton University and in the Department of Psychology at Hunter College have developed a new process by which consumers and/or producers of goods and/or services can organize ratings temporally. The process can be achieved through a web browser extension on the user side or by the producer side as a feature of their display of ratings. This innovation allows the user to adjudicate betwee...

Plasma Systems for Air Decontamination

jdrayton@princeton.edu — Tue, 30 Mar 2021 18:32:12 GMT

Princeton Docket # 21-3764 Motivated by the current COVID-19 pandemic, Researchers at Princeton Plasma Physics Laboratory, Princeton University, have designed a novel plasma-based in-situ device for decontaminating air flow from viruses and bacteria in real time. The use of cold, low temperature plasma to eradicate pathogens is a tested and effective technology. The Princeton device is a new steady state approach to continuously decontaminate air in ventilation systems with heating and/or air conditioning without inducing thermal or other damage. This technology uses atmospheric plasma disch...

Self-Disinfecting Reverse Adhesive Bandages

jdrayton@princeton.edu — Mon, 01 Feb 2021 06:34:53 GMT

SELF-DISINFECTING REVERSE ADHESIVE BANDAGESPrinceton Docket # 21-3726 Researchers in the Department of Physics at Princeton University have designed a self-disinfecting reverse adhesive bandages for healthcare use. One of the primary mechanisms of viral and bacterial transmission, particularly SARS-CoV-2, is by transfer of the infectious agent by touch contact with a contaminated surface, and then touching another surface or person. Wearing of medical gloves, while that may prevent secondary transfer of the agent to the wearer, does not prevent surface to surface transfer. ...

Blink Lab – A Simple, Low Cost, Non-Invasive Tool for Use in Neurological and Psychiatric Disorders

jdrayton@princeton.edu — Fri, 29 Jan 2021 07:32:28 GMT

Blink Lab – A Simple, Low Cost, Non-Invasive Tool For Use in Neurological and Psychiatric Disorders Docket # 21-3740 Researchers in the Neuroscience Department at Princeton University have created a smartphone-based application that enables performing neurobehavioral tests, including but not limited to eyeblink conditioning. Eyeblink conditioning is a form of Pavlovian conditioning and is widely used in neuroscience to study mechanisms underlying learning and memory formation. Currently, eyeblink conditioning in humans requires expensive and dedicated hardware and software i...

Macrocyclic Peptides: Novel Antibiotic Treatment against Staphylococcus Aureus

jdrayton@princeton.edu — Thu, 10 Dec 2020 08:37:01 GMT

Macrocyclic Peptides : Novel antibiotic treatment against Staphyloccocus aureus Princeton Docket # 20-3668 Researchers at Princeton University and University of Tokyo have combined mRNA display technology with lipid-nanodisc based selections to identify high affinity ligands of the integral membrane sensor domain of the histidine kinase, AgrC. In S. aureus, virulence gene expression is under the control of the accessory gene regulator (agr) quorum sensing system. Within the agr circuit, AgrC, senses the quorum signal and is critical to the regulation of virulence. QQs are molec...

Novel Method to Monitor the Viral Proteome Throughout Infection for Use in Anti-Viral Drug Discovery and Vaccine Development

jdrayton@princeton.edu — Tue, 10 Nov 2020 07:49:55 GMT

Novel Method to Monitor the Viral Proteome Throughout Infection for Use in Anti-Viral Drug Discovery and Vaccine Development Princeton Docket # 20-3633 Researchers in the department of molecular biology at Princeton University have developed novel assays that use a targeted mass spectrometry approach to monitor viral proteins from all distinct temporal classes of a virus replication cycle within host cells. The replication of a herpesvirus in an infected cell and the spread of infection to neighboring cells relies on a finely controlled lifecycle with a temporally tuned cascade of viral...

Novel Small Molecule Agent for the Dispersal of Pseudomonas Aeruginosa, and other Type IV Pili Bacteria

jdrayton@princeton.edu — Wed, 04 Nov 2020 08:45:05 GMT

Novel Small Molecule Agent for the Dispersal of Pseudomonas Aeruginosa, and other Type IV Pili Bacteria Princeton docket # 20-3677 Researchers in the department of molecular biology, Princeton University, have identified a novel small molecule agent for the dispersal of P. Aeruginosa. Using an assay, called Dispersal of Initially Surface-attached Pathogens after Extract Lavage (DISPEL), they were able to isolate this molecule and using LC/MS and NMR they elucidated the structure and assessed the functionality of the molecule in being able to reduce bacterial gr...

Plasma Based in-situ Method to Sanitize in Real Time Door Knobs, Handles, Medical Equipment, Push Buttons, and Other Surfaces

jdrayton@princeton.edu — Fri, 28 Aug 2020 09:02:39 GMT

Plasma Based in-situ Method to Disinfect Surfaces in Real Time Princeton Docket # 20-3698 Motivated by the current COVID-19 pandemic, Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a novel plasma-based in-situ method for disinfecting surfaces in real time. The use of plasma to eradicate pathogens is a tested and effective technology in applications such as wound healing. The Princeton device is a new steady state approach to continuously disinfect surfaces that are often touched such as doorknobs, ATM keypads, elevator buttons, escalator...

Chemically Enhanced Plasma Sterilizer (CEPS)

jdrayton@princeton.edu — Thu, 27 Aug 2020 07:17:42 GMT

Chemically Enhanced Plasma SterilizerPrinceton Docket # 20-3703 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a chemically enhanced plasma sterilizer (CEPS) which uses atmospheric pressure cold plasma enhanced with a chemical reagent and UV light to provide sterilization and disinfection of bio-contaminated surfaces such as skin of human hands (with minimized UV), face masks, gloves, medical bandages, thin non-conductive and weakly conductive materials (e.g. paper, rubber, fabric, leather). Compared to the existing plasma-based sterilization device...

Low-Temperature Plasma Device for Sterilization and Anti-Viral Applications

jdrayton@princeton.edu — Thu, 27 Aug 2020 07:10:25 GMT

Low Temperature Plasma Device for Sterilization and Antiviral ApplicationsPrinceton Docket # 20-3699 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a flexible dielectric-barrier discharge (DBD) device which produces a uniform, cold plasma for disinfection and sterilization. The device can easily be made into desirable geometries for a multitude of applications. Cold plasma from DBD devices has been previously shown to have beneficial biological effects and promote significant killing of bacteria and virus inactivation without inducing thermal or oth...

Self-Disinfecting Plasma Fabric

jdrayton@princeton.edu — Wed, 26 Aug 2020 11:34:40 GMT

Self-Disinfecting Plasma FabricPrinceton Docket # 20-3706 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a self-disinfecting plasma fabric (SPDF) comprised of a specially woven electrical discharge source where plasma is ignited within the textile. The plasma sterilizes the fabric from within and can also be used to sterilize surfaces in contact with the fabric. SDPF is a textile and can be used to make garments, Personal Protective Equipment, wound dressings, covers, pads, masks, upholstery and much more. The disinfecting action is due to the bioac...

Solar Water Purification and Decontamination Hybrid Hydrogel

jdrayton@princeton.edu — Wed, 26 Aug 2020 10:01:17 GMT

Solar Water Purification and Decontamination Hybrid Hydrogel Princeton Docket # 20-3697-1 The laboratory of Prof. Rodney Priestley at Princeton University has developed a novel 3D solar absorber gel that can take full utilization of renewable solar energy for high-efficiency water purification and production. This is the first reported material that integrates all the desirable optical, thermal, and wetting properties to solve the long-standing clean water shortage crisis. The promising sunlight driven gel can significantly improve clean water production efficiency, inspiring n...

An Early Genetic Screening Aid in the Selection of Dogs for Assistance Training Programs

jdrayton@princeton.edu — Tue, 30 Jun 2020 08:50:58 GMT

An Early Genetic Screening Aid in the Selection of Dogs for Assistance Training Programs Docket # 20-- 3609 Researchers at Princeton University and Oregon State University have conducted a genome-wide SNP study and identified genomic regions under positive selection during the initial phase of dog domestication. Deletion of one of these regions in humans is linked to Williams-Beuren syndrome (WBS), a multi-system congenital disorder characterized by hyper-social behavior. This study provides evidence that structural variants (SVs) of three genes previously implicated in human WBS a...

Antibiotic Use of Ubonodin and its Derivatives Against Burkholderia Infections

jdrayton@princeton.edu — Tue, 19 May 2020 09:30:11 GMT

Antibiotic Use of Ubonodin and its Derivatives Against Burkholderia Infections Docket# 20-3606 Researchers at Princeton University have developed a novel compound that potently kills members of the Burkholderia genus, a notorious family of bacteria that includes multiple human and plant pathogens. Many Burkholderia are resistant to conventional antibiotics, so this compound represents a new strategy for applications in healthcare and biocontrol. The compound is robust, and exhibits thermal stability and shelf stability in both dissolved and dry forms. Applications: •&...

Reusable Self-disinfecting Gloves for the Mitigation of Pathogen Spread

jdrayton@princeton.edu — Tue, 12 May 2020 13:53:26 GMT

Reusable Self-disinfecting Gloves for the Mitigation of Pathogen SpreadPrinceton Docket # 20-3700 Researchers in the Department of Physics at Princeton University have designed reusable self-disinfecting gloves for both commercial and medical use. This technology functions by using an inner impermeable layer of material and an outer semipermeable membrane with a thin layer of disinfectant nested in between. The SARS-Cov2 pandemic has forcibly focused attention on the challenge of maintaining consistent daily vigilance with respect to contact media...

CO2-driven Diffusiophoresis of Colloidal Particles and Bacterial Cells

jdrayton@princeton.edu — Thu, 07 May 2020 20:19:01 GMT

Surface contamination due to the accumulation of particles and biofilm formation causes fouling of surfaces and malfunction of devices that process particulate materials (e.g. water purifying systems and medical devices). Researchers at Princeton have invented a novel process and a method for improving existing processes for the separation of particles and water/surface cleaning, including showing a significant effect on bacteria near surfaces. The proposed method describes a new way to manipulate bacterial cells so to delay or reduce their accumulation to a surface. Bacterial cells have a ne...

Taylorflavins and Cebulantin, Cryptic Antibiotics with Selective Antimicrobial Activity Against Gram-Negative Bacterial Pathogens

jdrayton@princeton.edu — Wed, 22 Apr 2020 06:06:33 GMT

Unlocking Therapeutic Cryptic Metabolites with Bioactivity-HiTES Princeton Docket # 20-3645 Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of “cryptic” biosynthetic gene clusters. These clusters can be easily identified bioinformatically, but are at best sparingly expressed under normal laboratory growth conditions; their products are therefore not interrogated during bioactivity-guided screening exercises. An estimated 80-90% of biosynthetic loci are cryptic, meaning that routine bioactivity screens will miss...

Voltage-Gating Device (VGD) for Cryogenic Electron Microscopy (Cryo-EM)

jdrayton@princeton.edu — Fri, 17 Apr 2020 12:03:33 GMT

Princeton Docket# 19-3561-1 Electric fields are widely used to switch nanoelectronics devices and can be precisely controlled by a variety of power sources. There are extensive studies of how electric gating affects materials’ physical properties, but it is still unclear, in most cases, how electric fields/currents change the structures or conformations of field-sensitive soft materials, liquid-solid interfaces, and biological molecules. Researchers at Princeton University have designed a novel device that can provide external stimuli, such as electric signals...

Data-Driven, Photorealistic Social Face-Trait Encoding, Prediction, and Manipulation Using Deep Neural Networks

jdrayton@princeton.edu — Tue, 31 Mar 2020 05:18:05 GMT

Data-Driven, Photorealistic Social Face-Trait Encoding, Prediction, and Manipulation Using Deep Neural Networks Princeton Docket # 19-3597 When one looks at a face, one cannot help but ‘read’ it: in the blink of an eye, people form reliable impressions of both transient psychological states (e.g., happiness) and stable character traits (e.g., trustworthiness). Such impressions are irresistible, formed with high level of consensus, and important for social decisions. Researchers at Princeton University and Stevens Institute of Technology have together developed a larg...

Sequential Multi-Step Flash Nanoprecipitation for the Formation of Small Nanoparticles with High Core Loading

jdrayton@princeton.edu — Tue, 10 Mar 2020 07:13:55 GMT

Flash NanoPrecipitation for Preparing High Capacity Nanoparticles Princeton Docket # 20-3636 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a new Flash NanoPrecipitation process, to form nanoparticles with high loadings. The new process, synthesizes nanoparticles with core loadings as high as 95%, with high homogeneity and minimal stabilizer trapping. These high capacity nanoparticles still retain durability for long term storage. Previously, Flash NanoPrecipitation all...

An Automated System to Measure Animal Body Part Dynamics

jdrayton@princeton.edu — Tue, 03 Mar 2020 08:04:38 GMT

SLEAP (Social LEAP Estimates Animal Poses): An Automated System to Measure Multi-Animal Body Part Dynamics Princeton Docket # 19-3510 Analysis of lab animal movements is a key element in a variety of behavioral studies. The current standard for analyzing animal movement relies on manual video annotation, which is time consuming, mentally taxing, and error prone. Faced with these challenges, researchers at Princeton University have developed an AI-driven multi-animal pose estimation software called SLEAP (Social LEAP Estimates Animal Pos...

A New Strategy to Seal Underground Fractures for Geologic Storage of Carbon Dioxide, and Treat Acid Mine Drainage Simultaneously

jdrayton@princeton.edu — Mon, 02 Mar 2020 07:58:46 GMT

Researchers in the Department of Civil & Environmental Engineering at Princeton University have invented a novel process to seal underground fractures for geologic storage of carbon dioxide, and treat acid mine drainage simultaneously. Fractures play an important role in a wide range of subsurface processes, including but not limited to geothermal energy production, subsurface remediation, oil and gas production, energy storage, and CO2 storage. For instance, in the case of geologic sequestration of CO2, fractures can serve as conductive pathways for CO2 to leak out of the storage location...

Metabolite Stimulation to Potentiate Nitrofuran Activity in Tolerant Bacteria

jdrayton@princeton.edu — Tue, 25 Feb 2020 09:25:22 GMT

Metabolite Stimulation to Potentiate Antimicrobial Nitrofurantoin Activity in Tolerant Bacteria Princeton Docket # 20-3641-1 Researchers in the Department of Chemical and Biological Engineering at Princeton University have discovered metabolites that stimulate the susceptibility of antibiotic tolerant bacteria to the antimicrobial agent nitrofurantoin. This technology functions by stimulating metabolic activity that is required to activate nitrofurantoin inside of tolerant bacterial cells. Antibi...

Novel High-Throughput Screening Method for Parkinson's Phenotypes Using C. elegans

jdrayton@princeton.edu — Tue, 25 Feb 2020 08:43:41 GMT

Novel High-Throughput Screening Method for Parkinson’s Phenotypes Using Caenorhabditis elegans Princeton Docket # 20-3640-1 Researchers at the Lewis-Sigler Institute for Integrative Genomics at Princeton University have developed an automated method to quantify Parkinson’s-like curling behavior in the nematode C. elegans. This method is used in conjunction with drug screening assays to expand experimental throughput by 30-fold to test compounds that may be useful in treating Parkinson’s disease (PD). ...

A Rating Method for Improved Accuracy of Customer Evaluations and Cost Savings

jdrayton@princeton.edu — Tue, 25 Feb 2020 07:18:06 GMT

A rating method for improved accuracy of customer evaluations and cost savings Princeton Docket # 20-3660 With the rise of analytics, good data is essential in today’s environment. Researchers in the Department of Sociology at Princeton University and in the Department of Psychology at Hunter College have developed a virtual rating method that associate online ratings with differential time costs by endowing the graphical user interface that solicit ratings from users with interactive “physics,” including an intuitive slidi...

Antibacterial Adjuvants for Pseudomonas Aeruginosa

jdrayton@princeton.edu — Tue, 18 Feb 2020 09:18:30 GMT

Antibacterial Adjuvants for Reduced Cationic Antimicrobial Peptide Dosing and Combination Therapy Princeton Docket # 20-3616-1 Researchers in the Department of Chemistry at Princeton University and the Department of Chemistry at San Jose State University have discovered compounds which increase the susceptibility of both CAP-resistant as well as non-resistant strains of P. aeruginosa to CAP antibiotic treatments. This technology functions by interfering with virulence factors that support both biofilm formation and the disruption of a host immune re...

A Bioelectric Device to Program Cell Migration in Multiple Dimensions

jdrayton@princeton.edu — Fri, 20 Dec 2019 07:08:20 GMT

Cell migration is extremely important in development, healing and regeneration, and disease progression. However, to date there are no commercial tools that allow such migration to be fully controlled in real-time and literally programmed by a user. Some existing technologies, including the “chemotaxis” process which uses chemical cues to direct cells are limited by the specific cell types and also lack the ability to precisely program the cells’ motion. A team of researchers in the Department of Mechanical and Aerospace Engineering at Princeton University has invented a...

Fluorescent in situ Hybridization of Transcript-Annealing Molecular Beacons (FISH-TAMB)

jdrayton@princeton.edu — Wed, 30 Oct 2019 07:42:53 GMT

Advancements in cellular imaging and high throughput sequencing have significantly increased our knowledge of microbial phylogenetic and metabolic diversity. However, it remains difficult to characterize cellular activities of most microbial species, especially low-abundance, slow-growing microorganisms. One such way to identify the taxonomy of single cells from environmental samples is through fluorescence in situ hybridization (FISH), which involves the use of fluorescent oligonucleotide linear probes targeting the universally conserved 16S ribosomal RNA (rRNA) gene. However, 16S rRNA-based ...

Data Assimilation Combining Hyper-resolution Land Surface Modeling and Radiative Transfer Modeling to Estimate Hydrological Processes at 30-m Spatial Resolution

jdrayton@princeton.edu — Fri, 20 Sep 2019 10:44:09 GMT

Accurate and detailed hydrological monitoring is essential for water resources management and field-scale decision making. Current satellite missions continue to improve the availability of information on hydrological processes, such as soil moisture, surface temperature, etc. However, their utility is limited by the large footprint of the sensors, which limits the direct application of these satellite data for field scale decision making. Researchers at Princeton University have invented a merging framework that uses hyper-resolution land surface modeling to efficiently assimilate and do...

Enhancing Immiscible Fluid Mobilization in Porous Media Using Solute Deposition induced Permeability Control

jdrayton@princeton.edu — Mon, 16 Sep 2019 07:53:15 GMT

Secondary imbibition is the process by which a wetting fluid displaces a non-wetting fluid in a partially saturated porous medium. Researchers at Princeton University have developed a novel process for mobilizing an immiscible fluid in a porous medium. An increase in the viscous pressure drop across trapped immiscible fluids in a porous medium can be achieved by locally reducing the permeability of the porous medium in the region immediately transverse to the ganglia with respect to the flow direction. This is accomplished by depositing colloidal particles to decrease the porosity and pore thr...

DiabDeep: Pervasive Diabetes Diagnosis Based on Wearable Medical Sensors and Efficient Neural Networks

jdrayton@princeton.edu — Tue, 10 Sep 2019 08:01:48 GMT

DiabDeep: Pervasive Diabetes Diagnosis based on Wearable Medical Sensors and Efficient Neural Networks Docket# 19-3591-1 Diabetes impacts the living quality of millions of people around the globe. Daily diabetes diagnosis and monitoring remain arduous but urgent given that the disease develops and gets treated outside of clinics. The emergence of Wearable Medical Sensors (WMSs) and machine learning points towards a potential way to address this challenge. Researchers at Princeton University propose a novel framework called DiabDeep that combines efficient neural networks (i.e.,...

A Genetically Humanized Mouse for Preclinical Testing of Specific Reagents Targeting Human CD81 and/or Human Occludin and for the Study of B Cell Lymphoma and Hepatitis C

jdrayton@princeton.edu — Wed, 04 Sep 2019 10:03:43 GMT

A Genetically Humanized Mouse for Preclinical Testing of Specific Reagents Targeting Human CD81 and/or Occludin for study of B cell Lymphoma and Hepatitis C Docket# 19-3577-1 The tetraspanin CD81, which is part of the B cell receptor complex, has emerged as an important immunotherapeutic target for treating B cell lymphoma. Researchers at Princeton University have constructed a knock-in mouse in which the second extracellular loop of CD81 was replaced with the respective human sequence. In this mouse model, humanized CD81 is expressed at physiological levels. Mice bearing the humani...

Physics-based Machine-learning Approach for Tropical Cyclone Risk Analysis

jdrayton@princeton.edu — Thu, 29 Aug 2019 08:32:01 GMT

Generating synthetic tropical cyclones is a general approach for assessing tropical cyclone hazards and risk applied by the government, wind engineering consultant labs, catastrophic modeling companies, and insurance companies. However, most methods currently in use can generate only storms under the observed climate conditions, as these models are simple statistical models that do not depend on physical parameters or climate variables. As climate change effects are getting more and more attention, there is an unmet need for a model that can generate tropical cyclones under future climate cond...

Controlling Immiscible Fluid Displacement in Porous Media Using Controlled Colloid or Solute Deposition

jdrayton@princeton.edu — Tue, 27 Aug 2019 08:36:18 GMT

Drainage is the process by which a non-wetting fluid displaces a wetting fluid from a porous medium. This phenomenon is ubiquitous, and arises in diverse settings including groundwater contamination, oil migration, gas venting from sediments, CO2 sequestration, mercury porosimetry, soil drying, liquid infusion into porous membranes, and oxygen accumulation within polymer electrolyte membranes. The ability to control the displacement pathway of the non-wetting fluid is critically important in all of these cases, but none of the current technologies in use can do so.Researchers at Princeton Univ...

Viscous Withdrawal for Micro-jet and Micro-drop Production

jdrayton@princeton.edu — Mon, 26 Aug 2019 08:42:46 GMT

The study of microscale drop or jet generation has catalyzed the invention of numerous biomedical and industrial technologies. Existing shear-based technologies require active control of both the continuous and the dispersed phases, therefore limiting their capacity for large scale parallelization. Researchers at Princeton University have invented a scalable method for controllable and high-throughput production of monodispersed micro-drops or uniform micro-jet (coefficient of variation of drop or jet diameter (CV) <5%). This selective viscous withdrawal system is comprised of a nozzle...

Guanfacine as an Anti-Virulence Agent in Pseudomonas Aeruginosa

jdrayton@princeton.edu — Mon, 15 Jul 2019 11:57:27 GMT

Guanfacine as an Anti-Virulence Agent in Pseudomonas aeruginosa Docket# 19-3565-1 Current anti-infective therapies against bacterial pathogens fall in two broad categories: vaccines and antibiotics. While vaccines serve in disease prevention, antibiotics kill pathogens after infection. However, since antibiosis creates a selective pressure for resistant bacteria, development of anti-infectives with anti-virulence properties has become imperative. Anti-virulence agents disarm bacterial virulence, thus preventing the onset of disease. Importantly, anti-virulence agents do not ...

Keratinimicins and Keratinicyclins- Novel families of antibacterial and antiviral agents

jdrayton@princeton.edu — Mon, 15 Jul 2019 11:14:57 GMT

Keratinimicins and Keratinicyclins- Novel families of antibacterial and antiviral agents Docket# 18-3381-1 Researchers at Princeton University have developed a rapid genetics-free method for eliciting and detecting cryptic metabolites. Utilizing this approach, the inventors have activated production of diverse cryptic metabolites and characterized several novel families, including the keratinimicins and keratinicyclins. Keratinimicins A & B are highly bioactive against several pathogenic bacteria, while keratinicyclins B & C have antiviral properties and show 20-fo...

Recombinant Phages for Targeted Bacterial Killing, Infection, Biodetection, and as a Means of Protein Extraction

jdrayton@princeton.edu — Wed, 12 Jun 2019 14:37:42 GMT

Recombinant Phages for Targeted Bacterial Killing, Infection, Biodetection, and as a Means of Protein Extraction Princeton Docket # 19-3527 Researchers in Princeton University’s Department of Molecular Biology have developed a recombinant phage platform technology that can be easily and precisely engineered for particular disease applications. Current phage therapies are restricted by issues of narrow target range and containment safety concerns. The elegant genetic components of this new system overcome these challenges. These recombinant phages infect and ki...

X-Ray Assisted Electron Microscopy Staining Procedure

jdrayton@princeton.edu — Wed, 29 May 2019 12:25:54 GMT

X-Ray Assisted Electron Microscopy Staining ProcedurePrinceton Docket # 19-3530 Researchers in the Princeton Neuroscience Institute, Princeton University have developed an X-ray assisted staining procedure, which allows for tight control over the staining process and can serve as a very important and unique entry point for staining quality control while the protocol is conducted. This could not only be very useful for any basic research lab that uses electron microscopy for example to study the ultra-structure of brain tissue, but more importantly, it could finally enable an industr...

Method to Characterize Bacteria in Three-Dimensional Porous Media

jdrayton@princeton.edu — Tue, 21 May 2019 07:00:23 GMT

Princeton Docket #19-3572Researchers at Princeton University have developed a novel method to characterize bacteria motion, self-organization, structure, and biological behavior in three-dimensional (3D) porous media by injecting them into a jammed hydrogel matrix. The matrix is self-healing and supports the weight of the bacterial cells, enabling them to be injected to form any 3D structure and with any composition of bacteria. The matrix is also transparent, enabling the cellular positions, motions, and genetic processes to be visualized using fluorescence microscopy. Since the matrix is sel...

Adeno-associated viral vectors containing alphaherpesvirus promoter sequences

jdrayton@princeton.edu — Wed, 10 Apr 2019 06:34:39 GMT

Novel Viral Gene Therapy Vectors for Increased Genetic Payload and Long Term Chronic Expression of Therapeutic Transgene Princeton Docket # 19-3539 Researchers in Princeton University’s Neuroscience Institute and Department of Molecular Biology have developed adeno-associated viral vectors (AAV) containing promoter sequences that are small in size yet able to provide strong, long-lasting transcription of any gene of interest. The size of such promoter sequences is less than that of commonly used promoters, allowing for larger size transgenes to be packaged into the AAV...

A Large-Area RFID Reader Array Using Large-Area Electronics

jdrayton@princeton.edu — Mon, 25 Mar 2019 12:12:27 GMT

Docket# Princeton 18-3454-1 A broad range of technologies and applications are being considered for IoT. RFID holds great promise in this regard due to its potential scale of deployment. However, short wireless range in passive HF RFID and the need for battery powering in active UHF RFID pose major limitations. Researchers at Princeton University have invented a novel large-area RFID reader array technology using large-area electronics, employing zinc oxide (ZnO) thin-film transistors (TFTs). The device enables RFID readers to be fabricated scalably as large arrays on thin flexible ...

Utilization of Human Recombinant Tinagl1 Protein in Inhibiting Triple-negative Breast Cancer Progression and Metastasis

jdrayton@princeton.edu — Fri, 21 Dec 2018 10:29:01 GMT

Utilization of human recombinant Tinagl1 protein in inhibiting triple-negative-breast cancer progression and metastasis Princeton Docket # 19-3526 Researchers in Princeton University’s Department of Molecular Biology have developed the human recombinant protein Tubulointerstitial nephritis antigen like-1 (Tinagl1) as a promising treatment for triple-negative breast cancer (TNBC). Patients with TNBC have the worst prognosis of all major breast cancer subtypes. Most treatments of TNBC fail due to the redundancies of the molecularly interconnected EGFR and integrin/FAK signaling ...

Automatic Video Based Spatial Co-Registration of Head Mounted Probes in Motion

jdrayton@princeton.edu — Fri, 07 Dec 2018 11:49:35 GMT

Automatic Video Based Spatial Co-Registration of Head Mounted Probes in Motion Princeton Docket #19-3514 Brain activity monitoring by electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) is an important step in the diagnosis of epilepsy, sleep disorders, coma and more. The spatial co-registration of scalp channel positions is a major challenge to data acquisition by these methods. Researchers at Princeton University’s Departments of Psychology and Computer Science have developed a quick and accurate method of scanning subject head shape that over...

Economical and Scalable Production of Submicron Particles and Coatings at Room Temperature

jdrayton@princeton.edu — Tue, 06 Nov 2018 11:43:57 GMT

Economical and Scalable Production of Submicron Particles and Coatings at Room Temperature Princeton Docket # 17-3329 The laboratory of Prof. Howard Stone has developed a novel technology for economical and scalable synthesis and production of submicron/nano-scale and nanostructured particulate materials. The technology incorporates unique liquid atomization method to produce submicron-sized (~200 nm) droplets, which, for the same solution, are 10-100 times smaller than the droplets in modern commercial systems. The continuous processing of precursor solution is rapid (order of a sec...

Potential Therapeutic for Arthropod-borne Flaviviruses, such as Yellow Fever, Dengue and Zika Viruses

jdrayton@princeton.edu — Fri, 02 Nov 2018 12:31:38 GMT

Potential Therapeutic for Arthropod-borne Flaviviruses, such as Yellow Fever, Dengue and Zika Viruses Princeton Docket # 18-3474 Researchers in the Department of Molecular Biology have discovered a human host factor that is required for effective yellow fever virus (YFV) infection of human cells. This molecule is unlike anything, in both structure and function, to what is known to regulate the life cycle of arthropod-borne flaviviruses. The potential compound has no reported cellular function therefore reducing the risks to the host which have been problematic in other targets invest...

Continuous and Membrane-less Filtration of Colloidal Particulates

jdrayton@princeton.edu — Thu, 25 Oct 2018 06:20:05 GMT

Continuous and Membrane-less Filtration of Colloidal Particulates Princeton Dockets # 17-3285-1, 16-3249-1 A novel method and device for separating suspended colloidal particles from aqueous stream without the use of a physical filter that is energy efficient, chemically non-invasive, and continuous. This method offers the potential to transform the cost of providing drinking water, in both high- and particularly low-income countries. Further, the superior performance of the process compared to filtration - removal of all but 0.0005% of the target particles – gives it application in a ra...

Bioremediation of Halogenated Organics (PFAS), Aromatic Hydrocarbons, Radionuclides, and Ammonium

jdrayton@princeton.edu — Wed, 24 Oct 2018 07:52:21 GMT

Bioremediation of Halogenated Organics (PFAS), Aromatic Hydrocarbons, Radionuclides, and AmmoniumPrinceton Dockets # 15-3080/2918-1, 18-3400-1, 19-3515-1, 19-3517-1A novel anaerobic bioremediation system capable of:1) Energy efficient anaerobic ammonium removal, at lower temperature than Anammox2) Degrading wide range of organic pollutants, including halogenated organics, PFAS, PFOA, and aromatics to harmless intermediates. 3) Trace metal/radionuclide immobilization, inclu...

Green and Safe Electrolytes for Multivalent-Ion (Mg, Ca, etc.) Batteries

jdrayton@princeton.edu — Mon, 01 Oct 2018 07:15:58 GMT

Green and Safe Electrolytes for Multivalent-Ion (Mg, Ca, etc.) Batteries Princeton Docket # 15-3142/3143/16-3237 Prof. Craig Arnold’s laboratory has developed a green and halide free electrolyte system for multivalent-ion (Mg, Ca, and others) batteries capable of reversible metal electrodeposition that is superior to current chemistries that utilize Grignard reagents. The Arnold group employs green chemical routes that bypass the need for highly reactive and flammable reagents, has the potential to be halide free (halides can cause pitting and corrosion in stainless steel), uti...

Immune System Activators that induce Double-stranded RNA

jdrayton@princeton.edu — Fri, 28 Sep 2018 10:03:06 GMT

Immune System Activators that Induce Double-stranded RNA Princeton Docket # 18-3436 Immunotherapy is becoming an increasingly popular cancer treatment strategy that harnesses the power of the patient’s own immune system. Researchers at Princeton University have developed synthetic molecules that derepress retroviral elements in the human genome and cause rapid activation of RNA decay by the OAS/RNase L branch of the interferon response. Importantly, RNase L is a prostate cancer suppressor that is encoded by the hereditary prostate cancer 1 allele. In addition, the OAS/RNAse L p...

An Ultrasonic Plasma Microphone for Structural Health Monitoring

jdrayton@princeton.edu — Wed, 19 Sep 2018 13:14:38 GMT

Princeton Docket # 17-3317-1 Researchers at Princeton Plasma Physics Laboratory, Princeton University, have invented a plasma microphone. The device uses plasma, an electrically conducting gas created by applying a voltage between two electrodes, to transduce acoustic waves to electronic signals. As a sound wave propagates through plasma, the pressure perturbation changes the electrical resistivity, which causes a current fluctuation that can be extracted as an electronic signal. The plasma microphone has high sensitivity that is virtually independent of frequency, a distinct advantage ov...

Nanoparticulate Apatite-Coated-Calcite/Limestone Filter Materials for Removing Contaminants From Contaminated Water

jdrayton@princeton.edu — Fri, 07 Sep 2018 14:29:48 GMT

Docket# 14-3027-1 Fluorosis, a disease caused by chronic excessive ingestion of fluoride (F-) primarily through drinking contaminated groundwater, is a major health challenge particularly in developing countries. Excess fluoride may produce several health problems such as dental fluorosis, skeletal fluorosis and various neurological manifestations. Several remediation strategies currently exist, but they suffer from high operation and maintenance costs and/or production of secondary pollutants. Researchers at Princeton University have invented a novel apatite-based sorbent for defluoridat...

Injectable Hydrogels From Microfiber Suspensions

jdrayton@princeton.edu — Tue, 21 Aug 2018 09:40:03 GMT

Princeton Docket # 15-3163-1 Researchers at Princeton University, Department of Mechanical and Aerospace Engineering, have developed a new hydrogel material. This invention describes a new type of hydrogel material composed of flexible hydrophilic microfibers. A concentrated suspension of the microfibers undergoes irreversible gelation using a simple mechanical process. The fiber hydrogel exhibits typical properties of a gel: the mechanical properties are consistent with that of a soft viscoelastic solid and it swells in water. The hydrogel forms in situ, so it can be used as an inje...

Inhibiting Bacteria Infection in Healthcare Devices through Surface Chemistry Treatments and Fluid Flow Control

jdrayton@princeton.edu — Tue, 21 Aug 2018 09:39:51 GMT

Princeton Docket # 15-3109-1 Researchers in the Departments of Molecular Biology and Mechanical and Aerospace Engineering at Princeton University have designed new methods to effectively inhibit the entry, spread and growth of bacteria. The entry of pathogenic bacteria into fluid-filled networks of the body causes serious infection and sepsis. In particular, sepsis is one of the most expensive conditions to treat in hospitals, costing more than $20 billion in 2011. Also, Pseudomonas aeruginosa is a major cause of hospital-acquired infections, burn infections, and cystic fibrosis inf...

Microfluidic Method for Continuous Production of Microfibers With Embedded Droplets

jdrayton@princeton.edu — Tue, 21 Aug 2018 09:39:35 GMT

Microfluidic Method for Continuous Production of Microfibers with Embedded Droplets Princeton Docket #14-2982 Fibers are a useful medium for numerous applications, including drug delivery. Current technologies usually make fibers of homogeneous chemical composition or employ axial core-shell structures. To create more complex shapes and compositions, external machinery such as programmable valves have been incorporated to produce multi-compartment fibers (Kang et al., Nature Materials, 2011, 10, 877). In order to develop even greater functionality, researchers in the Department of Mechan...

Droplet Adhesion for Breaking Oil-In-Water Emulsion and Phase Separation

jdrayton@princeton.edu — Tue, 21 Aug 2018 09:39:12 GMT

Droplet Adhesion for Breaking an Oil-in-Water Emulsion and Phase Separation Princeton Docket # 14-2952 Present microfluidic technologies to break emulsions or to separate phases in the emulsions include electric-field enhanced coalescence, passive-controlled coalescence, and a phase separator with embedded porous membrane. Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have developed a novel, simple and reliable method to break stable oil-in-water emulsions. The invention describes a device to break stable oil-in-water emulsio...

A Device for Mechanically Detecting Anomalous Battery Operation

jdrayton@princeton.edu — Tue, 21 Aug 2018 09:38:32 GMT

Princeton Docket # 15-3151-1 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have developed a new device which monitors mechanical changes in a battery cell and predicts a battery failure event before it happens. Battery failures are commonly thought of as being unpredictable, arising from unexpected sources such as internal defects, adverse environmental conditions, and faulty controllers. Conventional battery management systems can identify the occurrence of failure events by detecting anomalous battery cell behavior using non-mechanica...

Lithium Coating to Remove Impurities in Vacuum Systems

jdrayton@princeton.edu — Thu, 19 Jul 2018 07:43:08 GMT

Princeton Docket # 18-3401 Removing water and impurities from the walls of the chamber of is an important consideration in sensitive high vacuum systems. Researchers at the Princeton Plasma Physics Lab have invented a new process to quickly release lithium vapor into these systems, using a porous stainless steel tube containing liquid lithium and a heating element. Designed to control impurities in fusion reactors, this invention also has immediate application in chemical and physical vapor deposition industries. Traditionally, these industries use getter materials such as titanium ...

DYNAFLOW

jdrayton@princeton.edu — Mon, 09 Jul 2018 12:47:43 GMT

BRIEF HISTORY OF DYNAFLOW AND ITS UNIQUE CAPABILITIES Dynaflow has been developed over the past 40 years by Professor Jean H. Prévost while at Princeton University. The code has evolved greatly since its beginnings and has undergone several significant changes in data structure and solution strategies to accommodate an ever evolving computing and hardware environment. It is written in Fortran 77/90 and currently has over 850,000 source lines. Dynaflow has been developed in an academic research environment which encourages innovation in approaches and novel solution procedures. It ...

Plasma-Based Laser Pulse System: Higher Power, Sharper Wavefront

jdrayton@princeton.edu — Fri, 15 Jun 2018 08:24:45 GMT

Princeton Docket # 17-3296, 17-3311, 17-3333 Current laser systems are inherently brilliance-limited by the ability of the internals to resist damage by the laser. To overcome this thermal threshold, researchers at the Princeton Plasma Physics Laboratory have invented techniques to improve the current laser amplifiers based on Raman instability in plasmas. A process was invented to use magnetized plasmas as the gain media combine counter-propagating laser beams. Using magnetized plasma to mediate energy transfer makes it possible to use pump lasers of higher frequency or lower inten...

A High Throughput Assay for the Repurposing and Development of Drug Compounds as Novel Antibiotics

jdrayton@princeton.edu — Fri, 01 Jun 2018 05:52:11 GMT

A High Throughput Assay for theRepurposing and Development of Drug Compounds as Novel Antibiotics Princeton Docket # 15-3074 The Gitai Laboratory at Princeton University has developed a high throughput assay to screen existing small molecule compound libraries to identify antibiotic activity with novel mechanisms of action. This assay can facilitate the rapid and inexpensive development of the novel use, or repurposing, of these compounds and their derivatives as new antibiotic drugs. Gitai Lab’s high throughput assay was developed to accommodate practical situations wher...

Rapid and High Yield Reduction of CO2 to Commercially Valuable Multi Carbon Products

jdrayton@princeton.edu — Thu, 31 May 2018 12:07:05 GMT

Rapid and High Yield Reduction of CO2 to Commercially Valuable Multi Carbon Products Princeton Docket # 18-3372-1 The laboratory of Prof. Andrew Bocarsly has created a collection of alloy electrodes capable of reducing CO2 to high value multi-carbon products in a fast, efficient, and high yield manner that is industrially attractive for CO2 utilization. The electrochemical transformation of CO2 to chemical feedstock and energy sources is of importance for a sustainable future. While there is a limited number of potentially pragmatic routes to reduce CO2 to single...

Efficient Encapsulation of Hydrophilic Biologics into Nanocarriers

jdrayton@princeton.edu — Fri, 25 May 2018 09:35:04 GMT

Efficient Encapsulation of Hydrophilic Biologics into NanocarriersPrinceton Docket # 18-3414-1 The research team at Princeton University has demonstrated a novel and efficient method to encapsulate highly water-soluble biologic active pharmaceutical ingredients into nanocarriers using a single precipitation step. Nanoprecipitation of active pharmaceutical ingredients into drug carriers is an attractive method for producing formulations with improved nanoparticle stability and biological efficacies. However, nanoprecipitation techniques are generally applicable for only highly hydroph...

An Economical Design and Processing of Lipophilic Drugs for Fast-Releasing Water Dispersible Formulations

jdrayton@princeton.edu — Fri, 25 May 2018 09:27:38 GMT

An Economical Design and Processing of Lipophilic Drugs for Fast-Releasing Water Dispersible Formulations Princeton Docket # 18-3396-1 The Prud’homme group has developed a novel, economical, and scalable formulation and process to prepare nanoparticles from poorly water soluble drugs in order to improve oral bioavailability and dissolution rate of lipophilic drugs where convention methods (i.e., milling) are not adequate. As a proof of concept, the team has demonstrated that nanoparticles of the poorly water-soluble, Biopharmaceutics Classification System class II drug Cl...

Decreased Fabrication Cost of High Performance Super Conducting Magnets

jdrayton@princeton.edu — Mon, 14 May 2018 10:31:29 GMT

Decreasing the cost of manufacturing high performance super conducting magnets is important for many industries including NMR and MRI magnets. Researchers at the Princeton Plasma Physics Lab have invented a new method to simplify the Nb3Sn coil winding process to reduce organic insulation and liquid He3 cooling requirements. At the same time, this process increases winding pack density and structural integrity. Coils are first wound on a steel coil form using bare wire without the conventional glass sleeve insulation. After heat treatment, structural reinforcement is applied to the exter...

Slow Light Imaging Spectroscopy

jdrayton@princeton.edu — Fri, 27 Apr 2018 07:57:22 GMT

Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have invented a new spectroscopy technology that enables ultra-high resolution one and two dimensional spatial imaging of Rayleigh, Raman, and Thomson spectral features without the need for a spectrometer. The approach provides the capability for imaging of a single spectral feature such as a single rotational Raman line and the simultaneous elimination of background scattering. High collection efficiency provides the opportunity for single pulse time frozen images to be acquired. This inve...

A Device for Self-Myofascial Release of Lower Back Muscle Groups

jdrayton@princeton.edu — Fri, 16 Mar 2018 06:30:57 GMT

Muscular lower back injuries are prevalent in most athletes. These injuries are a result of over-contracted muscle groups that are subject to rapid strains, causing them to tear. Myofascial Release (MFR) is an effective, non-abrasive technique that involves the application of pressure on certain specific points of the painful muscle. It has proven to be an effective method to mitigate lower back pain by releasing the over-contracted muscles back to a neutral state. Current treatment options consist of costly massage techniques or devices such as foam rollers that do not support the spine and c...

Trackable Quorum-Sensing Molecules for Diagnostic Applications

jdrayton@princeton.edu — Mon, 22 Jan 2018 06:07:01 GMT

Princeton Docket # 17-3325-1 High quality medical imaging technology has been one of most important developments in clinical care and personalized medicine. Pinpointing the source and cause of disease in a patient allows targeted and optimal treatment, saving time and money. Applying this type of imaging accuracy to the identification of bacterial pathogens and infection sites is a critical unmet need. Overuse of broad-spectrum antibiotics is rapidly selecting for resistance, but the time required to biopsy and culture for species determination limits the use of targeted techniques. To al...

A Real-time Biosensor of Antiproliferative Immune Messenger 2-5A for Research, Diagnostics, and High-throughput Screening

jdrayton@princeton.edu — Fri, 01 Dec 2017 08:07:54 GMT

Princeton Docket # 17-3323-1 Princeton researchers have engineered a light emitting reporter to measure the real-time buildup of 2’-5’ linked oligoadenylates (2-5As) biochemically and in live cells using a one-step, high-throughput method.2-5As are produced in stressed human cells that accumulate double stranded RNA (dsRNA). 2-5A serves as specific activators of cellular RNA processing by kinase-ribonuclease RNase L, which rapidly stops cell-wide translation. 2-5A levels can serve as a marker of dsRNA presence, i.e. to assess viral infections and cell stresses associated with ...

DEEPs - De novo Expression Enhancer Proteins for Improved Protein Expression and Purification

jdrayton@princeton.edu — Wed, 15 Nov 2017 05:03:41 GMT

Princeton Docket # 17-3357-1 To improve the production of biomedically important peptides and proteins that are challenging to express with recombinant DNA technology, researchers at Princeton University have created a collection of synthetic genes to encode highly stable de novo proteins for use as genetic fusion tags. The resulting method has been shown to enhance expression level, improve solubility, decrease degradation, and favor folding of the proteins and peptides of interest. This new composition of genes are small (~100 amino acids) and therefore do not impose a significant ...

A Direct Route to Prepare Isocyanates via C-H Activation for Drug Discovery

jdrayton@princeton.edu — Mon, 13 Nov 2017 05:36:02 GMT

Princeton Docket # 18-3374-1 The first and only method for preparing high-valued aliphatic isocyanates via direct C-H activation has been developed by researchers at Princeton University. Organic isocyanates are versatile intermediates that provide access to a wide range of functionalities found in pharmaceuticals and agrochemicals. This method harnesses the synthetic utility of isocyanates and the ubiquitous C-H bonds in organic molecule to enable more step economical routes to compounds that are difficult to prepare. The reaction proceeds efficiently at room temperature and can be...

A Behavior-based AI Consciousness Test

jdrayton@princeton.edu — Mon, 25 Sep 2017 11:36:37 GMT

Princeton Docket # 18-3370 As artificial intelligence becomes more integrated into our lives, there is an increasing need to probe whether it can be conscious. If a given type of AI is conscious (i.e., if it feels like something to be an AI) ethical considerations can halt its marketability. Further, testing is key to determine how AI consciousness impacts AI intelligence, safety, empathy and goal content integrity. The Turing test does not probe whether an AI is conscious, it only judges whether the output can pass for that of human. It cannot determine whether the synthetic ...

Simple Genomic Test of Canine Genes Associated With Williams-Beuren Syndrome Could Predict Social Behavior in Domesticated Dogs

jdrayton@princeton.edu — Fri, 25 Aug 2017 08:46:45 GMT

Docket # 17-3362 Although considerable progress has been made in understanding the genetic basis of morphologic traits (e.g. body size, coat color) in dogs and wolves, the genetic basis of their behavioral divergence is poorly understood. Researchers at Princeton University have conducted a genome-wide SNP study and identified genomic regions under positive selection during the initial phase of dog domestication. Deletion of one of these regions in humans is linked to Williams-Beuren syndrome (WBS), a multi-system congenital disorder characterized by hyper-social behavior. This study prov...

Calibration Procedures for Rotating Lorentz-Force Flowmeters: Non-Contact Flow Measurement for Electrically Conductive Fluids

jdrayton@princeton.edu — Thu, 24 Aug 2017 09:08:09 GMT

Princeton Docket # 17-3301 Measuring the flowrate of extremely high-temperature or chemically aggressive fluids is a challenge faced by a variety of different industrial processes (e.g. metal casting, nuclear power, concentrated solar power, chemical production, etc.). Rotating Lorentz-force flowmeters (RLFFs) are non-contact devices that can operate within these systems by measuring subtle changes of the Lorentz-force produced by the flowing liquid. (The Lorentz-force is generated when the fluid flows across a magnetic field produced by the RLFF.). Traditionally, calibrating ...

New Quantitative Method to Apply Tagmentation Technology to ChIP-Seq

jdrayton@princeton.edu — Thu, 24 Aug 2017 09:05:19 GMT

Princeton Docket # 16-3268 Chromatin immunoprecipitation (ChIP) is an affinity assay for detecting the interaction between a particular protein and DNA in cells. Using a protein-specific antibody, DNA bound by that protein can be isolated and identified using high throughput sequencing (ChIP-seq). One desirable way to prepare a DNA library for sequencing is known as tagmentation, where a high-activity transposase is used to fragment and tag DNA with sequencing adapters. Researchers in the Lewis-Sigler Institute for Integrative Genomics at Princeton University have developed a greatly impr...

Method for Facilitating Pattern Recognition by Unsupervised Neural Networks

jdrayton@princeton.edu — Tue, 22 Aug 2017 09:27:47 GMT

Docket # 15-3161 Exponential increases in computing and imaging technology have both enabled and necessitated machine-based alternatives to human image analysis. To solve this challenge, computer scientists have created multi-layer artificial neural networks (ANNs), a field colloquially known as “deep learning”. The most successful of these networks are typically supervised, or trained on a large number of correctly labeled inputs. While such ANNs have achieved near-human performance, they require the laborious assembly of labeled training sets. To unlock the full potential of...

Inhibiting Quorum Sensing of Bacteria in Healthcare and Industrial Devices Through Conjugation of Anti-Quorum Sensing Molecules to Surfaces

jdrayton@princeton.edu — Mon, 07 Aug 2017 08:09:06 GMT

A surface-coating approach for bacteria-free health-care and industrial devices Docket # 15-3136 Bacteria frequently act as members of collectives to create surface-attached communities called biofilms and to synchronously activate the production of virulence factors. Bacterial group behaviors are regulated by a cell-cell communication process called quorum sensing (QS) which involves the production, release, and population-wide detection of extracellular signal molecules called autoinducers. Researchers at Princeton University have invented a process to manipulate QSmediated commu...

Tracking a Smartphone User Around the World

jdrayton@princeton.edu — Mon, 24 Jul 2017 12:25:06 GMT

Accurately Tracking a Smart Device Using Non-GPS Based Sensor DataPrinceton Docket # 16-3275 With the rapid proliferation of smart devices such as wearables, cell phones, and self-driving cars, high-accuracy location-tracking services have become increasingly important. Previous high-accuracy techniques have used GPS data, but this can carry significant downsides such as high battery usage, potential service blackout, and the risk of malicious GPS spoofing. Inventors at Princeton University in the Department of Electrical Engineering have developed a novel user-location algorithm na...

Single-Step Method to Fragment and Tag Both Ends of DNA Molecules with Arbitrary Nucleotide Sequences

jdrayton@princeton.edu — Fri, 09 Jun 2017 12:56:15 GMT

One-step method to fragment and tag both ends of DNA for Next Generation Sequencing (NGS)Princeton Docket # 17-3313 Researchers in the Lewis-Sigler Institute for Integrative Genomics at Princeton University have developed a new simplified method to fragment and tag both ends of DNA molecules with arbitrary nucleotide sequences for Next Generation Sequencing as well as other high-throughput DNA processing. This invention combines all reagents in a single step to fragment and tag both ends of DNA molecules with desired nucleotide sequences with optional PCR amplification, while a...

Optogenetic Tool for Rapid and Reversible Clustering of Proteins

jdrayton@princeton.edu — Mon, 05 Jun 2017 12:50:11 GMT

Light Activating Genetic Tools for Rapid and Reversible Clustering of Proteins In Vivo ` ...

A New Class of Focusing Crystal Surfaces for the Bragg Spectroscopy of High-Density Plasmas and Small (Point-Like) X-Ray Sources

jdrayton@princeton.edu — Mon, 01 May 2017 09:14:23 GMT

A new class of focusing crystal surfaces for the Bragg spectroscopy of high-density plasmas and small x-ray sources Princeton Docket # 15-3175-1 Researchers at Princeton Plasma Physics Laboratory, Princeton University have identified a new class of crystal surfaces that makes it possible to maximize the photon throughput of a Bragg crystal spectrometer for a specified spectral range. Currently, the x-ray Bragg spectroscopy of laser-produced high-density plasmas applies only standard crystal forms, such as flat crystals, spherically, cylindrically, or toroidally bent crystals and crystals ...

A Multi-Cone X-Ray Imaging Bragg Crystal Spectrometer

jdrayton@princeton.edu — Mon, 01 May 2017 08:49:01 GMT

A multi-cone x-ray imaging Bragg crystal spectrometer Princeton Docket # 16-3250-1 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a new multi-cone x-ray imaging Bragg crystal spectrometer for the spectroscopy of small (point-like) x-ray sources, which in contrast to Hall’s, currently used standard single-cone x-ray crystal spectrometer, can provide high spectral resolutions of E/ΔE=10,000 for each wavelength in a selectable spectral range.Another important advantage of this new multi-cone x-ray imaging Bragg crystal spectrometer is that ...

A Hierarchical Health Decision Support System Based on Wearable Medical Sensors and Machine Learning Ensembles

jdrayton@princeton.edu — Thu, 23 Mar 2017 12:17:53 GMT

A Hierarchical Health Decision Support System based on Wearable Medical Sensors and Machine Learning EnsemblesDocket # 17-3310Researchers at Princeton University in the Department of Electrical Engineering have developed a new hierarchical health decision support system (HDSS) that integrates health data from wearable medical sensors (WMSs) into clinical decision support systems (CDSSs) and can evaluate the health profile for anyone anywhere anytime.HDSS is the first system that combines WMSs and CDSSs in a carefully structured information framework. The system has a multi-tier structure, star...

Keep the Stress Away With SoDA: Stress Detection and Alleviation System

jdrayton@princeton.edu — Mon, 20 Mar 2017 09:32:38 GMT

Keep the Stress Away with SoDA: Stress Detection and Alleviation System for Continuous and User-transparent Stress Monitoring and Mitigation Docket # 17-3308 Researchers at Princeton University in the Department of Electrical Engineering have developed a new system to detect and alleviate stress in a continuous, adaptive, and user-transparent manner, i.e., without the need for user intervention.The system is an automatic stress detection and alleviation system called SoDA that provides immediate and precise stress detection with user-specific and a...

Standoff Detection and Imaging Using Point-and-Line-CARS

jdrayton@princeton.edu — Mon, 13 Feb 2017 07:37:57 GMT

Highly Sensitive Standoff Molecular Detection and Imaging Using CARS Princeton Docket # 13-2867-1 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University use a technique (CARS) to provide real-time detection of trace amount of solids at range. Real-time spectroscopy and detection of trace species is very challenging due to the difficulties to achieve both selectivity and sensitivity. Raman vibrational spectroscopy has been proven to give exceptional molecular identification, but the sensitivity is low. For standoff detection a very sen...

Low Radioactivity Argon Gas for Radiation Detectors

jdrayton@princeton.edu — Tue, 24 Jan 2017 12:52:04 GMT

Princeton Docket # 15-3088-1 & 15-3100-1 Radiation detectors and dark matter research utilizes non-radioactive isotopes of argon gas, since radioactivity impacts the effectiveness of such detectors. A quality assurance method is clearly needed for the industrial and research use of low radioactivity argon gas. However, measuring the argon radioactivity is a time-consuming process (weeks-months), since the half-life of radioactive ³⁹Ar is centuries long. Therefore, this method is not suitable for the large production of low radioactivity underground argon, and creates difficulties in...

Separation of Particles in Suspensions by Contact With Gas Phase

jdrayton@princeton.edu — Tue, 20 Dec 2016 07:17:05 GMT

Princeton Docket # 16-3249-1Researchers at Princeton in the Department of Mechanical and Aerospace Engineering have developed a method for concentrating suspended particles in suspensions that could be used to attract/repel particles to/from a surface. Methods for concentrating particles suspended in a liquid are useful for many industrial and scientific applications, especially when the particles are small and their concentration is low. Current methods use external forces such as gravity and electric fields for concentration and separation of particles in suspensions and are generally ...

Sensitive and Accurate PCR Detection of dsRNA Response: Novel Biomarkers for Autoimmune and Infectious Diseases

jdrayton@princeton.edu — Tue, 13 Dec 2016 07:51:36 GMT

Princeton Docket # 16-3253-1 Researchers in the Department of Molecular Biology, Princeton University have identified an innovative qPCR-based method for accurate and specific detection of immune marker RNAs generated by the action of double-stranded RNA (dsRNA) and RNase L. These markers provide one-of-a kind diagnostic tools for the dsRNA response and novel biomarkers for autoimmune, inflammatory and infectious diseases. RNase L is an immune kinase with an RNase domain, which cleaves intracellular RNAs in response to dsRNA. The presence of dsRNA is a mark of inflammation, DNA damage or...

Small Molecule Potentiation of Phage Antimicrobial Activity For Use in Medical, Industrial, Agricultural, and Food Safety Applications

jdrayton@princeton.edu — Mon, 12 Dec 2016 07:03:22 GMT

Princeton Docket # 16-3239-1 Researchers in the Department of Molecular Biology at Princeton University have developed an innovative therapy for the treatment of bacterial infections. The invention combines two unique discoveries to generate a novel, safe approach to combat bacterial infections without generating resistance. The first discovery is small molecule inhibitors of the key quorum sensing (“QS”) regulators in the pathogen P. aeruginosa. QS is required for P. aeruginosa virulence and biofilm formation. The second discovery is that CRISPR-Cas mediated bacterial immuni...

Knockout Sudoku: A unique method for creation of whole genome knockout collections

jdrayton@princeton.edu — Wed, 07 Dec 2016 12:38:24 GMT

Princeton Docket # 16-3258-1Researchers at Princeton in the Department of chemistry have invented a new method that significantly lowers the cost, time and complexity for construction of whole genome knockout collection. Whole genome knockout collections could accelerate gene and drug target discoveries by providing new insights into antibiotic resistance, pathogenic virulence and photosynthetic energy storage. Current methods for the creation of whole genome knockout collections are extremely expensive, complex and time consuming. Knockout Sudoku uses a simple manual procedure that drop...

A Solid-State Organic Intermediate Band Solar Cell Based on Principles of Triplet-Triplet Annihilation

jdrayton@princeton.edu — Tue, 22 Nov 2016 07:51:02 GMT

Princeton Docket # 16-3248 Researchers in the Department of Electrical Engineering at Princeton University have invented the first solid-state intermediate band organic solar cell device. This device architecture, made from commercially available materials, enables increased solar cell efficiency by converting low energy solar photons into electrical current and in turn results in higher solar cell efficiencies. Organic photovoltaics (OPVs) represent a promising class of emerging solar energy technologies. Because of the ability to print OPVs on a large scale using low temperature pr...

Method of Forming and Applications of Metal Halide Perovskite Films With Small Crystallite Size

jdrayton@princeton.edu — Tue, 22 Nov 2016 07:31:24 GMT

Princeton Docket # 16-3243 Researchers in the Department of Electrical Engineering at Princeton University have developed a method for controlling the microstructure of hybrid organic-inorganic perovskite films via a straightforward, low temperature, and scalable process. The fine control and tunability of film properties leads to improved efficiencies for devices such as light-emitting diodes (LEDs), photodetectors, solar cells, lasers, and large-area printable electronics. Recently, the demand for highly efficient and low cost solar cells and LEDs has resulted in a resurgence in re...

Overlap Optimization of Nonlinear Frequency Conversion in Multi-Mode Cavities

jdrayton@princeton.edu — Mon, 14 Nov 2016 08:03:18 GMT

Princeton Docket # 16-3222-1Researchers at Princeton in the Department of Electrical Engineering have invented a new computational technique for the design of a novel class of ultra-compact micro/nano-scale devices which can be used for high-efficiency nonlinear wavelength conversion in multi-mode cavities. High-efficiency coherent wavelength conversion is crucial to various areas of science and technology such as LEDs and lasers, spectroscopy, microscopy and quantum information processing. Current technologies employ wavelength converters with bulky nonlinear crystals (e.g. LiNbO3) to co...

Hardware/Software Architecture for Improving the Safety of Implantable and Wearable Medical Devices

jdrayton@princeton.edu — Tue, 08 Nov 2016 06:33:35 GMT

Hardware/Software Architecture for Improving the Safety of Implantable and Wearable Medical Devices Princeton Docket # 16-3226-1 Implantable and wearable medical devices (IWMDs) have become increasingly sophisticated over the years and are now commonly equipped with advanced features. However, unsafe operations of IWMDs such as software bugs, malicious attacks, or even user errors are of utmost concern to patients since they can be life-threatening. Inventors at Princeton University in the Department of Electrical Engineering and at Purdue University have developed a novel appr...

CABA: Continuous Authentication Based on BioAura

jdrayton@princeton.edu — Tue, 08 Nov 2016 05:07:50 GMT

Continuous Authentication for Cybersecurity Princeton Docket # 16-3233 Computing devices and servers need to be protected against unauthorized access, because such systems may store sensitive information, and the information can be used to access other restricted systems and resources. Most computer systems only authenticate users once at the time of initial login, which can lead to security concerns. Continuous authentication has been explored as an approach for alleviating such concerns. Previous methods for continuous authentication primarily use biometrics (e.g., fingerprin...

Electromagnetic Self-Erasing Chalkboard

jdrayton@princeton.edu — Fri, 28 Oct 2016 08:34:34 GMT

Princeton Docket # 16-3217-1Researchers at Princeton in the Department of Mechanical and Aerospace Engineering have designed a self-erasing chalkboard for improving the quality of classroom learning. Conventional chalkboards are erased via the physical motion of moving a chalk eraser over prior chalk marks. Using electromagnetism, this new chalkboard immediately self-erases, providing a clean slate for educators to continue teaching. This invention employs a unique chalk composition, which was designed using an advanced understanding of fracture mechanics, to dramatically improve the era...

Root ORAM: A Tunable Differentially Private Oblivious RAM

jdrayton@princeton.edu — Mon, 24 Oct 2016 06:55:18 GMT

Princeton Docket # 16-3221-1Researchers at Princeton in the Department of Electrical Engineering have designed a unique Oblivious RAM (Root ORAM) that provides an application- specific low bandwidth with rigorous privacy guarantees of a differentially private ORAMs with tunable privacy-utility trade-off to achieve private access of data. Use of current oblivious RAM (ORAM) in high-performance and bandwidth-constrained applications is challenging due to significant bandwidth overheads. This invention provides low overhead schemes to perform oblivious access. It takes into account the desig...

Disintegrated Channel Estimation in Filter-and-Forward Relay Networks

jdrayton@princeton.edu — Thu, 20 Oct 2016 09:11:21 GMT

Princeton Docket # 16-3215-1 Researchers in the Department of Electrical Engineering at Princeton University have developed a new process for channel estimation in modern wireless multi-relay cellular networks to enable increased signal quality and lower outage probability without the need for infrastructure upgrades or modifications. In general, modern cellular networks are composed of base stations that are connected to relays to enable greater coverage, better signal quality and/or higher throughput in a cost-effective fashion. These advantages come at the cost of increased netwo...

Initial Synchronization Exploiting Inherent Diversity for the LTE Sector Search Process

jdrayton@princeton.edu — Fri, 16 Sep 2016 09:07:53 GMT

Initial Synchronization System for the LTE Sector Search Process Princeton Docket # 16-3216-1Researchers at Princeton in the Department of Electrical Engineering have designed a novel initial synchronization system for the LTE sector search process to provide better coverage, lower outage probability, rapid initial synchronization and rapid handover. This invention, comprises three subsystems, takes inter-cell interference, inter-carrier interference and mu...

Self-Aligning Mirror Mechanism for Transmission Line Offset Correction

jdrayton@princeton.edu — Tue, 30 Aug 2016 13:34:55 GMT

Princeton Docket # 16-3187 Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a self-aligning mirror mechanism for transmission line offset correction. The self-aligning mechanism automatically adjusts mirrors to couple radiation between two or more offset waveguides or optical fibers. It is currently used to direct microwaves through two offset waveguides that are moving relative to each other. The uniqueness of this device is that it is self-aligning and functions to maintain critical geometric relationships necessary to allow for wave passage while a...

Metal@Polymer Nanoparticles by Simultaneous Precipitation and Reduction

jdrayton@princeton.edu — Tue, 23 Aug 2016 06:14:17 GMT

Metal@Polymer Nanoparticles by Simultaneous Precipitation and Reduction Princeton Docket #14-3014 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a simple one-step synergistic preparation of metal nanoparticles within spherical polymer nanoparticles through Flash NanoPrecipitation(FNP). Polystyrene-block-poly(vinylpyridine) (PS-b-PVP) in THF, aqueous metal ion salts, and reducing agent solutions are employed as polymer stream, non-solvent stream and collection solution, respectively. Uniform metal nanoparticles ...

Distributed Intelligence Architecture for Real-Time Control, Protection and Instrumentation Systems

jdrayton@princeton.edu — Mon, 25 Jul 2016 06:30:14 GMT

Princeton Docket # 16-3182-1 Researchers at Princeton Plasma Physics Laboratory have combined concepts of data flow prioritization management, cognitive neuroscience, and smart sensing to create a distributed intelligence network. Architecture of complex, high-speed, real-time Instrumentation, Acquisition, Control and Protection systems are typically centralized with a single computer. As the size of the system grows, or the complexity of the sensors and the amount of data increases, this single computer must be scaled accordingly. It complicates hardware selection and software...

Self-Aligning Mirror Mechanism for Transmission Line Offset Correction

jdrayton@princeton.edu — Wed, 13 Jul 2016 06:51:03 GMT

Selective C-H Fluorination of Organic Compounds Using an Earth-abundant Visible Light Photocatalyst

jdrayton@princeton.edu — Mon, 11 Jul 2016 14:01:43 GMT

Princeton Docket # 15-3146-1 Researchers in the Department of Chemistry at Princeton University have developed a new C-H fluorination method that uses uranium as a visible light photocatalyst. The fluorination of unactivated Csp3–H bonds remains a desirable, challenging transformation for pharmaceutical, agricultural, and materials scientists. Current methods for the C–H fluorination of unactivated substrates (e.g. alkanes) rely on either highly reactive oxidant species and/or the use of high energy ultraviolet light. This invention uses a modular visible lig...

Scanning Probe Lithography Using Non-Raster Trajectories

jdrayton@princeton.edu — Thu, 07 Jul 2016 11:56:55 GMT

Princeton Docket # 16-3186-1Researchers at Princeton University, PRISM Imaging and Analysis Center, have developed a new method for scanning probe lithography (SPL). This method has been developed with non-raster trajectories which can be synthesized by sine and cosine waveforms to drive the scanning process. Compared with the raster scan SPL, non-raster scan with smoother driving waveforms can speed up the fabrication process without exciting traditional scanner’s oscillation at higher-order harmonics. W...

Patterned Charge Generation Using Torsional Mode Atomic Force Microscopy

jdrayton@princeton.edu — Thu, 07 Jul 2016 11:53:05 GMT

Princeton Docket # 16-3203-1 Researchers at Princeton University, PRISM Imaging and Analysis Center, have developed a new in-situ nano-triboelectrification method to generate patterned triboelectric charges on insulating material surface. This method has been developed using torsional resonance mode atomic force microscopy (AFM). It can significantly increase (tenfold) the efficiency of generating patterned triboelectric charges over the conventional contact mode AFM. Moreover, it enables the tip to perform lateral oscillation during rubbing processes and keeps the tip-sample interac...

Novel Sample Pre-treatment Method for Improved Isotope Ratio Infrared Spectroscopy Measurement

jdrayton@princeton.edu — Fri, 24 Jun 2016 13:36:39 GMT

Princeton Docket # 16-3212-1 Researchers at Princeton University, Department of Civil & Environmental Engineering, have developed a method to reduce spectral interference of organic contaminants in isotope ratio infrared spectroscopy (IRIS) through the use of solid phase extraction (SPE) technique. IRIS is used for the stable hydrogen and oxygen isotope analysis of water sample. Volatile organic compounds (VOCs) such as methanol and ethanol in water samples which are extracted from plants can cause spectral interference in IRIS. This contamination reduces the accuracy of measurem...

Oocyte Quality Evaluation for Reproduction Prediction

jdrayton@princeton.edu — Fri, 17 Jun 2016 12:44:17 GMT

Princeton Docket # 15-3076-1Researchers in the Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton University have discovered biomarkers that are indicative of oocyte quality. This invention is a new diagnostic tool for female reproductive status that will use biomarkers of oocyte quality to predict a woman’s biological oocyte age and likelihood of conception. Reproductive decline, characterized by infertility, miscarriage, and birth defects, is attributed to declining oocyte quality with age. Women would like to be able t...

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water

jdrayton@princeton.edu — Thu, 09 Jun 2016 09:23:19 GMT

Docket # 15-3063-1 Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions without the input of external energy or the use of harsh chemicals, circumventing the major concerns of large-scale production of ClO2 as well as providing a low-tech, green option for water purification. This invention uses water-soluble iron porphyrazine catalysts capable of rapid conversion of ClO2- to ClO2. They are more sustainable and sup...

A Novel Design of Advanced Liquid Centrifuge Using Differentially Rotating Cylinders and Optimized Boundary Conditions

jdrayton@princeton.edu — Mon, 06 Jun 2016 07:14:33 GMT

Advanced Liquid Centrifuge Using Differentially Rotating CylindersPrinceton Docket # 12-2804Researchers in the Department of Astrophysical Sciences and Princeton Plasma Physics Laboratory, Princeton University have designed an advanced liquid centrifuge using differentially rotating cylinders and optimized boundary conditions. The unique design of the cylinders allows for an enhancement of separation efficiency over that of conventional centrifuges rotating at comparable speeds. The novel design of the advanced centrifugal contactor has an advantageous dual-purpose function combined in a...

An Architecture for Security Health Monitoring and Attestation in Cloud Computing

jdrayton@princeton.edu — Thu, 07 Apr 2016 08:12:31 GMT

Princeton Docket # 15-3171-1 Researchers at Princeton University, Department of Electrical Engineering, have developed a distributed architecture to monitor and attest the security health of cloud customers' virtual machines (VMs) in a cloud computing system. Cloud providers want to monitor VMs to provide a secure and efficient computing environment to their customers. But there are few security health monitoring mechanisms in today's clouds. In addition, current attestation mechanisms are not very powerful or efficient. Current attestation techniques only focus on the integrity of a...

OXIDATION CATALYSTS

jdrayton@princeton.edu — Mon, 21 Mar 2016 13:29:34 GMT

Researchers at Princeton University have synthesized a new family of robust inorganic catalysts suitable for industrially important oxidation reactions including electrochemical and photochemical conversion of water to hydrogen peroxide and oxygen, and the oxidation of chloride to chlorine. Previously, there were no commercially viable catalysts for the oxidation of water. The catalysts possess a cubical shaped Mn4O4 core that is isolable in multiple oxida tion states and stabilized by unique ligands that bridge across the six faces of the cube. One form of the catalyst employs novel...

Scalable, Highly Immunogenic, Polysaccharide-Peptide Nanoparticle Vaccine for Protection against Many Bacterial Serotypes

jdrayton@princeton.edu — Tue, 01 Mar 2016 12:14:00 GMT

Princeton Docket # 15-3168-1 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a new nanoparticle vaccine platform which enables nanoparticle functionalization with polysaccharides and immunogenic peptides, allowing for the possibility of nanoparticle functionalization with a number of different serotypes. The major cause of serious bacterial illness is infection by polysaccharide-encapsulated bacteria. Glycoconjugate vaccines have the potential to generate long-term immunity to these bacteria. The most commonly used vaccine ...

Highly loaded (Depot) Microparticle Delivery System for the Controlled Release of Aqueous Soluble Biologics and Therapeutics

jdrayton@princeton.edu — Tue, 01 Mar 2016 11:02:36 GMT

Princeton Docket # 16-3225-1Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a new method for synthesizing nanoparticles or microparticles comprised of aggregated nanoparticles having a hydrophilic core and a less polar shell. Biologically derived therapeutics, or biologics, are the most rapidly growing segment of the pharmaceutical marketplace. However, there are still unmet needs in improving the delivery of biologics. Injectable polymeric nanoparticles and microparticles capable of releasing proteins and peptides over time per...

New Tri(1-adamantyl)phophine Ligand for Improved Transition Metal Catalysis

jdrayton@princeton.edu — Wed, 27 Jan 2016 11:41:27 GMT

Princeton Docket # 16-3202-1 Researchers in the Department of Chemistry at Princeton University have developed a new ligand for cross-coupling reactions to use in conjunction with transition metal catalysts. Modern palladium catalysts for cross-coupling chemistry rely predominantly on phosphine or N-heterocyclic carbene ligands to enhance their reactivity towards industrially relevant substrates. However, many established ligands can suffer from undesired side reactions during a catalytic reaction, which affects the activity, selectivity, or stability of the metal catalyst. Tri(1-ad...

High Peak Power (≥ 10 mW) Quantum Cascade Superluminescent Emitter

jdrayton@princeton.edu — Fri, 08 Jan 2016 13:14:44 GMT

Princeton Docket # 15-3101-1 Researchers in the Department of Electrical Engineering at Princeton University have developed a novel Quantum Cascade (QC) device to emit mid-infrared (mid-IR) superluminescent light with high power output. The high power superluminescent light has applications in mid-IR broadband absorption spectroscopy and mid-IR optical coherence tomography (OCT). Superluminescent light sources have medical and industrial applications because of their intrinsically low temporal and good spatial coherence, smooth emission spectrum, and relatively high output powe...

A Novel Research and Diagnostics Tool for Monitoring the Anti-Proliferative Innate Immune Messenger (2-5A) In Vitro and In Vivo

jdrayton@princeton.edu — Wed, 06 Jan 2016 07:40:40 GMT

Princeton Docket # 16-3188-1 Researchers at Princeton University, Department of Molecular Biology, have developed a novel research and diagnostics tool for detection of an intracellular stress signal 2',5'-linked oligoadenylate (2-5A). 2-5A is a small RNA-like signal that activates the human receptor pseudokinase, RNase L. RNase L is a candidate tumor suppressor in hereditary prostate cancer and breast cancer. RNase L is key for antibacterial defense, antiviral defense, growth, insulin response and adipocyte differentiation. Researchers found that the RNase L•2-5A c...

Piezoelectric Dust Levitator

jdrayton@princeton.edu — Tue, 24 Nov 2015 12:24:57 GMT

Princeton Docket # 15-3098 Researchers at the Princeton University Plasma Physics Laboratory have developed a novel device that uses a piezoelectric disk to levitate small particles ranging from 10 nm to 1 mm in diameter. The piezoelectric dust levitator is capable of levitating commercially available nanoparticle powders, which can be used as a source for various volumetric optical diagnostics. In addition, the piezoelectric dust levitator provides a straightforward pathway to further research on nanoparticles in air without the interference of high electric or magnetic fields. App...

Vibration-Based Secure Side Channel for Medical Devices

jdrayton@princeton.edu — Mon, 16 Nov 2015 13:44:49 GMT

Princeton Docket # 15-3123 Advances in the design of implantable and wearable medical devices (IWMDs) have enabled fundamentally new options for monitoring, diagnosing, and treating a wide range of medical conditions. IWMDs have become increasingly sophisticated over the years and are now commonly equipped with advanced features, such as wireless connectivity. In addition to enabling continuous ambulatory monitoring, wireless connectivity in IWMDs also allows healthcare professionals to remotely monitor a patient's health and device status without requiring the patient to visit their offi...

Dynamic Models for Short-Term Wind Forecasting

jdrayton@princeton.edu — Wed, 11 Nov 2015 08:52:29 GMT

Dynamic Models for Short-Term Wind Forecasting Princeton Docket # 15-3145 Researchers in the Department of Civil and Environmental Engineering at Princeton University have developed a fundamentally new approach for short-term wind power forecasting. The new wind prediction model relies on a data-driven but physically-based approach that has successfully passed initial proof of concept tests. It is based on the extrapolation of the slowly-varying large scale forcing pressure gradients (rather than wind speed directly as is currently done) into the future, and then inferring the wind ...

Nano-Encapsulation Using GRAS Materials

jdrayton@princeton.edu — Wed, 28 Oct 2015 06:17:17 GMT

Nanoparticle Compositions and Methods using Gras Materials for encapsulation and delivery of active pharmaceutical ingredients Princeton Docket # 15-3169 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a new nano-encapsulation process using generally recognized as safe (GRAS) material. Through this novel synthesis process, components of the core and coating are kinetically assembled in a continuous, low-energy, self-contained micromixing system. The process uses amphiphilic, water-insoluble protein-based polymers such as the prol...

Enhanced Ultrasound Imaging

jdrayton@princeton.edu — Mon, 19 Oct 2015 13:12:14 GMT

Princeton Docket # 15-3096-1 Researchers at Princeton University, Department of Electrical Engineering, have proposed a method to improve ultrasound image quality. Ultrasound operates like radar, with a probe beam sent to the object and an echo recorded. 2D and 3D images are then built up point-by-point in a scanning fashion. In many cases, however, the resulting image has poor quality. This is especially true in biomedical ultrasound, as inhomogeneity in tissue causes a variety of problems. These problems become worse with increasing probe frequency and increasing sample depth. &n...

New Design for Reducing Hall Thrusster Chamber Wall Erosion

jdrayton@princeton.edu — Mon, 19 Oct 2015 12:44:16 GMT

Princeton Docket # 15-3066-1 Researchers at Princeton Plasma Physics Laboratory, Princeton University, have proposed a new design for extending the lifetime of hall thrusters. Hall thrusters have been established as a compact and reliable means for satellite applications. Erosion of the surfaces of such thrusters, however, has been a serious factor in limiting their lifetimes. Replacing eroded surfaces by replenishing them is generally unattractive because of the mechanical complexity. This invention addresses this concern using a lightweight material (liquid lithium) in a poro...

Electrical Detector for Detecting Liquid Metal leaks

jdrayton@princeton.edu — Mon, 12 Oct 2015 08:15:45 GMT

Princeton Docket # 15-3094-1 Researchers in the Department of Engineering at Princeton Plasma Physics Laboratory, Princeton University, have designed an electrical detector for detecting liquid metal leaks. Liquid metal has unique physical properties and many applications. For instance, liquid lithium is a candidate plasma facing component (PFC) material for a fusion reactor. Liquid lithium, liquid antimony alloys and liquid gallium electrodes can be utilized in liquid metal batteries and high-power electrical switches. Liquid metal leaks can be dangerous and hazardous. As a result,...

3-D Printed Patient-Specific Conduits for Complex Peripheral Nerve Injury

jdrayton@princeton.edu — Wed, 07 Oct 2015 08:41:26 GMT

Princeton Docket # 14-3008-1 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have developed a method to produce patient-specific biometic nerve conduit for complex nerve injury regenerations, including but not limiting to peripheral and central nervous system regenerations using 3D imaging and 3D printing techniques. Nerve regenerations such as peripheral nerve regeneration is an important field, as damage to peripheral nerves results to over 200,000 annual nerve repair procedures in the U.S. alone. A nerve guidance channel (NGC) is one ...

Random Fill Caching for Secure Caches

jdrayton@princeton.edu — Wed, 23 Sep 2015 12:03:52 GMT

Princeton Docket # 15-3105-1 Researchers at Princeton University, Department of Electrical Engineering, have developed a new cache fill strategy and cache architecture to secure the existing processor cache to prevent information leakage through cache side-channel attacks.Correctly functioning caches have been shown to leak critical secrets like encryption keys, through various types of cache side-channel attacks. This nullifies the security provided by strong encryption and allows confidentiality breaches, impersonation attacks and fake services. Hence, future cache designs must consider...

Speeding Up the Convergence of Network Devices Using Low-Cost SDN Switches

jdrayton@princeton.edu — Wed, 23 Sep 2015 07:36:16 GMT

Princeton Docket # 15-3153-1 Researchers at Princeton University, Department of Computer Science, along with researchers at ETH Zürich have proposed a solution to speed up the convergence time following a network equipment failure. Analyses show that an increase in network delay of a few hundred milliseconds can translate into millions of dollars of losses, therefore high network availability is especially important for those companies whose revenue directly depend upon network connectivity. Most network devices deployed today converges slowly upon link or node failures. On forwardin...

Enhanced Adjunctive Therapies for Microbial Infections and Imaging

jdrayton@princeton.edu — Tue, 22 Sep 2015 08:30:10 GMT

Princeton Docket # 16-3183-1 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a nanocarrier based approach to enable and enhance adjunctive therapies for microbial infections by simultaneous encapsulation and delivery of all components. Microbial infections have become increasingly difficult to treat due to the emergence of drug resistant microbes. It has been previously demonstrated that adjunctive therapies, which are therapies that use antimicrobial (AM) drugs along with antimicrobial adjuvants (AMA), can be used to better...

Surfaces for Drag Reduction

jdrayton@princeton.edu — Wed, 19 Aug 2015 13:23:41 GMT

Princeton Docket # 15-3149-1 Researchers at Princeton University, Department of Mechanical and Aerospace Engineering, have developed a method to reduce the drag on solid objects opposed to fluid flow. Most liquid repellent surfaces are superhydrophobic, which contain pockets of air within surface roughness. Traditional air-water drag reduction surfaces fail under even moderate hydrostatic pressures, upon physical damage, and when using low surface tension liquids such as crude oil. In particular, up to the present time none of the previous surfaces have been successful in reducing d...

Methods to Resist Shear- and Gravity-Driven Drainage of Liquid-Infused Surfaces

jdrayton@princeton.edu — Wed, 19 Aug 2015 13:18:58 GMT

Princeton Docket # 15-3089-1 Researchers at Princeton University, Department of Mechanical and Aerospace Engineering, have proposed an improvement to the current design and fabrication of liquid-infused surfaces. Rough or patterned surfaces, when chemically treated and infused with a lubricating, superhydrophobic liquid, have been shown to repel liquid. The unique properties of liquid-infused surfaces include omniphobicity, resistance to biofouling, promotion of surface condensation, inhibition of icing, and reduction of drag. However, infused surfaces may lose their novel propertie...

Novel Light Extraction Layers for Organic Light-emitting Diodes

jdrayton@princeton.edu — Thu, 13 Aug 2015 05:55:31 GMT

Princeton Docket # 15-3085-1 Researchers at Princeton University, Department of Electrical Engineering, have developed a new structure and fabrication methods to make light extraction films for organic light-emitting diodes (OLEDs) or other thin film LED structures. At present, a light extraction layer which consists of substrates and nanoparticles is employed to increase the efficiency of OLEDs. Nanoparticles have different refractive index from the surrounding substrate, and thus can scatter the light trapped in the substrate. This innovation describes a new structure for light ext...

Method for Cost Effective Molecular Separations and Process Optimization

jdrayton@princeton.edu — Tue, 11 Aug 2015 11:59:34 GMT

Method for Cost Effective Molecular Separations and Process Optimization Princeton Docket #13-2887/2975 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a multi-scale computational screening approach for identifying promising materials from databases for industrial separations. The approach is novel in that it selects the most cost-effective materials and optimal process conditions while satisfying important systems-level constraints, such as product purity and recovery. This is in contrast to previous met...

Behaviorally-motivated Innovation for Hand Hygiene and Infection Control

jdrayton@princeton.edu — Tue, 04 Aug 2015 11:56:37 GMT

Princeton Docket # 15-3154-1 Researchers at Princeton University, departments of psychology and public affairs, along with researchers at Sunnybrook Health Sciences Centre, Toronto, have co-developed a behaviorally motivated innovation for infection control and hand hygiene. Clinician failure to wash hands before interacting with patients is a well-recognized problem in the healthcare environment. Overall, hospital-acquired infections in the United States cause patient mortality and morbidity equating to about 100,000 deaths per year. Inadequate hand hygiene by health care workers is...

Uses and Synthesis of high quality WTe2, a Titanic Magneto Resistive Material

jdrayton@princeton.edu — Mon, 20 Jul 2015 06:25:00 GMT

Princeton Docket # 15-3071-1Researchers at Princeton University, Department of Chemistry, have developed a material with a very high magneto resistive (MR) effect, WTe2, which can be used in devices based on the MR effect. Magnetoresistance is the change of a material’s electrical resistance in response to an applied magnetic field. Materials with large magnetoresistance have been used as magnetic sensors, in magnetic memory, hard drives, and transistors. Currently, the materials used for temperature or magnetic field measurements are prone to large degrees of error when used below...

Blocking bacterial infection by inhibiting surface-regulated virulence induction

jdrayton@princeton.edu — Fri, 10 Jul 2015 08:39:06 GMT

Princeton Docket # 15-3090 Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. P. aeruginosa is a major cause of hospital-acquired infections, burn infections, and cystic fibrosis infections. The discovered mechanosensitive pathway is conserved in other pathogens, allowing this strategy to be exploited f...

Multibeam Radio Frequency Photonic Beamformer Using a Multi-Signal Slow Light Time Delay Unit

jdrayton@princeton.edu — Tue, 23 Jun 2015 08:43:28 GMT

Multi-beam Radio Frequency Photonic Beamformer using a Multi-Signal Slow Light Time Delay Unit Princeton Docket # 14-3049 Researchers in the Department of Electrical Engineering at Princeton University have developed a multi-beam simultaneous radio frequency (RF) photonic beamformer, focusing on the beamformer architecture, integrating a novel multi-beam slow time delay unit (TDU). A method of filtering radio frequency signals in the spatial and temporal domains using optics is achieved. Photonic RF beamformers can provide powerful radar, sensing, and communication ca...

Adaptive Cognitive Prosthetic

jdrayton@princeton.edu — Wed, 27 May 2015 07:17:52 GMT

Adaptive Cognitive Prosthetic to Treat Neurological and Neuropsychiatric Disorders and Traumatic Brain Injuries Princeton Docket # 14-3031 A researcher in the Princeton Neuroscience Institute and the Department of Psychology at Princeton University is developing a novel treatment approach for neurological and neuropsychiatric disorders. These neural disorders severely reduce the quality of life for those affected and carry significant societal and economic costs. The CDC estimates over 600,000 individuals in the United States experience a stroke each year, and over 275,000 indiv...

Novel Highly Scalable Adaptive Photonic Beamformer Using "Blind" Guided Accelerated Random Search

jdrayton@princeton.edu — Wed, 27 May 2015 06:46:22 GMT

Highly Scalable Adaptive Photonic Beamformer using “Blind” Guided Accelerated Random Search for Wireless Communication Princeton Docket # 15-3056 Researchers in the Department of Electrical Engineering at Princeton University have developed an adaptive photonic beamformer for use in wireless communication. Wireless communication has experienced an explosion of growth in the past decade, with smartphones, tablets, and WIFI- and Bluetooth-enabled devices becoming increasingly popular. The proliferation of smartphones with powerful processors and graphic chips ha...

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

jdrayton@princeton.edu — Wed, 13 May 2015 08:26:53 GMT

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and whole genome sequencing. The utility of this approach was demonstrated via the identification of the known CAN1 andTOP1 drug resistance targets for two compounds, canavanine and camptothecin, respectively. The sequencing of mito...

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

jdrayton@princeton.edu — Wed, 13 May 2015 08:26:50 GMT

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery of clinically approved drugs with previously unknown capacity to kill or selectively inhibit the growth of mismatch repair defective cells. Mismatch repair is a highly conserved DNA repair pathway that plays a key role in maintaining ge...

Sirt4 Lipoamidase Activity and Uses Thereof

jdrayton@princeton.edu — Tue, 21 Apr 2015 13:20:23 GMT

A Novel Assay for Sirtuin 4 (SIRT4) Lipoamidase Activity and the Activity of the Pyruvate Dehydrogenase Complex Princeton Docket # 14-3002 A novel assay for measuring the lipoamidase activity of SIRT4 in mammalian cells and tissue samples has been created. A procedure by which the lipoamide cofactor activity can be monitored in mammalian cells has been developed. Candidate agents to modulate the lipoamide cofactor can be identified with this research tool. Sirtuins (SIRTs) are a family of seven mammalian nicotinamide adenine dinucleotide (NAD)-dependent enzymes that gove...

ClpP is a Major Regulator in NO Stressed E Coli

jdrayton@princeton.edu — Tue, 24 Mar 2015 10:07:40 GMT

Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies Princeton Docket # 15-3064 Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets host-pathogen interactions, rather than vital cellular processes. Because nitric oxide is an important antimicrobial used by the immune system to disable pathogens, and the virulence of many pathogens depends on nitric oxide defense systems, the i...

Process for Encapsulating Soluble Biologics, Therapeutics, and Imaging Agents

jdrayton@princeton.edu — Wed, 18 Mar 2015 06:00:20 GMT

Process for Encapsulating Soluble Biologics, Therapeutics, and Imaging Agents Princeton Docket # 14-3045 The encapsulation and controlled release of peptides and bio-active materials is a significant challenge in the nanoparticle field. Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a novel "inverse" precipitation route to precipitate aqueous soluble species in a hydrophobic solvent, to crosslink the shell layer, and then to precipitate that construct into an aqueous medial to deposit a PEG biocompatible layer on ...

Process for Acceptorless Dehydrogenation of Alkanes Through Dual Catalysis

jdrayton@princeton.edu — Tue, 24 Feb 2015 10:16:36 GMT

Dual Base Metal Catalysis for Alkene and Hydrogen Production via Acceptorless and Selective Dehydrogenation of Alkanes Princeton Docket # 15-3117 Researchers in the Department of Chemistry at Princeton University have developed a new catalyst combination, comprising of a tungsten-based polyoxometalate and cobaloxime, in order to dehydrogenate alkanes to produce molecular hydrogen and alkenes, important petrochemical feedstocks. Saturated organic compounds may be dehydrogenated through the synergistic function of two base metal catalysts. Current methods for the acceptorless...

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

jdrayton@princeton.edu — Mon, 26 Jan 2015 11:37:54 GMT

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis proteins from complex biological samples. Protein phosphorylation plays a critical role in central metabolism and cell signaling and is one of the most common posttranslational modifications. Misregulation of protein phosphor...

Process for Large-Scale Free-Form 3D Printing

jdrayton@princeton.edu — Wed, 14 Jan 2015 10:46:58 GMT

Process for Large-Scale Free-Form 3D Printing Princeton Docket # 14-3040 Large-scale 3D printers have constraints which include being slow for mass production, not cost-effective, and limited in available printing materials. Researchers in the School of Architecture at Princeton University have developed a technique for increasing the viability of large-scale 3D printing. By leveraging material computation and the relationships between materials, the process allows for large volumes to be extruded more efficiently, drastically decreasin...

Novel Cell Line for Hepatitis B Drug Discovery and Research

jdrayton@princeton.edu — Wed, 14 Jan 2015 08:18:43 GMT

Novel Cell Line for Hepatitis B Drug Discovery and Research Princeton Docket # 15-3077 Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate the viral life cycles to be studied. Functional screens can be conducted to identify small molecule and/or biological inhibitors, which will ultimately lead to developing a curative agent for HBV and HDV. Worldwide, t...

A Method for Controlling Growth Instability in Template-Assisted Electrodeposition of Nanowires

jdrayton@princeton.edu — Fri, 12 Dec 2014 10:35:28 GMT

A Method for Controlling Growth Instability in Template-Assisted Electrodeposition of Nanowires Princeton Docket # 14-3021 The synthesis of nanowires for future electronics and energy applications requires scalability, density, reproducibility, and cost effectiveness. In this regard, template-assisted electrodeposition methods offer distinct advantages for synthesizing nanowires. However, the incomplete and unstable growth of nanowires presents a major challenge for such widespread applications. Researchers in the Department of Mechanical and Aerospace Engineering at Princeton Universi...

Polymer Janus Nanoparticles by Flash NanoPrecipitation

jdrayton@princeton.edu — Mon, 08 Dec 2014 11:26:38 GMT

Polymer Janus Nanoparticles By Flash NanoPrecipitation Princeton Docket # 14-2981 Janus particles are characterized by two physically distinct regions within or on the surface of the particle. Polymer Janus nanoparticles, in particular, contain at least two different polymer regions. At present, only a few ingenious routes for the generation of polymer Janus nanoparticles exist. These methods require cumbersome synthesis, multi-step procedures and/or lengthy process times. These processes are not scalable to produce commercial amounts of Janus particles. &n...

Stress-Based State of Health and Charge Measurement for Intercalation Batteries

jdrayton@princeton.edu — Fri, 07 Nov 2014 08:16:27 GMT

Stress-Based State of Health and Charge Measurement for Intercalation Batteries Princeton Docket # 12-2792 The determination of a battery’s state of charge (SOC) and state of health (SOH) are important for the power management system that relies on batteries as a power source, e.g., mobile phones, laptops, electric vehicles, grid level storage, etc. Despite its fundamental importance in battery systems, SOC and SOH measurements are not straightforward and remain an area of active research. Researchers in the Department of Mechanical and Aerospace Engineering at Princ...

Subword Permutation Instructions for Re-ordering Subwords in Multiple Registers in Processors

jdrayton@princeton.edu — Fri, 31 Oct 2014 13:12:40 GMT

Princeton Docket #00-1712-1 The method and system provides a set of permutation primitives for current and future 2-D multimedia programs which are based on decomposing images and objects into atomic units, then finding the permutations desired for the atomic units. The subword permutation instructions for these 2-D building blocks are also defined for larger subword sizes at successively higher hierarchical levels. The atomic unit can be a 2×2 matrix and four triangles contained within the 2×2 matrix. Each of the elements in the matrix can represent a subword of one or more bit...

Method and System for Performing Permutations with Bit Permutation Instructions

jdrayton@princeton.edu — Fri, 31 Oct 2014 13:12:40 GMT

Princeton Docket #00-1709-1 The present invention provides permutation instructions which can be used in software executed in a programmable processor for solving permutation problems in cryptography, multimedia and other applications. PPERM and PPERM3R instructions are defined to perform permutations by a sequence of instructions with each sequence specifying the position in the source for each bit in the destination. In the PPERM instruction bits in the destination register that change are updated and bits in the destination register that do not cha...

Fast Permutation Instructions for Processors based on the Butterfly Network (Cross Instruction)

jdrayton@princeton.edu — Fri, 31 Oct 2014 13:12:39 GMT

Princeton Docket #00-1711-1 The present invention provides permutation instructions which can be used in software executed in a programmable processor for solving permutation problems in cryptography, multimedia and other applications. The permute instructions are based on a Benes network comprising two butterfly networks of the same size connected back-to-back. Intermediate sequences of bits are defined that an initial sequence of bits from a source register are transformed into. Each intermediate sequence of bits is used as input to a subsequent permutation instruction. Permutat...

OMFLIP - Fast Permutation Instruction for Processor based on Omega and Flip Networks

jdrayton@princeton.edu — Fri, 31 Oct 2014 13:12:38 GMT

Princeton Docket #00-1710-1 The present invention provides permutation instructions which can be used in software executed in a programmable processor for solving permutation problems in cryptography, multimedia and other applications. The permute instructions are based on an omega-flip network comprising at least two stages in which each stage can perform the function of either an omega network stage or a flip network stage. Intermediate sequences of bits are defined that an initial sequence of bits from a source register are transformed into. Each intermediate sequence of bits...

System and Method for Processor-Based Security

jdrayton@princeton.edu — Fri, 31 Oct 2014 13:12:36 GMT

Princeton Docket #09-2533-1 A system and method for processor-based security is provided, for on-chip security and trusted computing services for software applications. Secure execution environments (compartments or enclaves) are provided for executing trusted software by a secure processor and a trusted hypervisor. Secure memory and secure storage are provided for the hypervisor and for the trusted software modules. Secure module interactions are provided, as well as the generation of a power-on key which can be used to protect memory in the event of a re-boot event. Lightw...

Integrated CMOS On-Chip Fluorescence Bio-Sensor and Microscopy System

jdrayton@princeton.edu — Thu, 30 Oct 2014 12:51:40 GMT

Integrated CMOS-based Single–chip Fluorescence Bio‐Sensor System Docket # 14-2990 Integrated, low‐cost and portable point‐of‐care diagnostic technology has the potential to bring transformative changes in healthcare by enabling early detection of diseases in a remote field setting, allowing timely and rapid treatment to the patient and facilitating a potential shift from curative medicine, to predictive, personalized, and preemptive medicine. Affinity‐based bio‐sensor technology based on selective interaction of different analytes for detection of proteins, DNA, toxins, bacteria, etc....

A New Design of Cache Memory in Computers that Improves Performance and Security

jdrayton@princeton.edu — Thu, 30 Oct 2014 12:48:37 GMT

Princeton Docket #09-2526-1 The invention is a new method of designing cache memories used in computers. It achieves best-in-class performance for various performance metrics, previously achievable only by different conventional cache architectures. In particular, it combines benefits of Fully-Associative caches and Direct-Mapped caches, in a novel way different from conventional Set –Associative caches. In addition, it also provides security from cache-based side-channel attacks, which can cause information leakage, such as leaking the secret key of ciphers implemented by software ...

Uses of Hyperthermal Atomic Beam for Low Temperature Diamond Growth

jdrayton@princeton.edu — Thu, 30 Oct 2014 06:58:08 GMT

Use of Hyperthermal Atomic Beam for Low Temperature Diamond Growth Princeton Docket #14-2959 High quality diamond films, currently grown only at high substrate temperatures, are desirable for their mechanical hardness, thermal conduction, electrical resistivity, durability and optical transparency. A low temperature process to produce such high quality films does not exist today, so these diamond films can only be applied to substrates that can withstand high deposition temperatures. Some of the properties of diamond can be found in other materials, but there are no known materials wit...

A General-Purpose Parallel Read Functional Unit That Can Accelerate Software AES Encryption and Decryption. Parallel Read Functional Unit for Microprocessor

jdrayton@princeton.edu — Thu, 30 Oct 2014 06:40:01 GMT

Princeton Docket #09-2534-1 This invention proposes a new functional unit to store constants and tables, and new instructions that can read multiple constants in parallel, to speed up the software processing of various algorithms, including the AES encryption and decryption algorithms. AES is the NIST’s Advanced Encryption Standard (AES) which replaced DES (Data Encryption Standard), and is widely deployed. The invention can be used in any microprocessor, embedded processor, cryptoprocessor, Application Specific Instruction Processor (ASIP), System of Chip (SOC), or any programmable...

Quantum Dot Micromaser

jdrayton@princeton.edu — Wed, 08 Oct 2014 06:16:45 GMT

Quantum Dot Micromaser Docket # 14-3032 Solid-state superconducting circuits are versatile systems in which quantum states can be engineered and controlled. Recent progress in this area has opened up exciting possibilities for exploring fundamental physics as well as applications in quantum information technology. In a series of experiments it was shown that such circuits can be exploited to generate quantum optical phenomena by designing superconducting elements as artificial atoms that are coupled coherently to the photon field of a resonator. ...

Spatially-Multiplexed Architecture for Short-Range Wireless Communication With Increased Capacity

jdrayton@princeton.edu — Tue, 16 Sep 2014 11:43:46 GMT

High Capacity Wireless Interconnect Architecture Docket # 14-2991 Metal-based interconnect traces on PCB boards serve as the most common method of chip-chip interconnects. However, the increasing need of computational power requires that the communication data-rate from the processor to the peripherals be scaled proportionately. Current methods of scaling of electrical interconnects to higher data rates are either limited by the available bandwidth density, energy cost and the circuit complexities in driving high-speed data through lossy physical traces, or form factor constr...

Disposable Vacuum Viewport Protector

jdrayton@princeton.edu — Tue, 16 Sep 2014 07:15:32 GMT

Disposable Vacuum Viewport Protector Princeton Docket #14-3022 Industry and research facilities face unwanted vacuum viewport coating issues. For example, during low temperature plasma experiments, metallic films can develop on vacuum viewports, obscuring observation. The impaired viewports can either be replaced, which is costly, or cleaned. The cleaning of viewports requires a sequence of time-consuming procedures and may not be able to fully recover the transparency of the viewports. Researchers at the Princeton Plasma Physics Laboratory at Princeton University have developed...

A Framework for CO2 Capture, Utilization and Sequestration (CCUS) Supply Chain Network Optimization

jdrayton@princeton.edu — Wed, 20 Aug 2014 07:19:24 GMT

A Novel Tool for CO2 Capture, Utilization and Sequestration (CCUS) Optimization Docket # 14-3004 Stationary CO2 sources, including coal and natural gas power plants, iron and steel mills, and agricultural production, emit about 3 billion tons CO2 each year in the U.S. alone, which is released into the atmosphere where it contributes to global climate change. Meanwhile, CO2 demand for utilization options such as enhanced oil recovery is satisfied by producing CO2 from natural sources. CO2 capture, utilization and sequestration (CCUS) is a promising technology to manage CO2 emissions by extract...

Transition Metal Catalysts for Olefin Polymerization

jdrayton@princeton.edu — Mon, 28 Jul 2014 06:46:54 GMT

Transition Metal Catalysts for Olefin Polymerization Princeton Docket # 14-3038 Presently, only free radical copolymerizations of ethylene and polar industrial monomers (e.g, vinyl acetate or acrylic acid) at high temperatures and very high pressures have been commercialized. This existing technology, however, inherently lacks precise control over the resulting polymer microstructure and precludes access to highly linear (co)polymers. It is therefore advantageous to develop alternative synthetic methods in which material properties can be tuned at will. Researche...

Method for Cost Effective Molecular Separations and Process Optimization

jdrayton@princeton.edu — Thu, 17 Jul 2014 08:00:25 GMT

A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015

jdrayton@princeton.edu — Mon, 30 Jun 2014 05:52:59 GMT

A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015 Princeton researchers in the department of chemistry together with colleagues at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School have developed the first late-stage 18F labeling chemistry for aliphatic C-H bonds with no-carrier-added [18F]fluoride. The method uses Mn-salens or Mn-porphyrins as F-transfer catalysts and enables the facile labeling of a variety of bioactive molecules and build...

Fueling Method for Small, Steady-State, Aneutronic FRC Fusion Reactors

jdrayton@princeton.edu — Mon, 23 Jun 2014 08:06:06 GMT

Fueling Method for Small, Steady-State, Aneutronic FRC Fusion Reactors Princeton Docket # 14-2962 Researchers at the Princeton Plasma Physics Laboratory at Princeton University have disclosed a method to efficiently supply controlled and accurately timed amounts of deuterium and the rare element, 3He, to the core of small field-reversed-configuration (FRC) fusion reactors. This method is an essential procedure for these fusion reactors, enabling steady power production and very low levels of radioactivity. Conventional fueling methods, e.g., gas puffing or frozen-pellet or CT inje...

A Novel Adjuvant for Improved Immunological Stimulation

jdrayton@princeton.edu — Mon, 09 Jun 2014 11:43:40 GMT

Princeton Docket # 14-3007 Researchers in the Department of Molecular Biology at Princeton University have isolated a mutant strain of Escherichia coli that is specifically more resistant to vancomycin than is its wild-type parent. The resistance mutation in this strain alters an enzyme normally involved in LPS biosynthesis causing it to synthesize LPS molecules that are modified with peptidoglycan cell wall fragments (PG). This altered LPS glycoform (LPS*) displays vancomycin-binding sites at the cell surface that act as extracellular decoys and that increase resistance by...

Multi-Harmonic Inline Reference Cell for Optical Trace Gas Sensing

jdrayton@princeton.edu — Thu, 29 May 2014 07:28:46 GMT

Multi-Harmonic Inline Reference Cell for Optical Trace Gas Sensing US Patent 2014/0049777 A1 - Issued 20 February 2014: https://www.google.com/patents/US20140049777?dq=2014/0049777&hl=en&sa=X&ei=KjyHU46NFdPesATwkIGAAw&ved=0CDUQ6AEwAA

A System for Human-Machine Multi-Disciplinary Design Optimization

jdrayton@princeton.edu — Mon, 12 May 2014 05:49:27 GMT

A System for Human-Machine Multidisciplinary Design Optimization Princeton Docket #14-3019 Multidisciplinary Design Optimization (MDO) is a powerful engineering tool that allows designers to incorporate information from all relevant design disciplines simultaneously. In aerospace applications, for example, MDO has been used to produce designs that incorporate both the structural and aerodynamic disciplines. It is not generally possible to optimize the objectives of all disciplines simultaneously, so producing an optimal design requires a human designer to balance the tradeoffs betw...

Display of Tournament Bracket

jdrayton@princeton.edu — Mon, 12 May 2014 05:49:22 GMT

Display of Tournament Bracket Princeton Docket #14-2969 Researchers at Princeton Plasma Physics Laboratory at Princeton University have developed a display system which gives sports and academic tournament organizers a very powerful tool for managing and communicating the results of every match. An electronic display of the tournament brackets is provided. An entire 32 team double elimination tournament can be shown on a single high definition screen. The presentation is formatted for display in a web browser on a computer. A high resolution screen can show the...

Process for Administering Distributed Academic Competitions

jdrayton@princeton.edu — Mon, 12 May 2014 05:49:15 GMT

Process for Administering Academic Competitions Princeton Docket #09-2564 Academic competitions, such as a “Science Bowl,” involve dozens of teams. Several matches are played simultaneously in different rooms on the site. Administering the match and advancing teams to subsequent rounds is challenging. Researchers at Princeton Plasma Physics Laboratory at Princeton University have developed a process which articulates and streamlines the process while enhancing the awareness of players, officials, and spectators. The displayed presentation of the scoreboard clo...

Production of Biofuels, Biomaterials and Sugar Alcohols (Polyols) by a Recombinant Microorganism Expressing Enzymes (Det1 and Pho13) for NADPH Upregulation and Polyol Phosphatase (Ynl010w) for Polyol Phosphatase Dephosphorylation

jdrayton@princeton.edu — Mon, 28 Apr 2014 07:26:23 GMT

A New Enzyme and Process for Metabolic Engineering of Production of Sorbitol, Mannitol, Ribitol, Xylitol, Arabitol, Erythritol, and Other Polyols Princeton Docket # 13-2939 Scientists in the Lewis-Sigler Institute, Princeton University have discovered an enzyme which encodes a broad-spectrum, D-stereoisomer-specific sugar alcohol phosphatase, which has high activity against sorbitol-6-phosphate, mannitol-6-phosphate, ribitol-5-phosphate, xylitol-5-phosphate, arabitol-5-phosphate, and erythritol-4-phosphate. This is the first known enzyme to catalyze specific hydrolysis of t...

Measuring Thin Film Flows Using FRAP

jdrayton@princeton.edu — Thu, 17 Apr 2014 12:08:01 GMT

Measuring Thin Film Flows Using FRAP (Fluorescence Recovery After Photobleaching) Princeton Docket #14-2963 Industrial coating, painting, and printing processes all involve a thin liquid film flowing over a solid surface. To properly design an industrial system containing these processes, it is necessary to understand the characteristics of the flow in these films. Current methods, such as Particle Image Velocimetry (PIV) and Laser Doppler Velocimetry (LDV) techniques, are limited in their practicality and usefulness. These techniques both require expensive specialized equipment and c...

DNA Barcoding of Designer Mononucleosome and Chromatin Array Libraries for the Profiling of Chromatin Readers, Writers, Erasers, and Modulators Thereof

jdrayton@princeton.edu — Wed, 09 Apr 2014 12:46:31 GMT

Chromatin Biochemistry Using Barcoded Nucleosome Libraries A Versatile Platform to Screen and Identify Epigenetic Signaling Pathways and Drug Targets Princeton Docket # 12-2822 Researchers at Princeton University have developed a biochemical strategy to decipher chromatin signaling based on the streamlined preparation of DNA-barcoded nucleosome libraries (‘DNLs’) with distinct combinations of PTMs. These histones are accessible through recombinant (for unmodified histone variants) and protein semi-synthesis technology (for chemically pure, modified histones), the key...

Iodine-Based Nanoparticles for Diagnostic Medical Imaging Applications

jdrayton@princeton.edu — Tue, 01 Apr 2014 14:24:41 GMT

Iodine-Based Nanoparticles for Diagnostic Medical Imaging Applications Princeton Docket # 14-2943 Non-invasive medical imaging techniques such as X-ray-Computed Tomography (CT) and Positron Emission Tomography (PET) are powerful tools in diagnostic medicine. In these applications, contrast agents are needed to enhance the diagnostic quality of the images. Ideally, contrast agents would be biocompatible and contain high payloads of contrast agent. Thus, nanoparticle formulations of radiopaque or radioactive materials offer opportunities for improvements in diagnostic...

DataSafe - A Hardware-Software Architecture for Self-Protecting Data

jdrayton@princeton.edu — Tue, 01 Apr 2014 14:24:36 GMT

Princeton Docket #14-2960 Computer applications are downloaded frequently from unknown sources. One has to trust that the applications do not do anything harmful. In cloud computing, third-party applications are frequently used, like analytics or management programs, to process proprietary or high value data. If these applications are allowed to process confidential or sensitive data, one has to trust that they do not intentionally or inadvertently leak data. Similarly, many applications are downloaded into smartphones from App stores. Smartphone users may give per...

Method for Controlling of Spatial and Temporal Variations of Plasma Properties in Plasma Devices With Crossed Electric and Magnetic Fields

jdrayton@princeton.edu — Fri, 14 Mar 2014 13:09:50 GMT

Method for Controlling the Spatial and Temporal Variations of Plasma Properties in Plasma Devices with Crossed Electric and Magnetic Fields Princeton Docket # 14-2954 Researchers in the Princeton Plasma Physics Laboratory at Princeton University have proposed a new method of crafting spatial variations of the electron cross-field transport to control macroscopic plasma properties, including the electron field, electron temperature and plasma density, and their spatial distributions in relevant E cross B plasma devices such as Hall and helicon plasma thrusters, and plasma-beam devices fo...

Graphene Excitable Laser for Photonic Spike Processing

jdrayton@princeton.edu — Tue, 04 Mar 2014 11:58:35 GMT

Graphene Excitable Laser Princeton Docket # 14-2965 Researchers in the Department of Electrical Engineering at Princeton University have demonstrated a novel excitable laser employing passively Q-switching with a graphene-based saturable absorber (SA). Princeton is seeking an industry collaborator to commercialize this technology. Graphene, a Nobel Prize winning material, is a 2D layer of carbon atoms arranged in a honeycomb lattice that exhibits remarkable electrical and optical properties. Unlike previous absorbers based on semiconductor materials, the laser based on the op...

Fast Response Humidity Sensor

jdrayton@princeton.edu — Tue, 04 Mar 2014 10:39:44 GMT

Fast Response Humidity Sensor Princeton Docket # 14-2947 Researchers in the Department of Mechanical and Aerospace Engineering at Princeton University have developed a fast response humidity sensor. Conventional humidity sensors rely on principles such as radiation absorption or capacitance of the air. This new sensor produces high frequency humidity measurements indirectly through high frequency thermal conductivity measurements. Accurate measurements of energy fluxes in the atmosphere can be made, since the thermal conductivity of air is a strong function of humidity. The device ...

Noninvasive Mid-Infrared In Vivo Glucose Sensor

jdrayton@princeton.edu — Tue, 28 Jan 2014 06:25:55 GMT

Noninvasive Mid-infrared in vivo Glucose Sensor Princeton Docket # 14-2945 Researchers in the Department of Electrical Engineering at Princeton University have developed a novel, noninvasive method to measure blood glucose levels. Development of this noninvasive in vivo glucose sensor may improve the quality of life for the more than 343 million diabetics worldwide who need to monitor their blood glucose levels frequently. This novel method measures glucose concentrations in dermal interstitial fluid, which is known to have excellent correlation with blood glucose levels. Accurate no...

Distributed Storage Using Similarity-Aware-Partitioning

jdrayton@princeton.edu — Mon, 13 Jan 2014 12:55:48 GMT

Distributed Storage Using Similarly-Aware-Partitioning Princeton Docket # 14-2948 Data volumes are increasing at an unprecedented rate due to the advent of large social networks, on-demand cloud-based video services, and file sharing applications. To store and access data efficiently, there has been an increased demand for distributed data stores. These storage services face an ever-increasing demand on their systems and must satisfy two important concerns: they should be space-efficient to manage the high volumes of data, and they should be access-efficient in terms of minimizing ...

Novel Method for the Production of Upgraded Water From Saline, Brackish and Polluted Water

jdrayton@princeton.edu — Mon, 13 Jan 2014 12:55:43 GMT

Novel Method for the Production of Upgraded Water from Saline, Brackish and Polluted Water Princeton Docket # 12-2722/2817 The growing shortage of fresh water is a problem of international concern. Methods for upgrading sea water make an important contribution to the fresh water supply. Current large-scale methods for upgrading sea water are by reverse osmosis and flash-distillation, the latter being used primarily where thermal energy is cheaply available. Reverse osmosis is approaching its practical economic limit because of the energy required to force water through the osmosis membra...

A Novel Objective for EUV Microscopy and EUV Lithography

jdrayton@princeton.edu — Mon, 13 Jan 2014 12:07:12 GMT

A Novel Objective for EUV Microscopy and EUV Lithography Princeton Docket # 14-2950 Researchers at Princeton Plasma Physics Laboratory (PPPL) have proposed a novel device for extreme ultraviolet (EUV) spectroscopy, EUV microscopy, and EUV lithography at wavelengths below 100 nm. Princeton is seeking an industry partner to develop and commercialize this technology. This new EUV device consists of two concentric, concave and convex spherical mirrors or reflectors and can be assembled and aligned using standard procedures for the assembly and alignment of optical components. ...

An Efficient, Green Process for Cyanide Decontamination in Water

jdrayton@princeton.edu — Thu, 09 Jan 2014 05:42:12 GMT

An Efficient, Green Process for Cyanide Decontamination in Water Princeton Docket # 14-2955 This innovation is an improvement to a previously patent pending process for the catalytic generation of chlorine dioxide, Princeton docket # 11-2630/2714, US Patent Publication 2013-0209573, “An Efficient, Catalytic and Scalable Method to Produce Chlorine Dioxide” which refers to a manganese catalyzed process for the production of chlorine dioxide. Continuing their research with manganese catalysts, chemists at Princeton University have identified a novel improvement for gen...

A new energy efficient method for the removal of nitrogen for wastewater management and engineered wetlands

jdrayton@princeton.edu — Fri, 08 Nov 2013 13:07:05 GMT

A new energy efficient method for the removal of nitrogen for wastewater management and engineered wetlands Princeton Docket # 13-2918 Researchers in the Department of Civil and Environmental Engineering, Princeton University, have identified a new microorganism that is responsible for the Feammox process. Virtually all wastewater treatment plants in the developed world as well as in many developing countries oxidize NH4+ to NO3- before discharging the treated wastewater. This is done to decrease oxygen demand in the receiving waters. Biological ammonium oxidation ...

Methods for the Design of Amorphous Semiconductors with Unique Band Gap Properties for Distinctive Electronic and Phononic Transport Properties

jdrayton@princeton.edu — Wed, 06 Nov 2013 05:08:49 GMT

Methods for the Design of Amorphous Semiconductors with Unique Band Gap Properties for Distinctive Electronic and Phononic Transport Properties Princeton Docket # 13-2914 Research in the department of chemistry and department of physics, Princeton University, has led to improved methods for controlling and altering band gaps in commercially useful materials such as amorphous silicon, germanium and diamond. These methods can be used in the design of isotropic semiconducting materials which are used in a wide range of electronic applications such as photovoltaic cells, x-ray ...

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications

jdrayton@princeton.edu — Fri, 01 Nov 2013 05:55:36 GMT

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of Cellular Motility, Migration, and/or Invasion Princeton Docket # 13-2929-1 High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple mRNAs and peptides as a result of alternative splicing and/or polyadenylation events. Researchers in the Department of Molecular Biology, Princeton University, have identified a gene from which two distinct mRNAs are transcribed. These two iso...

Granular Composite Density Enhancement Process

jdrayton@princeton.edu — Tue, 22 Oct 2013 08:13:52 GMT

Granular Composite Density Enhancement Process Princeton Docket # 12-2827 Researchers in the Department of Chemistry at Princeton University and Princeton Institute for the Science and Technology of Materials have developed a novel process to substantially decrease the amount of cement required for and therefore the cost of concrete production, increase the density, strength, and longevity of concrete, increase the density and thrust of solid propellants, and increase the density and strength of granular armors and ceramics. This novel approach is to tailor the mixing of granular c...

Method for Cost Effective Molecular Separations and Process Optimization for Carbon Dioxide/Methane Separation

jdrayton@princeton.edu — Fri, 18 Oct 2013 05:38:49 GMT

Method for Cost Effective Molecular Separations and Process Optimization for Carbon Dioxide/Methane Separation Docket # 14-2975 Researchers in the Department of Chemical and Biological Engineering, Princeton University, have developed a multi-scale computational screening approach for identifying promising materials from databases for the purification of natural gas. The approach is novel in that it selects the most cost-effective materials and optimal process conditions while satisfying important systems-level constraints, such as product purity and recovery. This is in ...

Methods for the Discovery of Therapeutic Proteins and Peptides with Post-Translational Modifications and Non-Canonical Amino Acids

jdrayton@princeton.edu — Fri, 27 Sep 2013 07:55:50 GMT

Methods for the Discovery of Therapeutic Proteins and Peptides with Post-Translational Modifications and Non-Canonical Amino Acids Princeton Docket # 13-2924 Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a novel computational framework to design proteins and peptides with a large library of post-translational modifications (PTMs) and noncanonical amino acids (NCAAs) for use in drug discovery. Many new proteins being commercialized for drug applications increasingly contain post-translational modifications and noncanonical amino...

Systems Based Method for the Identification of Next Generation Anti-Infective Compositions

jdrayton@princeton.edu — Wed, 28 Aug 2013 13:10:05 GMT

Systems based Method for the identification of Next Generation Anti-Infective Compositions Princeton Docket # 13-2870 Researchers in the department of chemical and biological engineering, Princeton University have discovered that engaging futile cycles in microbes increases bacterial death due to oxidative stress by orders of magnitude. Additionally they have developed a computational framework to direct selection of futile cycles under specified environmental conditions to produce antibacterial effects. Proof of concept in E. coli has been established for several futile cycl...

Improved-Resolution Light-Field Imaging

jdrayton@princeton.edu — Wed, 31 Jul 2013 12:40:52 GMT

Improved-Resolution Light-Field Imaging Princeton Docket # 13-2912-1 The Princeton researchers have developed a new method to improve the currently available light-field imaging. A novel feature is that this method can go beyond the resolution limit of current light-field imagers. The resolution of the current light-field imaging system, both lateral and axial, is limited by the size and the numerical aperture of the microlenset and the pixel size of wavefront sensor. This improved light-field Imaging system takes a full-resolution image from a conventional camera as prio...

Microfluidic Synthesis of Crimped Fibers

jdrayton@princeton.edu — Wed, 31 Jul 2013 07:44:04 GMT

Microfluidic Synthesis of Crimped Fibers Princeton Docket # 13-2885-1 Researchers at Princeton University have developed a microfluidic approach to synthesize crimped microfibers. Under this new method the entire process is carried out on one small microfluidic chip, permitting ease and a degree of control in tailoring the dimensions and extent of crimp superior to current processes. This method can also be used for the fabrication of other micro-objects and microfibers with other morphological features, such as flat ribbon-like structures. Using this method, the microfiber is s...

Enhanced 3D Display

jdrayton@princeton.edu — Mon, 29 Jul 2013 08:55:23 GMT

Enhanced 3D Display Princeton Docket 13-2935-1 Researchers at Princeton University have developed a novel device that enhances the angular resolution available for 3D displays. Enhanced layered 3D is a low-cost method for increasing the fidelity of glasses-free 3D displays. This method allows for more variation of images to be experienced by multiple viewers. It enables advertisers to create lower cost and more varied 3D advertisements. Princeton is seeking a commercialization partner to license this technology. In the enhanced layered 3D display technology, the lens brings the far...

Formation of Nano-Emulsions by Bursting Bubbles in a Liquid-Liquid Interface

jdrayton@princeton.edu — Fri, 26 Jul 2013 15:34:15 GMT

A Novel and Low-Cost Method for Nano-emulsion Preparation Princeton Docket # 13-2871-1 Nano-emulsions are used in novel multiphase materials for home and personal care products, drug-delivery applications, structured liquids, etc. However, current methods for the preparation of nano-emulsions require either high-energy methods or sophisticated devices. To improve current methods and reduce the cost, researchers at Princeton University have developed a simple and low-cost method for the formation of nano-emulsions by bubble bursting at a liquid-liquid interface. This novel nano-emulsion ...

Creation of Multi-Functional Hybrid Devices/Structures by Three Dimensional Integration of Individual Components Using 3D Printing

jdrayton@princeton.edu — Fri, 26 Jul 2013 14:14:04 GMT

Creation of Multi-functional Hybrid Devices/Structures by Three Dimensional Integration of Individual Components using 3D Printing Princeton Docket 13-2861-1 Researchers at Princeton University have developed a novel process to provide three dimensional manufacturing of object containing various functionalities including light emitting diodes, transistors, biological tissues, and mechanical scaffolds etc. in a precise 3D architectural geometry prescribed by a CAD file from materials of various properties and functions, including electronic, mechanical, and biological functions. Pr...

System for 3-D Position and Gesture Sensing of Human Hand

jdrayton@princeton.edu — Tue, 23 Jul 2013 15:17:18 GMT

Novel System for 3D Position and Gesture Sensing of Human Hand Princeton Docket 13-2923-1 Researchers at Princeton University have developed a new touchless 3D gesture and control system for electronic devices including tablets, PCs and smart phones. The system consists of a new hardware device with interfacing software. This novel system has advantages over the current technologies in both accuracy and sensitivity. Princeton is now seeking a commercialization partner to license the technology. Currently there are three technologies used for 3D bare-hand pr...

Linear-Translational Multi-Target Manipulator with Adjustable Temperature Control for Thin Film Deposition

jdrayton@princeton.edu — Tue, 23 Jul 2013 15:03:10 GMT

Linear-Translational Multi-Target Manipulator with Adjustable Temperature Control for Thin Film Deposition Princeton Docket # 13-2931-1 Multi-target manipulators are one of the crucial parts in multi-layered film depositions such as Pulsed Laser Deposition (PLD). The complicated motion of the currently manufactured rotary multi-target manipulator prevents the targets from having an effective thermal contact with any type of heat sink, making it difficult to adjust the temperature of the existing multi-target manipulators. Adjustable temperature control of targets is required for some fil...

Fast Method for Nonlinear Fourier Analysis on the Line

jdrayton@princeton.edu — Wed, 12 Jun 2013 16:46:22 GMT

Fast Method Nonlinear Fourier Analysis for Optical Communication Systems Princeton Docket 13-2868-1 Researchers at Princeton University have developed a new fast nonlinear Fourier algorithm for use in optical communication systems. Recent research in the industry has proposed using nonlinear Fourier transform for the extraction of data from the received signal. Similar to the orthogonal frequency division multiplexing (OFDM) used in modern wireless systems, the nonlinear Fourier transform is used to embed data in the eigensignals of the nonlinear channel in this system. Pr...

A New Material for Solar Energy Conversion Devices

jdrayton@princeton.edu — Wed, 12 Jun 2013 14:07:10 GMT

A New Material for Solar Energy Conversion Devices Princeton Docket # 13-2905-1 To reduce the cost and improve the efficiency of current solar energy conversion devices, researchers at Princeton University have developed a novel material with improved features. This novel material is fabricated by alloying nickel oxide (NiO) with lithium (Li) in a rocksalt structure. The alloying of the material decreases the band gap of NiO to the optimal band gap for efficient absorption of visible sunlight. NiO:Li2O alloys preserve the charge transfer property of the host material, NiO. Charge carrie...

Double-Caged GABA: A Novel Light-Activated Probe as a Neuroscience Research Tool

jdrayton@princeton.edu — Wed, 29 May 2013 12:40:08 GMT

Double-caged GABA: A Novel Light-activated Probe as a Neuroscience Research Tool Princeton Docket # 13-2896-1 Researchers at Princeton University, Departments of Molecular Biology and Chemistry, have developed a light-activated probe that can be used as a neuroscience research tool. Current methods of probing neural activity such as microelectrode stimulation are limited by the invasiveness of inserting probes, but optical methods offer a powerful noninvasive al...

Novel Lasso Peptides as Molecular Scaffolds for Protein Therapeutics, Molecular Sensors and Probes

jdrayton@princeton.edu — Tue, 28 May 2013 14:00:55 GMT

Researchers at Princeton University, in the Department of Chemical and Biological Engineering, have engineered a gene cluster which encodes for the biosynthesis of a natural peptide product called Astexin-1. Astexin-1 is a new member of the lasso peptide class. Molecules of this class are highly stable, engineerable and may be utilized as molecular scaffolds for a variety of applications, such as in protein therapeutics and as molecular probes and sensors. An additional advantage of using lasso peptides as a scaffold for peptide drugs is the relative ease of production and purificatio...

Visualization of Multivariate Data

jdrayton@princeton.edu — Tue, 14 May 2013 11:41:23 GMT

Novel Tool for Visualization of Multivariate Data Princeton Docket # 13-2856-1 Researchers at Princeton University have developed novel visualization software to enable comparing and analyzing variables from large complex datasets. Princeton is seeking a commercial partner to license the technology. Representing trivariate and higher order data visually is challenging because multiple samples can overlap and obscure the visualization. This new software overcomes this limitation and enables unambiguous display of data points with multiple variables. This type o...

Optimization of the Configuration of Pixilated Detectors for the X-Ray Spectroscopy of Hot Plasmas Based on the Shannon-Nyquist Theorem

jdrayton@princeton.edu — Mon, 29 Apr 2013 10:53:10 GMT

Optimization of the Configuration of Pixilated Detectors Princeton Docket # 12-2829 Inventors from Princeton University's Plasma Physics Lab have developed a novel method of optimizing the configuration of pixilated radiation detectors, such that radiation in different x-ray energy ranges can be simultaneously recorded by a single detector. In order to detect spectra from multiple ion species or radiation in different energy ranges, existing technologies require separate spectrometers and detectors for each ion species. To maximize efficiency and minimize cost in x-ray spectroscopy, ...

Dual-Modulation Faraday Rotation Spectroscopy

jdrayton@princeton.edu — Mon, 29 Apr 2013 08:39:28 GMT

DUAL-MODULATION FARADAY ROTATION SPECTROSCOPY Princeton Docket # 12-2818-1 Researchers at Princeton University have developed a new method for simultaneously monitoring multiple paramagnetic species with high sensitivity and selectivity. A new dual modulation/demodulation process is applied to perform Faraday rotation spectroscopy (DM-FRS). The system comprises of laser source (or multiple laser sources), a shared optical configuration, and a signal acquisition and processing unit. The carrier fr...

Soluble Low-Density Lipoprotein Receptor Related Protein 4 as a Non-Invasive Biomarker for Age Determination for Commercially Fished Verebrates and Invertebrates

jdrayton@princeton.edu — Mon, 25 Mar 2013 13:50:59 GMT

Soluble low-density lipoprotein receptor related protein 4 (sLRP4) as a non-invasive biomarker for age Princeton Docket # 13-2884-1 Researchers at the Bermuda Institute of Ocean Sciences have discovered that sLRP4 may be useful as a biomarker for age determination in commercially fished invertebrates or vertebrates. Estimating age of commercially important species is a key part of effective management of sustainable fisheries. Age data is necessary for stock assessments, and to develop management or conservation plans. However current ...

Selective Fluorination of Drug Molecules for Higher Potency, Improved Pharmacology and Lower Metabolic Burden

jdrayton@princeton.edu — Thu, 21 Mar 2013 12:46:53 GMT

Princeton Docket # 12-2797/2758-1Chemists in the laboratory of Professor John T Groves, Princeton University have discovered a powerful, simple and potentially disruptive technology for drug diversification through direct fluorination (3D-F). Fluorine is a highly desirable drug component because replacement of hydrogen with fluorine usually results in higher potency, better pharmacology, and lower metabolic burden to the patient. As a result an increasing fraction of new drug entities, as well as agrochemical compounds, contain fluorine. Another important driver for fluorinated drugs comes fro...

Three Dimensional Multi-resolution Microscope (3DMM) for High-definition Imaging of Cell-biological Events

jdrayton@princeton.edu — Thu, 14 Mar 2013 13:22:20 GMT

Docket # 13-2834-1 The market for biological microscopes is greater than $1 billion annually. There is a high demand in the biomedical research field for microscopes which are capable of resolving ever smaller features and faster dynamics in live cells. However, currently available biological microscopes are limited in their ability to follow phenomena which evolve rapidly, in three dimensions, and over multiple length scales. To fill this market need, researchers in the department of Chemistry at Princeton University have developed the Three Dimensional Multi-resolution micro...

A Novel Automated Computational Method for Calculating Atomic Mappings for Chemical Reactions

jdrayton@princeton.edu — Tue, 05 Mar 2013 10:45:14 GMT

A novel automated computational method for calculating atomic mappings for chemical reactions Princeton Docket # 13-2860-1 Researchers at Chemical and Biological Engineering in Princeton University have developed a novel method for computing atomic mappings for chemical reactions. Reaction mapping can be used to infer which bonds break and form and thus implies a possible chemical reaction mechanism. It is also important for the calculation of chemical kinetics and the generation of transition state structures. Reaction mapping methods have gre...

Microfluidic Device for the Study and Treatment of Biofilm Formation in Environmental, Medical, or Industrial Devices

jdrayton@princeton.edu — Fri, 01 Mar 2013 13:29:14 GMT

Methods and Microfluidic Device for the Study, Testing and Treatment of Biofilm Formation in Environmental, Medical, or Industrial Devices Docket # 13-2880 Researchers at Princeton University have developed a microfluidic system and method to investigate biofilm morphologies under more realistic physical conditions which could be used to screen potential inhibitors of biofilm formation or to optimize the engineering of such devices prone to biofilm formation. The system, comprises a fluid flowing along the channel driven by a controlled pressure, which can measure biofilm and/...

Voluntary Head Restraint and Automated In Vivo Imaging System

jdrayton@princeton.edu — Tue, 26 Feb 2013 11:34:18 GMT

Voluntary Head Restraint and Automated in vivo Imaging System Princeton Docket #13-2837-1 Researchers at Department of Molecular Biology and the Princeton Neuroscience Institute, have developed a rat operated kinematic restraint clamp and automated in vivo imaging system. In neurosciences, measurement of neural activity in animals by imaging techniques is an essential component for scientific research and drug development. A major obstacle for in vivo imaging in awake animals is the need to hold the head stationary imaging apparatus during imaging. This...

Data Center Protection with Cyber-Physical Defenses

jdrayton@princeton.edu — Tue, 19 Feb 2013 11:45:32 GMT

Princeton Docket #12-2821-1 Researchers at Princeton University have developed a novel method for the protection of data stored in computer data centers, such as used by Google, Facebook, Amazon and other cloud computing providers. Physical attacks compromising the security of information technology infrastructures have been identified as one of the most overlooked aspects of data center security. The new method provides protection from physical attacks, such as an unauthorized break-in or insider entry, in which the perpetrator attempts to take the actual hard drive, or remov...

An Economically Competitive and Environmentally Friendly Process for Producing Synthetic Liquid Fuel from Coal, Biomass and Natural Gas

jdrayton@princeton.edu — Thu, 14 Feb 2013 11:52:38 GMT

Princeton Docket # 12-2791/2859-1 The challenges to reduce dependence on petroleum as energy sources, coupled with efforts to reduce greenhouse gas (GHG) emissions, are exigent problems faced by the US transportation sector. Researchers at Princeton University have developed a novel hybrid energy process that utilizes coal, biomass, and natural gas as feedstocks to produce any given volumetric capacity of gasoline, diesel, and kerosene. The process will produce synthesis gas (syngas) from each of the three feedstocks and subsequently convert that syngas to liquid fuels via...

Critical Drop Sizes for Manipulating Mist with Flexible Fiber Arrays

jdrayton@princeton.edu — Fri, 11 Jan 2013 14:08:08 GMT

Critical Drop Sizes for Manipulating Mist with Flexible Fiber Arrays Princeton Docket # 12-2738 Researchers at Princeton University have developed a method to predict an optimum drop size for retention of liquids in a fibrous material. The invention can be applied to choose designs used to create drops to spread on or retain in a given fibrous material for different purposes. Fibrous media are ubiquitous functional and versatile materials. Natural systems such as hair, feathers or adhesive pads, and engineered systems such as nano-textured surfaces or textil...

A Novel, Concentrated, High loading Nanoparticle-based Formulation of Progesterone for Emergency Traumatic Brain Injury, Princeton Docket # 12-2766

jdrayton@princeton.edu — Wed, 09 Jan 2013 08:49:26 GMT

A Novel, Concentrated, High loading Nanoparticle-based Formulation of Progesterone for Emergency Traumatic Brain Injury Princeton Docket # 12-2766-1 Unmet Need Progesterone is a water-insoluble steroidal hormone that is a promising therapeutic for treating traumatic brain injury (TBI). However, it is difficult to formulate the steroid for emergency administration due to its hydrophobicity, crystallinity, and poor bioavailability. In the literature, many different nanoparticulate formulations for progesterone have been described, but the highest concentration ...

Novel Chalcogenide Materials with Controllable Light Radiation Response Feature

jdrayton@princeton.edu — Tue, 08 Jan 2013 14:22:04 GMT

Novel Chalcogenide Materials with Controllable Light Radiation Response Feature Princeton Docket # 13-2839-1 Chalcogenide glass materials exhibit a variety of optical properties that make them desirable for near and mid-infrared communications and sensing applications. To address the pressing need for optical components fabricated from material that are compatible with the mid-infrared, Princeton University researchers have developed new techniques to obtain optically sensitive materials, with the feature of controllable response to light radiation. By doping silver nanoparticles into chalc...

Novel Mid-infrared Compatible Chalcogenide Structure Materials

jdrayton@princeton.edu — Tue, 08 Jan 2013 13:03:01 GMT

Novel Mid-infrared Compatible Chalcogenide Structure Materials Princeton Docket # 12-2828-1 The mid-infrared spectral region (3-12um) is a newcomer in the beam combining technology field gaining increasing attention. The emergence of commercially available semi-conductor lasers operating at room temperatures and at any wavelength in the mid-infrared range is rapidly shifting attention towards this part of the optical spectrum, creating a pressing need for optical components fabricated from materials that are compatible with the mid-infrared. To address this need, researchers at Princ...

Microfluidic Platform for the Dynamic Regulation of Mechanical Forces on Embryonic Organs

jdrayton@princeton.edu — Thu, 20 Dec 2012 13:01:36 GMT

Microfluidic Research Tool to regulate mechanical forces and properties in Branching Morphogenesis Princeton Docket # 13-2864-1 Researchers at Princeton University, Department of Chemical & Biological Engineering, have developed a microfluidic research tool to solve previously unanswered questions in the study of branching morphogenesis. Development of tubular branched organs such as the lung and kidney is dynamic, highly regulated, and dependent on mechanical forces, leading to an architecture that is critical for survival. Dysregulation during development of these organs lead...

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers

jdrayton@princeton.edu — Thu, 20 Dec 2012 08:18:06 GMT

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers Princeton Docket # 12-2785-1 Researchers in the Department of Chemical and Biological Engineering Princeton University have identified novel stapled peptides, which have been engineered to have high cytotoxic activity against several different cancer cell lines (unpublished data). In studying the effect of increasing the affininty of a BH3 peptide towards pro-survival proteins, five peptides have been identified, two of which are able to kill fo...

Broad Tunable Quantum Cascade Lasers with Multiple Strongly coupled Upper Laser States

jdrayton@princeton.edu — Tue, 11 Dec 2012 11:54:41 GMT

Princeton Docket # 10-2616 Broadly tunable QC lasers are ideal candidates for multi-analyte mid-infrared spectroscopy application. However, the maximum tuning range is usually limited by the inherently narrow gain spectrum of intersubband transitions. Princeton researchers have developed a ¿continuum-to-bound¿ QC laser, with two lower injector states rather than one, strongly coupled with the upper laser state at the operational electrical fields so that three transitions contribute to a broad gain spectrum. The strong coupling facilitates carrier transport fr...

Highly Power-Efficient Quantum Cascade Lasers with Ultra-Strong Coupling Injection

jdrayton@princeton.edu — Tue, 11 Dec 2012 11:54:40 GMT

Princeton Docket # 09-2561 The transport of electrons from the injector ground level to the upper laser level in the active region of a QC laser significantly influences the laser performance. The stronger the coupling between these two levels, the faster electrons can be transferred into the active region, the better is the performance of the device. In conventional QC laser designs, the injection barrier between the injector and the active region has the greatest thickness resulting in a tunnel coupling of approximately 4-8meV. Princeton r...

MedMon: A Novel Device for Monitoring Medical Device Security

jdrayton@princeton.edu — Fri, 07 Dec 2012 08:35:38 GMT

MedMon: A Novel Device for Monitoring Medical Device Security Princeton Docket # 12-2789-1 Rapid advances in personal healthcare systems based on implantable and wearable medical devices promise to greatly improve the quality of diagnosis and treatment for a range of medical conditions. However, the increasing programmability and wireless connectivity of medical devices also open up opportunities for malicious attackers. Unfortunately, implantable/wearable medical devices come with extreme size and power constraints, and unique usage models, making it infeasible to simply borrow conv...

A Measurement Process for the Determination of the Mixture Averaged Molecular Weight of Complex Mixtures

jdrayton@princeton.edu — Mon, 03 Dec 2012 13:36:27 GMT

A Novel Measurement Process for the Determination of the Mixture Averaged Molecular Weight of Complex Mixtures Princeton Docket # 12-2788-1 Researchers at Princeton University have developed a new process to determine the mixture averaged (or apparent) molecular weight of complex mixtures, specifically for liquid fuels, including automotive fuels, jet propulsion fuels, and rocket propellants. Mixture averaged molecular weight is a required quantity for the on-highway vehicle engine emission certification process. As calculated using current methods, the mixture average mole...

Iron Catalyzed Hydrogen Isotope Labeling of Aromatic Organic Compounds

jdrayton@princeton.edu — Fri, 16 Nov 2012 15:42:12 GMT

A novel isotope labeling method for labeling aromatic organic compounds Princeton Docket # 13-2854-1 Researchers at Princeton University have developed a novel isotope labeling method for labeling aromatic organic compounds with deuterium or tritium gas by use of proprietary iron-based catalysts. Introduction of radioactive isotopes into pharmaceutical compounds is important for nutritional and metabolic studies. Presently in pharmaceutical industry, the most widely used catalysts for tritium incorporation are iridium, platinum and palladium based. The high cost and high susceptibility to ...

A Scheme for Contention-Based Synchronization in FDMA Systems

jdrayton@princeton.edu — Fri, 16 Nov 2012 12:26:47 GMT

A Scheme for Contention-Based Synchronization in FDMA Systems Princeton Docket # 13-2835-1 Researchers at Princeton University and University of Pisa have developed a novel synchronization procedure for FDMA (frequency division multiple access) networks that minimizes power consumption and synchronization time. Current wireless standards (such as IEEE 802.16 and 3GPP LTE-A) rely on contention-based synchronization processes that utilize a highly energy inefficient and random-based means of addressing unsuccessful synchronizations during network association. By providing the network¿s nodes (m...

Piezoelectric Nanoribbons for Monitoring Cellular Deformation

jdrayton@princeton.edu — Fri, 16 Nov 2012 12:24:19 GMT

Piezoelectric Nanoribbons for Monitoring Cellular Deformation Princeton Docket # 13-2836-1 Researchers at Princeton University have developed a new process to make high performance flexible piezoelectric devices using PbZrxTi1-xO3 (PZT) nanoribbons. These devices have outstanding biointerface features with cells and tissues. The devices can be employed to sense cellular deformationsand demonstrate biocompatibility and high sensitivity for sensing cellular voltage-induce deformation. Currently, Atomic force microscopes (AFM) are employed to study the voltage-induced mechanical deflectio...

Two Novel X-ray Optical Schemes for Spectroscopy with Fast Time Resolution and Two-dimensional Imaging with High Magnification

jdrayton@princeton.edu — Wed, 14 Nov 2012 13:30:58 GMT

A Novel X-ray Optical Scheme for Spectroscopy with Fast Time Resolution and High Spectral Resolution Simultaneously Princeton Docket # 12-2779-1 Researchers at the Princeton Plasma Physics Laboratory at Princeton University have developed a novel x-ray optical scheme for spectroscopy with fast time and high spectral resolution. The technology makes use of one convex and one concave spherically bent crystal to image the radiation emitted from high-density, laser-produced plasmas. Significantly, this scheme provides simultaneously high time resolution as well as high spectral resolution...

Smart Stat - An integrated optogenetic protein induction system for industrial protein and drug production

jdrayton@princeton.edu — Tue, 16 Oct 2012 08:59:38 GMT

Smart Stat - An integrated optogenetic protein induction system for industrial protein and drug production Princeton Docket # 13-2838 "Smart Stat" is an integrated system which allows for real-timelight-based control of gene expression and subsequent protein production. An exogenous, highly controllable optogenetic induction system is integrated with a chemostat and robotically controlled microfluidic sampling system which allows for automated real-time imaging of cells from the steady-state chemostat culture. Quantification of protein concentration from t...

Diagnosis of Periodontal Status Using Protein Biomarkers Within Gingival Crevicular Fluid

jdrayton@princeton.edu — Mon, 24 Sep 2012 13:15:04 GMT

Non-invasive and Accurate Diagnosis of Periodontal Status Using Gingival Crevicular Fluid Biomarkers Princeton Docket # 12-2825 Researchers at Princeton University have developed a novel methodology for the optimal selection of biomarker proteins to diagnose the periodontal status of a patient using gingival crevicular fluid (GCF) samples. A mixed-integer linear optimization model has been developed and trained on 55 GCF samples from a mixture of periodontally healthy and chronic periodontitis patients, and a high degree of accuracy has been established. The method was the...

Research Tool for use in Drug and Vaccine Development to Investigate the Immune System in Response to Drug Intervention or Disease

jdrayton@princeton.edu — Thu, 20 Sep 2012 05:21:00 GMT

Research Tool for use in Drug and Vaccine Development to Investigate the Immune System in Response to Drug Intervention or Disease Princeton Docket # 12-2831 The invention is a novel computational procedure for assessing the immune status of a subject by examining sequences from T Cells of a subject. More specifically presented in this technology is a method for determining the statistical properties of the cellular machinery responsible for creating genetic diversity in the population of immune system T-cells in a human individual. The specific T-cell sequences in an ind...

Novel Design Modifications to Microfluidic Microscopes Enabling Full 3D Profiling

jdrayton@princeton.edu — Thu, 20 Sep 2012 05:20:59 GMT

Princeton Dockets # 12-2746, 12-2747, & 12-2748 Researchers at Princeton University have developed novel modifications to microfluidic microscope (MFM) devices. These new features will allow full three-dimensional (3D) profiling of objects, while retaining the simplicity and high throughput of traditional MFMs. Microfluidic Microscopy is a relatively new imaging technique based on guiding samples under the window of observation by flowing them in a microfluidic channel. They include both conventional microscopes (e.g. objectives) with modified slide s...

C3aR as Putative Target for Inflammation

jdrayton@princeton.edu — Wed, 15 Aug 2012 08:49:40 GMT

Novel C3aR agonists and antagonists for inhibiting pro-inflammatory activities of the human complement system targeting C3aR Princeton Docket # 12-2813 Novel agonists to C3aR have been designed using a de novo design framework. The best predicted peptides were experimentally validated using a rat basophilic leukemia cell degranulation assay and a monocytic cell calcium flux assay. Of the peptides tested using a degranulation assay in C3aR-transfected rat basophilic leukemia cells, two were prominent agonists (EC50 values in the nanomolar range) and two others were partial agon...

Novel Alloying Elements for Ni Cermet Anodes in Solid Oxide Fuel Cells-Improved Thermal Stability

jdrayton@princeton.edu — Fri, 22 Jun 2012 08:46:29 GMT

Princeton Docket # 12-2824 With high electrical efficiency, long-term stability, fuel flexibility, low emissions, and relatively low cost, solid oxide fuel cells (SOFCs) hold great potential for widescale deployment of fuel cell technology. The anodes of most solid oxide fuel cells (SOFCs) are made of nickel/yttria-stabilized zirconia composites (Ni cermets). Performance degradation of SOFCs with time, which is partially due to the adhesion failure of the interface between Ni and tetragonal/cubic zirconia, has greatly limited large-scale application of this technology. Using fir...

Feedback Control of Azimuthal Oscillations in Hall Thrusters: Enhanced Thruster Efficiency and Performance

jdrayton@princeton.edu — Thu, 14 Jun 2012 14:09:48 GMT

Princeton Docket # 12-2808 Researchers at Princeton Plasma Physics Laboratory have developed a novel method to achieve feedback control of low-frequency azimuthal waves (rotating spoke oscillation) in the ExB discharge of a Hall thruster. This technology will enhance thruster efficiency and performance. The Hall thruster is a plasma-based propulsion system for satellites and in the future, space vehicles. The field traps electrons in azimuthal ExB orbits inside the thruster channel, neutralizing the ion space charge and allowing the Hall thruster to produce a ...

Engineered Cys2His2 Zinc Finger Library for Efficient non -G Rich Target Selections

jdrayton@princeton.edu — Tue, 12 Jun 2012 12:04:19 GMT

Engineered Cys2His2 zinc fingers for efficient non-G rich Target selections Princeton Docket # 12-2803 Researchers in the Lewis-Sigler Institute for Integrative Genomics, Princeton University have developed a novel zinc finger profile library, which provides improvements to and expands upon the existence of known, artificial zinc fingers. Applications · Use as artificial transcription factors for a given target within a genome of interest...

Methods for Discovering RNA Structural Regulatory Elements and Affecting Their In Vivo Function

jdrayton@princeton.edu — Tue, 22 May 2012 11:28:53 GMT

TEISER (Tool for Eliciting Informative structural elements in RNA) - A Novel Computational Algorithm for Systemically Discovering RNA Structural Regulatory Elements in Research and Drug Discovery Princeton Docket # 12-2796-A Researchers in the Molecular Biology Department, Princeton University, have developed TEISER (Tool for Eliciting Informative structural elements in RNA), a novel computer algorithm for systemic discovery of structural elements governing stability of mammalian mRNAs. The algorithm is based on context-free grammars and mutual information ...

High-resolution and Low-Cost Flow Scanning Tomography for 3D Imaging

jdrayton@princeton.edu — Thu, 03 May 2012 08:45:03 GMT

Princeton Docket # 12-2798 Tomography is a method for three-dimensional imaging by sectioning, through the use of penetrating waves. Modern variations of tomography involve gathering projection data from multiple directions and using a computer to numerically reconstruct the final image. Tomography has been widely applied for medical imaging, industrial imaging, scientific research, and educational purposes. Tomography requires the use of multiple views, as the internal structure of objects can only be revealed by observations from different perspective...

A Simple and Highly Effective Method to Control Interfacial Instability by Leveraging Flow Geometry

jdrayton@princeton.edu — Wed, 02 May 2012 07:53:12 GMT

Princeton Docket # 12-2814 Researchers at Princeton University have developed a simple, easily implementable, highly effective, and accurate solution to control fluid interfacial instabilities. The researchers discovered that the simplest heterogeneity in the flow passage can lead to fundamentally different displacement behaviors. This finding can be leveraged to either inhibit or trigger an instability and, hence, to devise a strategy to manipulate instabilities in fluid-fluid systems. The control setting identified has a wide spectrum of applications ranging from small-scale tec...

MiRNAs as Novel Therapeutics and Non-invasive Biomarkers for Bone Metastasis

jdrayton@princeton.edu — Fri, 27 Apr 2012 09:00:35 GMT

Princeton Docket # 12-2807 Researchers in the Molecular Biology Department at Princeton University have discovered a group of miRNAs as novel therapeutics for bone metastasis. Through a series of in vitro and in vivo experiments, five distinctive miRNAs have been identified as inhibitors of osteoclast differentiation. Further, systemic treatment with the miRNAs in mice xenografted with highly metastatic breast cancer cells resulted in a remarkable reduction in tumor burden and bone lesion area, uncovering the potential for novel miRNA-based therapeutics in bone metastasis...

A Target and Screening System for the Identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseaes

jdrayton@princeton.edu — Wed, 25 Apr 2012 08:18:06 GMT

A target and screening system for the identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseases Docket # 12-2771 Researchers in the molecular biology department at Princeton University, together with researchers in the department of microbiology and immunology, School of Medicine, University of Nevada, Reno have developed a unique monocycle screening system which will allow for the large scale monocyte culture for biochemical studies or high throughput screening for therapeutics. As a particular example this system has ...

Multimedia Web Search Based on a Novel Similarity Search System

jdrayton@princeton.edu — Wed, 18 Apr 2012 14:22:24 GMT

Princeton Docket # 05-2158 To date, there is no practical similarity search engine for general-purpose high-dimensional data and there is no index engine for similarity search. Current search engines such as the Google search engine perform exact searches on text documents and text annotations of non-text data. Researchers at Princeton University have developed a content-addressable and ¿searchable storage system for managing and exploring massive amounts of feature-rich data such as images, audio or scientific data. Rather than using words to s...

Sensing Sheet for High-Resolution Structural Health Monitoring over Large Civil Engineering Structures

jdrayton@princeton.edu — Wed, 11 Apr 2012 14:18:45 GMT

Princeton Docket # 12-2744 Civil infrastructure in the U.S. is aging and has been identified as an area of critical need. Many bridges of great importance are approaching the end of their life span. It is necessary to determine and monitor their structural health in order to mitigate risks, prevent disasters, and plan maintenance activities in an optimized manner. The need for reliable, robust, and low-cost Structural Health Monitoring (SHM) is thus rapidly increasing. In spite of its great potential, SHM is not applied in a widespread or systematic mann...

Inexpensive and Efficient Materials for Solar Energy Conversion Devices

jdrayton@princeton.edu — Tue, 27 Mar 2012 11:27:08 GMT

Princeton Docket # 12-2790 Solar energy conversion devices include photovoltaics, photoelectrochemical cells and photocatalysts, which convert the energy of sunlight into electricity and/or produce fuels from carbon dioxide and water. Wide-scale implementation of these devices requires the development of less expensive materials with highly specific electronic properties to achieve useful efficiencies. Using first-principles quantum mechanics calculations, researchers at Princeton University have identified modified cuprous oxide materials for the next generation of...

Novel Catalysts for Asymmetric Olefin Hydrogenation: Low Cost, Low Toxicity, High Modularity

jdrayton@princeton.edu — Mon, 26 Mar 2012 08:11:21 GMT

Princeton Docket # 12-2801 Catalytic asymmetric hydrogenation reactions are important to prepare single enantiomer drugs, agrochemicals and fragrances. Present technologies for such reactions involve catalysts based on iridium, rhodium, platinum, and ruthenium. These precious metals are expensive, toxic, have fluctuations in supply and pose environmental concerns. Researchers are Princeton University have developed a novel route towards synthesizing a family of cobalt phosphine dialkyl compounds that are versatile catalysts for asymmetric olefin hyd...

Economical, Practical and High-Performance Photovoltaics by Incorporation of Wrinkles and Folds

jdrayton@princeton.edu — Mon, 19 Mar 2012 08:29:35 GMT

Princeton Docket # 11-2701 Optical manipulation of light has become an increasingly popular strategy to enhance light harvesting efficiencies in opto-electronic devices. Despite recent advances in nano-scale patterning techniques that have enabled the creation of discrete metallic building blocks or continuous metallic films having nano-hole arrays, the necessity to precisely engineer and accurately place such objects at pre-specified spacings and at appropriate interfaces over large areas has precluded the practical adoption of this strategy to enhance light harvesting effici...

Highly Sensitive Trace-Gas Sensing Method Based on Laser Spectroscopic Sensing of Anomalous Molecular/Atomic Dispersion

jdrayton@princeton.edu — Fri, 09 Mar 2012 07:09:58 GMT

Princeton Docket # 10-2584-1 Researchers from Princeton University and the STFC Rutherford Appleton Laboratory (UK) have developed a novel method of high sensitivity molecular detection based on detection of refractive index changes around the absorption line. This method employs heterodyne interferometric measurement with a frequency chirped laser source and offers high enhancement of the weak dispersion signal, which enables sensitive molecular quantification. It has been shown experimentally that this method is almost immune to laser power variatio...

Novel Methods for Chalcogenide Waveguide Fabrication on Curved Substrates

jdrayton@princeton.edu — Fri, 02 Mar 2012 06:56:59 GMT

Princeton Docket # 11-2657 Charcogenide glass materials exhibit a variety of optical properties that make them desirable for near- and mid-infrared communications and sensing applications. However, processing limitations for these photorefractive materials have made the direct integration of waveguides with sources or detectors challenging. Present methods of waveguide fabrication, including fiber drawing, direct write, and chemical etch or dry etch, can only reliably produce waveguide on flat substrates. &...

Inexpensive, Efficient, and Robust Materials for Solar Energy Conversion Devices

jdrayton@princeton.edu — Tue, 21 Feb 2012 10:32:02 GMT

Princeton Docket # 12-2782 Solar energy conversion devices include photovoltaics, photoelectrochemical cells and photocatalysts, which convert the energy of sunlight into electricity and/or produce fuels from carbon dioxide and water. Wide-scale implementation of these devices requires the development of less expensive materials with highly specific electronic properties to achieve useful efficiencies. The current materials design strategy aims to tune properties of relatively inexpensive transition metal oxides to increase sunlight absorption while preserving potential red...

Novel Photonic Solids for Trapping and Manipulating light for Use in Optical Applications

jdrayton@princeton.edu — Tue, 21 Feb 2012 10:32:00 GMT

Photonic solids are materials used to control the flow of light in optical applications, analogous to semiconductors in electronic applications. Also referred to as photonic band gap materials, they typically consist of a latticework composed of two interpenetrating substances with different indices of refraction (e.g., silicon and air), arranged so that the index of refraction varies on a length scale associated with the wavelength of the radiation to be controlled. For certain arrangements of materials, the solid has a complete photonic band gap, a range of frequencies for which electromag...

A Simple Microfluidic Device for Flow Control

jdrayton@princeton.edu — Fri, 10 Feb 2012 14:04:00 GMT

Princeton Docket # 12-2739 Researchers at Princeton University have developed a novel device for manipulating liquid flow in micro channels and chambers. This device is simple and robust, and does not require a power source. Controlling and directing liquid flow within a microfluidic device is important in a variety of applications ranging from microfluidic diagnosis and analysis to self-healing devices. Current systems employ external pumps and/or valves, pressure or vacuum methods, electric signals or drivers, or surface tension methodology to move f...

Smart Scaffolds for Tissue Repair and Regenerative Medicine

jdrayton@princeton.edu — Fri, 10 Feb 2012 14:03:52 GMT

Smart Scaffolds for Tissue Repair and Regenerative Medicine Princeton Docket # 12-2742 A major challenge in biomedical research with application to regenerative medicine is to cause cells to assemble into particular orientations or alignments on a scaffold device in order to generate tissues with the required cellular organization and mechanical properties. As alignment is key to tissue regeneration, this novel method rapidly generates an aligned monolayer of confluent cells that assemble a "natural" extracellular matrix (ECM). As the resulting ECM is a natural scaffold, it can...

Long Optical Path Lengths by A Compact and Robust Chaotic Optical Multi-Pass Cavity

jdrayton@princeton.edu — Tue, 07 Feb 2012 07:35:31 GMT

Princeton Docket # 08-2414 Typical optical gas sensors utilize multipass cells to probe molecular species by absorption spectroscopy. Existing multipass cells are usually costly, large, and lack robustness, which limits their use for portable systems. Princeton researchers have designed and fabricated a highly compact and robust optical cavity, which is composed of essentially a single reflective surface formed by two quadrupolar-shaped half-shells that are securely attached to each other. The cavity can effectively focus the beam when light bounces rep...

Novel Compounds for Treating Cholera and Other Infections: Potent Agonists of the Quorum Sensing Circuit

jdrayton@princeton.edu — Tue, 31 Jan 2012 13:48:22 GMT

Princeton Dockets # 08-2418, 12-2775 & 12-2776 Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening disease. It is estimated that cholera affects 3-5 million people worldwide, and causes 100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and cotrimoxazole have been used to shorten the course of the disease and reduce the severity of the symptoms. However, with antibiotic resistance on the rise, novel antimicrobials with different mechanisms of action are in urgent need. Researchers at Princet...

Microfluidic Ultralow Interfacial Tensiometry: Accurate and Low Cost

jdrayton@princeton.edu — Mon, 30 Jan 2012 10:39:32 GMT

Microfluidic Ultralow Interfacial Tensiometry: Accurate and Low Cost Princeton Docket # 12-2778 Researchers at Princeton University have developed a novel technique to measure ultralow interfacial tensions using paramagnetic spheres in a microfluidic co-flow device. The resulting tensiometry device is accurate, low cost, compact in size, and easy to integrate. Fluid systems that have ultralow interfacial tensions appear in a range of different applications, including uses in oil and food industries. However, quantifying ultralow interfacial tensions practically and accur...

New Dopants for Iron (II) Oxide-Based Solar Energy Conversion Devices: Enhanced Conductivity

jdrayton@princeton.edu — Tue, 10 Jan 2012 14:49:10 GMT

Princeton Docket # 12-2774 Solar energy conversion devices include photovoltaics, photoelectrochemical cells and photocatalysts, which convert the energy of sunlight into electricity and produce fuels from carbon dioxide and water. Different materials for making the solar energy conversion devices exhibit different energy conversion efficiencies and entail different costs. Currently, the most prevalent semiconductor material used in the solar industry is (poly)crystalline silicon for photovoltaics, which requires an expensive purification process to obtain pure and defect-...

New Iron (II) Oxide Alloys for Solar Energy Conversion Devices: Reduced Cost and Enhanced Efficiency

jdrayton@princeton.edu — Tue, 10 Jan 2012 14:49:09 GMT

Princeton Docket # 12-2773 Solar energy conversion devices include photovoltaics, photoelectrochemical cells and photocatalysts, which convert the energy of sunlight into electricity and produce fuels from carbon dioxide and water. Solar energy conversion devices exhibit different energy conversion efficiencies and costs. Currently, the most prevalent semiconductor material used in the solar industry is (poly)crystalline silicon for photovoltaics, which requires an expensive purification process to obtain a pure and defect-free material. First row transition metal oxides are...

Reducing Overpotentials in Hematite Photoanode Photoelectrochemical Cells by Doping

jdrayton@princeton.edu — Mon, 19 Dec 2011 13:42:34 GMT

Manganese, Cobalt, and Nickel as Effective Additives for Hematite-Based Photoanodes Princeton Docket # 12-2755 Photoelectrochemical cells (PECs) generate fuel from sunlight-driven electrochemical reactions. It is highly desirable to find cheap and effective means to generate hydrogen via water splitting reactions. Among the many potential candidates for photoanode materials for this process, hematite (a-Fe2O3, one of the main components of rust) stands out as being low-cost, abundant, non-toxic, and it has a nearly optimal band gap for solar energy absorption. Hematite photoanodes...

Improved Silicon Solar Cell Fabrication

jdrayton@princeton.edu — Mon, 12 Dec 2011 11:17:55 GMT

Princeton Docket No. 09-2565/2664-1 Researchers at Princeton have developed a new method of fabrication of silicon solar cells that enhances efficiency. Princeton is currently seeking an industrial partner to commercialize this technology. Minority carrier recombination at silicon surfaces and metal contacts greatly reduces the efficiency of photovoltaic devices. Princeton has demonstrated the use of an organic compound and method that provides a novel way to passivate the defects at silicon surfaces...

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules

jdrayton@princeton.edu — Wed, 07 Dec 2011 08:44:48 GMT

Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl chlorides also find widespread use as intermediates in organic synthesis, as in cross coupling reactions. Based on research and expertise in metalloporphyrin chemistry, researchers in the Department of Chemistry, Princeton ...

Programmed Autoregulation of Stem Cell Differentiation into Pancreatic Beta cell: Potential Treatment for Diabetes

jdrayton@princeton.edu — Mon, 05 Dec 2011 13:10:08 GMT

Princeton Docket # 07-2347 Researchers in Electrical Engineering and Molecular Biology, Princeton University have developed new levels of controlled differentiation in embryonic stem cells that are well-beyond existing technologies. The proposed approach will lead to new opportunities and strategies in many different biomedical therapies, such as Diabetes Mellitus. Princeton is currently seeking commercial partners for the further development and commercialization of this opportunity. The current standard treatment for diabetes is to maintain insulin levels by mo...

Inducing apoptosis in quiescent cells, a potential new therapeutic strategy for chemotherapy and the treatment of fibrotic disease

jdrayton@princeton.edu — Mon, 05 Dec 2011 10:32:48 GMT

Princeton Docket # 11-2633 The ability to selectively kill quiescent cells could be a powerful tool in medicine. In particular, the ability to kill the quiescent tumor stem cells could be an important addition to our chemotherapeutic repertoire. A better understanding of the transition between quiescent and activated cellular states of fibroblasts may also suggest new strategies to treat fibrotic disease. Using metabolomics technology, researchers in the department of Molecular Biology at Princeton University have discovered that the pentose phosphate pathway is active in cultured...

Incorporation of Cisplatin, Carboplatin and Oxalplatin in to a Trinuclear Iron-Platinum Intervalent Charge Transfer Complex: Options for the photochemical Delivery of Cisplatin to Targeted Sites

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:51 GMT

Princeton University Invention # 08-2484 Cisplatin is a leading chemotherapy agent; however its effectiveness is limited by its severe side effects. Researchers at Princeton University and the University of Medicine and Dentistry New Jersey, Department of Chemistry and Department of Pathology and Laboratory Medicine, respectively have synthesized photoreducible complexes incorporating cisplatin. These complexes contain an intervalent charge transfer band that when irradiated with visible light undergo a charge transfer reaction forming cisplatin. These compl...

Resistant-Prone Small Molecule Anti-Bacterial Antagonists and Targets for Anti-Bacterial Drug Development

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:50 GMT

Princeton Docket # 08-2467 & 08-2486 Researchers at Princeton University, Department of Molecular Biology, have identified and synthesized small molecule antagonists that could serve as broad spectrum lead compounds for the disruption of quorum sensing in pathogenic Gram-negative bacteria. In proof of principle experiments, potent antagonist molecules have been developed that interfere with quorum sensing in several Gram-negative bacteria. It has been demonstrated that the administration of these quorum-sensing antagonist molecules to an animal, protect it from quorum-...

Compstatin Variants as therapeutic leads for Autoimmune and Inflammatory Disease

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:49 GMT

Princeton University Invention # 09-2488 The present invention relates to a series of novel analogues to compstatin. Based on experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new analogues show greater binding affinity compared to native compstatin and are therefore potentially more potent drug candidates for diseases related to improper complement activation. Low nanomolar binding affinities similar to alternative analogues described in the literature have been achieved and, based upon testing modifications with non-natural amino acids, even grea...

EGFR Inhibitors as Therapeutic Agents for Breast Cancer Bone Metastasis

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:48 GMT

Princeton University Invention # 09-2509 The involvement of the EGFR signaling pathway in bone metastasis has been implicated by a number of studies. However, the therapeutic significance by targeting EGFR signaling in the tumor-stroma interface has not been evaluated. Researchers in the Molecular Biology Department at Princeton University have used a preclinical model of breast cancer bone metastasis to demonstrate that breast cancer cells resistant to the cytotox...

Template Guided DNA

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:47 GMT

Princeton University Invention # 09-2521 Researchers in Ecology and Evolutionary Biology and Molecular Biology, Princeton University, have described a new process based on the natural biological mechanism of RNA-guided DNA recombination as discovered and reported in their recent publication, Nowacki et al. Nature 2008 January ¹. The process describes a general approach to target or program specific DNA or genome rearrangements in a wide range of cells, based just on knowledge of the desired rearrangement product or DNA sequence. This process was i...

VCAM1 and VLA4 as Therapeutic Targets for Anti-Tumor and Anti Metastatic Therapy

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:47 GMT

Princeton University Invention # 09-2550 In breast cancer patients, disseminated tumor cells from the primary site can remain in a dormant state in the secondary organ for a long period before starting to grow into life-threatening metastasis. However, the molecular understanding of this process is still very limited. Researchers in Molecular Biology, Princeton University have demonstrated that Vascular Cell Adhesion Molecule-1 (VCAM1) is essential for the conversion from dormancy to macrometastasis in a xenograft mouse model of breast cancer bone metastasis. A weakly ...

miR-200 Family and miR194/192 Cluster of miRNAs in Cancer Progression and Metastasis

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:46 GMT

Princeton University Invention # 09-2551 Over 90% of cancer-related deaths are due to the metastatic spread of primary tumor cells to distant vital organs. Epithelial-mesenchymal transition (EMT) is a key cellular process through which tumor cells gain the ability to migrate and invade into their surrounding tissue. The reverse process, (MET), has also been postulated to be important for tumor cells to regain their epithelial phenotype once they reach the target organ and to successfully produce macroscopic lesions. MicroRNAs (miRNAs) have been increasingly recognized t...

Protected nanoparticle formulations of diazeniumdiolate class of nitric oxide prodrugs

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:45 GMT

Princeton University Invention # 10-2589 Researchers at Princeton University, Department of Chemical Engineering together with researchers at the National Institute of Cancer have developed protected nanoparticle formulations of the diazeniumdiolate class of anti-cancer lead compounds. Examples include PABA/NO O2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate and double-JS-K(1,5-bis{[1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolato]-O2)-2,4-dinitrobenzene), through their incorporation into polymer-protected nanopa...

ELECTRONIC SENSOR FOR DETECTION OF PATHOGENIC BACTERIA

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:44 GMT

Princeton Docket 10-2626/2696-1 Researchers at Princeton have developed a new design of electronic sensor for the detection of pathogenic bacteria. Princeton is seeking an industrial partner to commercialize this technology. Current methods for detecting pathogenic bacteria include enzyme-linked immunoassay (ELISA), and polymerase chain reaction (PCR). ELISA exploits antibodies as molecular recognition elements due to their highly specific targeting of antigenic sites. However, antibodies lack the st...

Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:43 GMT

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibition action against E. coli and the pathogenic Salmonella strain S. Newport. Few new classes of antibiotics have been discovered in the past decades and the emergence of multi-drug resistant organisms demands new antib...

Detection and Destruction of Cancer Cells Using Programmed Genetic Vectors

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:42 GMT

Princeton University Invention # 08-2468 Current cancer treatments (e.g. chemotherapy or radiation therapy) utilize highly non-specific approaches to killing cancerous cells. Such methods are not able to specifically target a particular type of cancer cell and, although these treatments kill cancer cells, they also inflict a great deal of collateral damage on healthy cells. In addition, multiple treatments are typically necessary in order to place a patient in `remission¿. The harmful side effects from repeated assaults on the body by deadly chemicals or radia...

Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Protein EGL-1

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:41 GMT

Apoptosis or programmed cell death is an essential process in the development and homeostasis of all multi-cellular organisms such as humans. Suppression of programmed cell death is a contributing reason for a range of human diseases such as cancer. Thus finding a strategy to specifically down-regulate the functions of Bcl-2 and Bcl-xL is important to potential anti-cancer therapies. Past effort in screening and designing Bcl-2/Bcl-xL inhibitors has been rather primitive, in part...

New Simple Tools, NeFRECs, for Large Scale Screens Using Small Molecules and Genomic Libraries in Stem Cell Biology and Nuclear Reprogramming

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:40 GMT

Princeton University Invention # 05-2180 Molecular mechanisms regulating the identity of stem cells and their balance of self-renewal and differentiation are critical for proper tissue development of every organism and the development of regenerative cell therapies. Embryonic stem cell-based therapies bear some potential but are very controversial. Understanding the factors required for nuclear reprogramming might help to develop personalized stem cell therapies thereby circumventing some of the logistical and societal concerns surrounding somatic-cell nuclear transfer in...

Correction of Presbyopia with Ultrashort Pulse Laser (Crystalline Lens Surgery)

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:39 GMT

Princeton University Invention # 05-2211 Presbyopia is a natural age-related process that affects everyone from the age of 45 on, regardless of whether or not they have always had normal vision or have suffered from myopia, hyperopia or astigmatism. Presbyopia is the increasing inability to maintain near objects in focus. People with presbyopia have to hold reading materials at arms¿ length to be able to focus on the image. Currently there is no surgical correction for presbyopia available that directly restores the accommodative ability of the native cry...

Genome-Wide mapping of Polymorphisms at Nucleotide Resolution with a Single DNA Array

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:38 GMT

Princeton Invention # 06-2269 A central challenge of genomics is to detect, simply and inexpensively, any and all differences in sequence among the genomes of individual members of a species. Researchers at the Lewis-Sigler Institute for Integrative Genomics, Princeton University , have devised a system using high-density Affymetrix yeast tiling microarrays that detects single-nucleotide differences between yeast genomes and maps them to within a few nucleotides on a reference sequence, without any prior knowledge of their location. They have developed an ...

METHOD FOR GENETIC ANALYSIS OF ALTERNATIVE SPLICING

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:37 GMT

Researchers at Princeton University have developed methods useful in genetic high-throughput screens (HTS) of alternative splice variants. More specifically, the developed technology can be applied for massive functional identification of splice variants whose misexpression can promote cancerous cell transformation or induce stem cell differentiation toward specific lineages. Princeton is currently seeking industrial collaborators to commercialize this technology. More than 70% of human genes underg...

Novel Metalloporphyrins and Related Metal Complexes for the Treatment of Oxidative Stress and Diseases with Oxidative Components

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:37 GMT

Princeton Invention # 99-1608 &n...

Spherical Mount for Head Fixed Behavior

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:36 GMT

Princeton University Invention # 07-2335 Researchers in the Department of Neuroscience, Princeton University have developed a unique apparatus which allows for head fixed experiments without using anesthesia and without inducing stress to the animal. The apparatus allows for mice or rats to run and behave freely while fixed in the laboratory. The animal runs on a styrofoam ball in a nearly unhindered way, while at the same time the head is fixed. This device has use in behavioral neuroscience research where there is a great need to allow the animal to behave freely whil...

A Cell Line and Mouse Model for Studying Pathological TGFß Signaling during Cancer Progression and Metastasis in vivo

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:34 GMT

Princeton Invention # 07-2351 Cancer metastasis requires the intricate interactions between cancer cells and the host tissue microenvironment. Although TGFb signaling pathway has been implicated in breast cancer metastasis to bone and other target organs, the temporal-spatial requirement and the in vivo dynamics of TGFb signaling in organ-specific metastasis has not been vigorously investigated. Here, we engineered a MDA-MB-231 human breast cancer cell line in which endogenous Smad4 expression is eliminated by ...

Glycosylated Steroid Derivatives for Transport Across Biological Membranes

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:33 GMT

This technology uses novel glycosylated steroid derivatives to facilitate the transport of molecules of a second compound across biological membranes. The facilitation is achieved by combining the derivatives with the molecules of interest, either as a conjugate comprising the derivative covalently linked directly or indirectly with the molecule of interest or as an admixture comprising the two main components. In this manner, the molecule of interest, especially those of a therapeutic si gnificance, can better exhibit its activity, whether of a biological, physical or chemical...

Imaging and Recording From Head Fixed Rodents on a Spherical Treadmill

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:31 GMT

Princeton University Invention # 07-2353 Researchers in the Department of Neuroscience, Princeton University have developed a unique apparatus which allows for micron-scale optical recording, imaging and stimulation of neural activity of awake and behaving rodents while they are head fixed. For several important questions in neuroscience, it is important to relate animal behavior to cellular processes. This is difficult because the best tools to measure and stimulate neural processes require single cell resoluti...

Cold Sterilization of Plastic Containers

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:30 GMT

The sterilization of plastic containers for beverage, food and pharmaceutical products is a significant cost to the associated industries. Currently, plastic containers are sterilized using heat, which necessitates the use of polymers that can withstand the high temperature without degrading or deforming. These heat resistant polymers have a cost of up to 1.7 times that of comparable lower temperature products. As such, any improvements in the sterilization process will have a large econ omic impact. Researchers at Princeton Plasma Physics Laboratory have developed a new p...

microRNAs for Modulating Herpes Virus Gene Expression

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:29 GMT

Princeton University Invention # 07-2381 Researchers in the Molecular Biology department at Princeton University and the Simons Center for Systems Biology at the Institute for Advanced Study have developed an improved algorithm for the prediction of mRNAs that are targeted by known microRNAs. The algorithm was employed to identify the targets of cell-coded and virus-coded microRNAs in mRNAs encoded by herpesviruses. One of these predictions have been validated experimentally. These naturally occurring mi...

NEW USES OF THE Cre/Lox RECOMBINATION SYSTEM AND THE PSEUDORABIES VIRUS NEURAL CIRCUIT TRACING SYSTEM

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:28 GMT

Researchers at Princeton University have developed a novel method for tracing the neural circuits of the central nervous system (CNS). Princeton is currently seeking industrial collaborators to commercialize this technology. Traditionally, tracing the neural circuits of the CNS has been limited by the lack of a suitable method for trans-synaptic tracing. This new method has the capability of retrograde tracing of specific neural connections across multiple synapses. This is accomplished by using a recombinant alpha-herpesvirus (pseudorabies virus; PRV) which is dependent on a Cre-medi...

Metadherin: Therapeutic Target for Treating Primary and Metastatic Cancer and Combating Chemoresistance

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:27 GMT

Princeton Docket # 07-2399 Researchers in the Molecular Biology Department at Princeton University have identified a recurrent 8q22 genomic gain in poor-prognosis human breast cancers, which harbors the metastasis gene Metadherin (MTDH). Genomic gain of 8q22 elevates expression of MTDH, which is overexpressed in more than 40% of breast cancers and is associated with poor clinical outcomes. Further characterization of MTDH both in vitro and in vivo reveals its dual role in promoting metastatic seeding and enhancing chemoresistance. These findings establish MTDH ...

METHOD FOR MEASURING TRI-NUCLEOTIDE REPEAT EXPANSION

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:25 GMT

Researchers at Princeton University have developed a novel technique for the measurement of tri-nucleotide repeat expansion. Princeton is currently seeking industrial collaborators to commercialize this technology. An ever increasing number of human genetic diseases are attributable to the expansion of tri-nucleotide repeats (TNR's). For example, fragile X syndrome, the second leading cause of mental retardation, is due to the expansion of a CGG tract. Myotonic muscular dystrophy, the most common dys...

Method for Applying Two-Dimensional Electric Field Distribution in Micro-Electrophoretic Devices and Injecting Narrow Band of Samples

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:25 GMT

Researchers at Princeton University have developed three new methods for manipulation of DNA and other large macromolecules in microfluidic environments. The first method permits fractionation of DNA continuously on micro or nano-fabricated support materials. Current methods to fractionate larger (greater than 30kb) DNA molecules by size use pulsed gel electrophoresis and typically take several days to fractionate one set of samples. This new method uses micro or nano fabricated environments to accurately control the motion of the DNA molecules, ...

Method for Applying Two-Dimensional Electric Field Distributions in Micro-Electrophoretic Devices and Injecting Narrow Bands of Samples

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:24 GMT

NOVEL ASSAY FOR PANCREATIC PATHOLOGY --DETERMINATION OF CARBOXYPEPTIDASE A LEVELS IN HUMAN SERUM

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:23 GMT

Researchers at Princeton University have developed a novel assay for pancreatic pathology which is expected to be far superior to the conventional assay based on amylase. Princeton is seeking industrial collaborators to commercialize the technology. The technology is an improved procedure for measuring serum levels of Carboxypeptidase A. It is therefore a significantly more reliable assay of pancreatic pathology than the conventional assay for amylase since the pancreas is the only source of CPA in serum. Moreover, the method allows for the measuring of levels of...

INTEGRAL MEMBRANE GFP-FUSION PROTEIN

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:21 GMT

Researchers at Princeton University have developed a novel technique for the simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Princeton is currently seeking industrial collaborators to commercialize this technology. The green fluorescent protein (GFP) is currently used in assays as a marker to detect the subpopulation of transfected cells. However, there are certain technical limitations to the use of GFP in combination with other protocols such as c...

Continuous Fractionation of DNA Using Asymmetric Pulsed Field Electrophoresis on Micro/Nano-Fabricated Matrices

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:13 GMT

A Novel Method of Interfering with Iron Uptake by Mycobacterium Tuberculosis and Related Organisms

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:12 GMT

Princeton Invention # 04-2103 Researchers in the Chemistry Department at Princeton University have discovered a novel pathway which may allow for a new pharmacological approach to the control of tuberculosis. The rational discovery of drugs requires prior knowledge of metabolic pathways. Usually this involves identifying the function of certain enzymes in a metabolic pathway of interest and then finding inhibitors of those enzymes. In contrast, Princeton researchers have discovered a new mechanism by which myc...

Recombinant Adeno-Associated Viruses for use in Gene Therapy

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:10 GMT

Princeton University Invention # 90-0954 The technology as described in US patent # 5,753,500 relates to a method for producing substantially pure stocks of recombinant adeno-associated virus, free of the adeno-associated helper virus found associated with previously available recombinant AAV. These pure stocks can be used to introduce exogenous genetic sequences into cells, cell lines, or organisms. In the absence of the adeno-associated helper virus, the recombinant AAV will remain stably integrated into cellular DNA. Novel recombinant AAV vectors and adeno-a...

A method for measuring and modeling quantitative sequence-function relationships for possible applications in transcriptional misregulation, antibody optimization, and antigenic epitope development

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:04 GMT

Princeton University Invention # 10-2580 Researchers in the Physics and Molecular Biology Departments, Princeton University, have developed a method that uses a simple mutational assay and information theory to decipher the molecular mechanisms by which a biological sequence functions, either in vitro or in living cells. This technology was demonstrated as a powerful tool for studying transcriptional regulation, and may thus be useful for identifying therapeutic targets for a variety of diseases. The method is very general, though, and should be applicable to a wide variety of ...

Approaches to Influenza Vaccine Design and Vaccine Strain Selection

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:15:00 GMT

Princeton University Invention # 09-2507 Researchers in Ecology and Evolutionary Biology and Molecular Biology, Princeton University, have developed biophysically grounded conceptual approaches, which take into account antibody interference, to design influenza vaccines and anti-influenza virus therapies that may afford better protection against infection. Additionally, the Princeton researchers have developed quantitative approaches to improving the selection of suitable vaccine strains to be used in the development of flu vaccines. Influenza viruses cause regular epidemics...

Compositions and Methods for Regulating Intramembrane Proteases

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:59 GMT

Princeton University Invention # 07-2348 Intramembrane proteolysis is a widely conserved regulatory mechanism in species ranging from bacteria to humans. The first description of intramembrane proteolysis came from the investigation of cholesterol homeostasis, where the ER membrane-bound transcriptional factor SREBP must be cleaved by an integral-membrane protease, known as site-2 protease (S2P). This cleavage results in the release of the N-terminal domain of SREBP, which contains a DNA-binding domain and a transactivation domain. The N-terminal domain of SREBP re...

A High Throughput Screen for Molecules that Prevent the Alzheimer's Peptide Aß42 from Aggregating

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:58 GMT

Princeton Invention # 06-2246 Researchers in the Chemistry Department at Princeton University have developed a method for screening large libraries of small molecules to find those ¿hits¿ that block Aβ42 aggregation. The development of this high throughput screen is based on the finding that fusions of Aβ42 to green fluorescent protein ( GFP) prevent the folding and fluorescence of GFP, whereas mutations in Aβ42 that disrupt aggregation produce green fluorescent fusions. It has been demonstrated that the Aβ42-GFP fusi...

A G-Protein Receptor Based Biosensor for Detection and Identification of Chemicals

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:57 GMT

Princeton Invention # 05-2225 Researchers at Princeton University have developed a robust system for functional expression of heterologous G-protein coupled receptors (GPCRs) in the yeast Saccharomyces cerevisiae and have successfully applied this system to develop novel biosensors based on the concepts of combinatorial recognition. Their work has demonstrated the feasibility of modifying existing GPCR¿s to constitute an array of sensors that in sum have recognition far in excess of the number of detecto...

COMPOSITIONS AND METHODS FOR MODULATING LYSINE PRODUCTION

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:56 GMT

Princeton University Invention # 05-2191 L,L-diaminopimelic acid aminotransferase, a key enzyme in a new variant of the lysine biosynthesis pathway was discovered by researchers at Princeton University and Rutgers University. The gene for this enzyme was also identified and cloned from the experimental plant Arabidopsis thaliana by researchers at Rutgers. Homologs of the gene have been identified in the genomes of major crop plants, algae, cyanobacteria, archaea, and in pathogenic microorgan...

Simple, Economical Bioseparation Technique Using Self-Cleaving Thermally Responsive Fusion Tags

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:55 GMT

Princeton Invention # 05-2188 Researchers in the Chemical Engineering Department at Princeton University have developed a new economical method for the purification of recombinant proteins expressed in E. coli and other expression host cells. This method relies on a self-cleaving elastin-like polypeptide (ELP) fusion tag, which effectively eliminates the need for conventional affinity chromatography or proteolytic tag removal in the purification of arbitrary fusion protei...

Method of Screening compounds that Antagonize HAUSP

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:55 GMT

Princeton University Invention # 2174 Cancer is one of the most debilitating diseases affecting mankind. More than 600 thousand patients die of cancer in the United States. Oncogenesis is inhibited by the tumor suppressor genes and accelerated by oncogenes. p53 is one of the most important tumor suppressor proteins and is inactivated in nearly all cases of cancer. In approximately half of all cancer cases, p53 is inactivated by mutation; in the other half of all cancer cases, wild-type p53 is inactivated by accelerated degradation or mis-localizati...

Soluble, Functional Apoptotic Protease-Activating Factor-1 Fragments

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:54 GMT

Princeton University Invention # 05-2166 Apoptosis or programmed cell death is an essential process in the development and homeostasis of humans. Abnormal inhibition of apoptosis is a hallmark of cancer and autoimmune diseases, whereas excessive activation of cell death is implicated in neuro-degenerative disorders such as Alzheimer¿s disease. Apoptosis is executed by the enzymatic activity of a family of special proteases termed ¿caspases¿. Caspases are synthesized as inactive zymogens and must be proteolytic...

METHOD FOR ANALYSIS OF GENETIC INTERACTIONS

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:53 GMT

Researchers at Princeton University have developed methods useful in large-scale probing of interactions between genes and their products. More specifically, the new technology is useful for a systematic parallel analysis of genetic and protein-protein interactions on a genome-wide scale. For example, the developed technology can be applied for massive detection of gene combinations that promote generation of cancer or induce stem cell differentiation toward specific lineages. Princeton is currently seekin...

Engineered In Vivo Biosensors for Nuclear Hormone Receptor Ligands

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:52 GMT

Princeton University Invention # 04-2095 Researchers in the Chemical Engineering Department at Princeton University have developed a new type of biosensor using Escherichia coli that can report ligand binding to eukaryotic nuclear hormone receptors. This system has been optimized to report the presence of endocrine-active compounds through changes in growth rates of bacterial (Escherichia coli) cells. Similar assays have been constructed in yeast Saccharomyces cerevisiae, but this new bacterial system is simple, faster, and more cost efficient. &...

New Simple, Economical Bioseparation Technique Using Self-Purifying, Self-Cleaving Affinity Tags

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:51 GMT

Princeton Invention # 04-2076 Researchers at Princeton University have developed a new economical method for the purification of recombinant proteins expressed in E. coli. In this method, the host cells simultaneously produce both an affinity tagged product protein and an easily recovered granular affinity carrier. The self-cleaving capability of the affinity tag allows the simple recovery of a native target protein at reasonable yield and very low cost. This simple technique...

Targeted Dual Drug Delivery System for Non-Small Cell Lung Cancer and other diseases of the Lungs

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:50 GMT

Princeton Docket # 10-2608 Researchers in the Department of Chemical and Biological Engineering, Princeton University and in the Department of Pharmaceutics, Rutgers University have developed a targeted lung-specific delivery system which employs both passive and active targeting to intravenously deliver anti-cancer drugs to tumor cells as well as to reduce the occurrence of metastasis. The first layer of the delivery system is a gel microparticle (GMP) designed to take advantage of the venous lung filtration pathway and passively accumulate in the lungs after intravenou...

Multiplexed Shotgun Genotyping (MSG) - Genome Wide Genotyping at Low Cost and High Efficiency

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:48 GMT

Princeton Docket # 11-2635 Researchers in Ecology and Evolutionary Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University have developed a technology¿called Multiplexed Shotgun Genotyping (MSG)¿that provides genome-wide estimates of ancestry (genotypes) in a large number of individuals at low cost. MSG combines a novel approach to construct next generation sequencing libraries and includes a sophisticated statistical framework to assign ancestry and to identify recombination breakpoints. MSG is significantly more efficient than other existing technologie...

Quorum Sensing: Cell-to-Cell Communication of Pathogenic Bacteria

jdrayton@princeton.edu — Thu, 01 Dec 2011 18:14:47 GMT

Quorum Sensing is an essential form of intercellular communication used by many types of common bacteria, and many pathogenic bacteria use quorum sensing to attack and invade the human host. Quorum Sensing is used by bacteria to detect a critical cell number, which is the cell population required for pathogenic bacteria to release effective amounts of toxins that overcome host immune defenses. In a sparse pathogenic bacteria population, the early release of toxins would stimulate the human immune system to neutralize the bacteria. Pathogenic bacteria have deve...

Novel Therapeutics for Cancer Metastasis

jdrayton@princeton.edu — Thu, 01 Dec 2011 16:03:30 GMT

Princeton Docket # 11-2691-1 Using various in vitro and in vivo xenograft model systems and clinical samples, researchers in the department of molecular biology, Princeton University have validated a stage-specific functional role of the miR-200 family to tumor progression. Current studies suggest that the miR-200 family may hinder an early step of metastasis (invasion) but yet can promote metastatic colonization in a distant organ, a critical rate-limiting step in the multiple-step cascade of metastasis. These studies suggest that the miR-200 family may play a key role to allo...

FORMATION OF A SILICATE SPONGE ( L3 ) PHASE

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:48 GMT

Researchers at Princeton University have developed a novel technique for formation of a new random bicontinuous silicate mesomorph with advantageous pore structure and overall morphology. Princeton is currently seeking industrial collaborators to commercialize this technology. Most procedures for forming mesoporous silicates rely on the micelle-forming properties of a surfactant, typically at low concentration. The addition of an inorganic precursor, such as siloxane, leads to association and co-assembly into a liquid crystal precipitant. Subsequent polymerizatio...

METHOD FOR PREPARING CERAMIC ARTICLES AND NOVEL CERAMIC COMPOSITION

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:47 GMT

Researchers at Princeton University have developed novel a technique for the fabrication of ceramic articles as well as a new ceramic composition. Princeton is currently seeking industrial collaborators to commercialize this technology. Recently, solid freeform fabrication techniques have been developed for producing three-dimensional articles without the need for molds, dies, or other tooling. Prototypes of these articles are c...

Electrohydrodynamic Patterning of Colloidal Crystals

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:46 GMT

Researchers at Princeton University have developed a new method of producing materials with micron and submicron patterns. Such materials are important in numerous applications, including photonic materials, high-density magnetic data storage devices, microchip reactors, and biosensors. Princeton is currently seeking industrial collaborators to commercialize this technology. The Princeton method combines the well-known photochemical sensitivity of semiconductors with electrical-field-induced assembly to create ordered arrays of colloidal particles with tunable...

New Process for Diamond Wire Saw Cutting of Complex Metal and Concrete Structures

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:45 GMT

Researchers at Princeton University have developed a new techniques for cleaning and cooling the cutting wire of a diamond wire saw. Princeton is currently seeking industrial collaborators to commercialize this technology. Conventional methods for cleaning the springs and beads of diamond wire saws use water to clean and cool the wire. This set up is undesirable where tritium or other contaminants may be present. This new system uses a non-exotic solid to clear away particulate matter that may gather in the springs and on the beads of diamond wire. The method also provides for...

Pattern-Free Method of Making Line Gratings

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:44 GMT

Researchers at Princeton University have developed a new method for forming micro linear arrays without the use of patterned masks or molds. Princeton is seeking industrial collaborators to commercialize this technology. Substrate-supported linear arrays are formed by the steps of adhering a thin layer of polymer between a pair of substrates and separating the substrates perpendicular to the layer. The polymer layer separates to form substrate-supported polymer gratings on both substrates, each grating having a period proportional to the thickness ...

Barium-Doped Bond Coats for Thermal Barrier Coatings

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:43 GMT

Docket # 08-2485-01 Researchers at Princeton have patented a new thermal barrier coating composition to protect aircraft jet engines and turbine engines for electrical power operating at otherwise prohibitively high temperatures. Improvements to the performance of thermal barrier coatings can lead to lower maintenance, lower energy costs, and longer operational lifetimes for coated machine components. A state-of-the-art thermal barrier coating (TBC) for a nickel-based jet engine consists of a nickel-aluminum alloy bond coat, a thermally protective yttria-stabilized...

IMPLEMENTATION OF BOOLEAN SATISFIABILITY WITH NON-CHRONOLOGICAL BACKTRACKING IN RECONFIGURABLE HARDWARE

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:41 GMT

Researchers at Princeton University have developed a novel method for implementing formula-specific Boolean Satisfiability solver circuits in configurable hardware. Princeton is currently seeking industrial collaborators to commercialize this technology. As the complexity of designing electronic systems increases, the effectiveness and efficiency of Computer Aided Design (CAD) tools becomes paramount. Techniques that accelerate core CAD algorithms can bring about important changes in product design times. This new method for accelerating automatic test pattern generation...

Operand-Value-Based Optimizations To Reduce Processor Power Consumption

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:40 GMT

Researchers at Princeton University led by Professor Margaret Martonosi have developed a novel technology to dramatically reduce power consumption in commercial microprocessors. Princeton is currently seeking industrial collaborators to commercialize this technology. State of the art processor designs have been pushed towards 64-bit word-widths because of the large address space needs in current applications. Although full 64-bit addresses and operations are indeed sometimes needed, arithmetic operations on much smaller quantities are still more common. Across the ...

A Novel and Effective Integer Optimization Approach for the NSF Panel Assignment Problem: A Multi-Resource and Preference ¿Constrained Assignment Problem

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:38 GMT

Princeton University Invention # 06-2223-1 In this work, an enhanced version of the generalized assignment problem (GAP), called the NSF panel assignment problem, is posed. The GAP has been the subject of considerable research over the last two decades and has many real life applications including job scheduling, production planning, modeling of computer and communication networks, storage space allocation, vehicle routing and facility location problems. The GAP seeks to determine the minimum ...

Improved Method of Manufacture of Carbon Nanotubes Using Carbon Arc Discharge

jdrayton@princeton.edu — Wed, 30 Nov 2011 15:11:37 GMT

Researchers at Princeton have developed a new method of manufacture of carbon nanotubes using a modified carbon arc discharge process that promises to be lower cost and easier to fabricate than current methods of production. Princeton is seeking an industrial partner to commercialize this technology. Current carbon arc discharge methods require the use of powdered catalyst mixtures packed into a hollow graphite anode, a time consuming process that entails some manufacturing risks regarding toxicity and f...

A New Design for Shifters in Computer Processors

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:53 GMT

Princeton Docket #07-2385-1 Researchers at Princeton University have developed a new design for shifters that utilizes Inverse Butterfly or Butterfly Routing Circuits. Princeton is currently seeking industrial collaborators to commercialize this technology. The design excels in its ability to perform permutations, so it can efficiently perform both existing shift operations (shift, rotate, extract, deposit and mix) that are currently supported by processors, as well as new advanced bit manipulation operations (bit gather or parallel extract, bit scatter or parallel deposit, and bit p...

Improved Mass Spectrometry for Sensitive and High-Throughput Whole Proteome Quantification

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:51 GMT

Princeton Docket # 10-2578 Current generation fourier-transform mass spectrometers (the Orbitrap and FTICR) coupled to online liquid chromatograpy (LC) separation and electrospray ionization (ESI) allow quantification of thousands of ions in complex mixtures. However, whole proteome tryptic digests, containing hundreds of thousands of peptides, which overwhelm the capabilities of these instruments. Researchers in the Department of Molecular Biology, Princeton University have developed an LTQ- Orbitrap based-method for targeted quantification of intact peptides...

A Computational Model for Precisely Decoding Complex Chemical Mixtures with Chemosensory Arrays

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:50 GMT

Princeton Docket # 10-2599 To date, analysis of chemosensory array (¿artificial nose¿) data has been generally limited to ¿fingerprinting¿ or ¿pattern recognition¿ methods of data analysis. These methods do not factor in the physical nature of mixed, cross-inhibitory signals from multiple ligands. This means that chemosensory arrays based on non-specific receptors are not optimized to account for ¿crosstalk¿ among analytes, which significantly limits their utility. It also means that sensory arrays must frequently rely on highly specific ligand-receptor interactions if ...

Collaborative Mathematical Workbench Software

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:49 GMT

Princeton Docket # 11-2681-1 Researchers at Princeton Plasma Physics Laboratory have developed new software that provides an integrated software environment for exploring, modifying and displaying data. Physicists at different locations often work on the same projects and need to collaboratively share and manipulate data. The software can also be used to teach Python programming and mathematical computation in a classroom setting where each student and the instructor have workstations. The collaborative capability enables an instructor to work interactively with a group of students. The i...

Novel Method for the Production of Upgraded and Fresh Water from Saline, Brackish and Polluted Waters

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:48 GMT

Princeton Invention # 06-2206 The availability of fresh water for drinking, domestic and industrial uses is a growing problem in many parts of the world. Reverse osmosis and evaporation methods are currently in wide use for water remediation, notably in Saudi Arabia where potable water is produced on a large scale from sea water. Electrodialysis and freezing methods have been less applied. The economics of all these processes depend on the water source and on the facilities and environmental problems at t...

New Antimicrobial and Antitubercular Pleuromutilin like Compounds

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:47 GMT

Princeton University Invention # 10-2570 Researchers in the Department of Chemistry, Princeton University have developed a concise and efficient way to create an expanded set of compounds with features of pleuromutilin. This pathway for synthesis is capable of giving access to compounds that could never be constructed from the natural product pleuromutilin by semi-synthetic methods. The invention utilizes commercially available chemicals and several classical and contemporary chemical reactions in syntheses of the pleuromutilin-like compounds. In principle, the chem...

A Fast, Reliable Method for Predicting Allosteric Coupling for Targeted Drug Design and Analysis of Protein Stability

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:46 GMT

Princeton Docket # 10-2609 Researchers at the Lewis-Sigler Institute for Integrative Genomics, Princeton University have developed a novel method for computing information about a protein¿s preferred three-dimensional structure from its amino acid sequence. Using a simple set of assumptions, the method utilizes the pattern of hydrophobicity in the protein¿s sequence to calculate the optimal and nearly optimal structures for that sequence in seconds. This information may be utilized as a guidance system for many applications, including targeted drug ...

Novel Catalysts for Hydrogenation of Olefins: Low Cost, Low Toxicity, and High Enantioselectivity

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:45 GMT

Princeton Docket #s 12-2718-1, 12-2719-1, 12-2720-1 Homogeneous catalysis with transition metals has transformed the art and science of chemical synthesis. The industrial synthesis of most commodity and fine chemicals, including pharmaceuticals, rely on one or more transition metal catalyzed steps. Traditionally these catalysts are based on precious metals of the second and third rows of the transition series and often suffer from high cost, toxicity, limited availability and pose environmental concerns. This new technology replaces these elements in homogeneous catalysis with more ...

HARDWARE TRUST ANCHORS IN SP-ENABLED PROCESSORS

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:44 GMT

Princeton Docket #09-2495-1 Researchers at Princeton have developed a new device to improve the security of computers, communication devices and entertainment devices. The invention consists of a set of hardware registers and mechanisms that define a small set of fundamental hardware trust anchors, and cryptographic and tagging mechanisms that can be implemented in any processor or SOC used in computing, communications or entertainment devices. It is made by building the SP hardware features into any processor chip or SOC (system on chip) or FPGA attachment. These new SP hardw...

A Novel, Computational Method for the Quantification of Histone Post-Translational Modifications using LC-MS/MS

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:42 GMT

Princeton Docket # 11-2630-1 Researchers in the department of molecular biology Princeton University have developed a method that directly incorporates chromatographic relationships between modified forms into post-translational modifications (PTMs) identification and quantitation problems. In particular, this method establishes a priori relative elution relationships between modified forms of the same peptide with respect to the type of chromatography (e.g., reversed phase) used to separate the sample mixture. These relationships are then built into the model, whi...

Improved Method for Election Auditing

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:40 GMT

Researchers at Princeton University have developed an improved method for auditing the results of elections. Princeton is currently seeking an industrial partner to commercialize this technology. The new method allows an audit that will detect common types of election fraud or malfunction with a high degree of probability. The method combines a machine-conducted audit of some ballots with a manual audit of a smaller number of ballots, thereby combining the cost advantages of machine-co...

S-MART: A MONETARY SYSTEM OF PRICING AND TRADING FOR CONTENT SHARING

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:38 GMT

Researchers at Princeton University have developed a system design for peer-to-peer computer networks for content sharing. Princeton is currently seeking an industrial collaborator to commercialize this technology. The new system proposes creating a market economy for user-submitted content while providing income for the system provider through a commercial advertisement mechanism to enable system upkeep and development. It introduces an economic system having its own virtual currency for Internet users to come...

A Universal Framework for Regulatory Element Discovery across All Genomes and Data-types

jdrayton@princeton.edu — Wed, 30 Nov 2011 11:37:37 GMT

Princeton University Invention # 08-2427 Understanding the mechanistic basis of gene regulation is a central challenge for modern biology, and success in this domain is fundamental to a rational basis for understanding and treating human disease. One set of modern methods attempt to systematically relate gene expression measurements (microarrays) and sequence, in order to identify short regulatory elements that are causally relate...

Absorption Line Filter Window and Method for Velocity Measurements by Light Scattering

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:14 GMT

Researchers at Princeton University have developed a novel technique for measuring the velocity of air flow by observing velocity-related frequency shifts in light scattered from moving air molecules or particles suspended in the moving air. Scattered light is passed through an absorption line filter window gas cell with a notch type attenuation profile as a function of frequency. The scattering region is illuminated with a narrow linewidth light source coincident in frequency with a strong absorption line of an absorption line filter. Light scattered from stationary air mo...

METHOD FOR MAKING MULTILAYER THIN FILM ELECTRONICS

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:13 GMT

Method for Making Multilayer Thin-Film Electronics Princeton Docket #98-1471 Researchers at Princeton University have developed a novel new method for the high speed manufacture of multilayer electronic components on flexible substrates for uses such as emissive displays. Princeton is currently seeking industrial collaborators to commercialize this technology. Currently, high-yield production of multilayer emissive displays requires the separate manufacture of the various layers, such as the thin film transistor layer (TFT backplane) and organic light emitting d...

Optimal Push/Pull Proxy Gateway for Wireless Internet Services

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:12 GMT

Researchers at Princeton University have developed a novel method to improve access speed and service efficiency of mobile Internet users. Princeton is currently seeking industrial collaborators to commercialize this technology. Wireless Internet services are one of the most rapidly expanding segments in the information technology industry. The push/pull proxy gateway, which interfaces between the mobile user and the server, is the most important device between the wired and wireless networks. The technology of push/pull proxy gateway is currently based on cache...

SCHEDULING OF SWITCHED MULTIBEAM ANTENNAS IN A MULTIPLE ACCESS ENVIRONMENT

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:11 GMT

Researchers at Princeton University have developed a new smart antenna for direct sequence code division multiple access (DS-CDMA) wireless communication systems operating in a multipath Rayleigh flat-fading channels. Princeton is currently seeking industrial collaborators to commercialize this technology. The novelty of the new switched beam antenna array relies on designing a new beamforming device that switches between a candidate set of fixed beams multiple times per symbol. A Kalman filter is used to estimate the attenuated spread spectrum signals for all users an...

A HIGH SENSITIVITY ATOMIC MAGNETOMETER FOR THE DETECTION OF NITROGEN-CONTAINING EXPLOSIVES

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:10 GMT

Researchers at Princeton University have developed a novel high sensitivity magnetometer having the ability to detect and measure very low magnetic field intensities. The device relies on polarizing alkali metal vapor, and probing the state of magnetization of the polarized metal atoms to measure characteristics of a magnetic field originating from a variety of sources. The device is a radio-frequency tunable atomic magnetometer for detection of nuclear quadrupole resonance (NQR) from room temperature solids, including detection of nitrogen-c...

Method for Self-Repair of Defects in Nano-Structures

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:09 GMT

Researchers at Princeton University have developed a new method for repairing and thereby reducing defects in a patterned nanoscale device by liquifying the patterned device in the presence of appropriate guiding conditions for a period of time and then permitting the device to re-solidify. The performance of such nanoscale devices typically depends on the shapes and dimensions of their structures, and they are typically designed with precise shapes and dimensions to perform a desired function. They ...

QUASICRYSTALLINE STRUCTURES AND USES THEREOF

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:08 GMT

Princeton University Invention # 06-2217 Researchers in the Department of Physics, Princeton University have developed an optical device known as an icosahedral photonic quasicrystal. The significance of such a device is that it makes it possible to control which bands of photons are passed through and which are blocked. The studies performed at Princeton confirm that these devices may be excellent candidates for fully three-dimensional photonic band gap materials as published in Nature (see reference below). The device developed at Princeton consists of a quasicrystalline arra...

Blind Estimation of Multiple Carrier Frequency Offsets

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:06 GMT

Researchers at Princeton University and Drexel University have developed a new process for signal processing related to wireless communications, specifically to provide blind CFO estimation and symbol recovery. Princeton is currently seeking industrial collaborators to commercialize this technology. This invention addresses the problem of carrier-frequency offset estimation in distributed antenna systems.&nb...

A Scheme for Initial Ranging in OFDMA-Based Networks

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:05 GMT

Researchers at Princeton University and the University of Pisa have developed a novel Initial Ranging scheme for OFDMA networks where carrier frequency offsets, timing errors and power levels are estimated for all ranging subscriber stations. Princeton is currently seeking industrial collaborators to commercialize this technology. Existing Initial Ranging schemes estimate the timing offsets and power levels of ranging...

NONLINEAR RECOVERY OF NOISE HIDDEN SIGNALS AT LOW LIGHT LEVELS

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:05 GMT

Princeton Docket #08-2453 Researchers at Princeton University have developed a new process of filtering and enhancing signals from a noisy background, based on the non-linear interaction between coherent and incoherent waves. Princeton is currently seeking industrial collaborators to commercialize this technology. The new process is an all-optical method of amplifying low-level signals and also provides a novel method for hiding information and recovering it. It works for both spatial and temporal pulses. ...

Method for Synchronizing the Phase and Frequency of Two or More Wireless Transmissions

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:04 GMT

Researchers at Princeton University have developed a system and method for multi-node beamforming, a method/protocol of synchronizing two or more independent wireless transmitters to enable transmission as a ¿virtual array antenna¿ which can lower overall needed transmission power (increasing battery life), increase the signal to noise ratio at the receiver, and lower the signal quality for any eavesdroppers. The new technology solves prior issues with distributed beamforming systems relate...

A HIGH SENSITIVITY ATOMIC MAGNETOMETER UNAFFECTED BY SPIN-EXCHANGE RELAXATION

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:01 GMT

Researchers at Princeton University have developed a novel high sensitivity magnetometer. Princeton is currently seeking industrial collaborators to commercialize this technology. This new device uses polarized atoms to measure magnetic fields, permitting sensitivity up to two orders of magnitude greater than currently used Alkali-Metal and SQUID magnetometers as well as allowing for continuous three-dimensional mapping of the magn...

Novel Method For Making Complementary Metal-Oxide-Silicon (CMOS) Circuits

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:53:00 GMT

Researchers at Princeton University led by Professor Sigurd Wagner have developed a novel technology to make CMOS circuits utilizing process temperatures below 320O C . Princeton is currently seeking industrial collaborators to commercialize this technology. State of the art CMOS processing techniques require process temperatures above 600O C because that is the lowest temperature at which polycrystalline films can be made by thermal crystallization. The Princeton invention allows for the manufacture of such circuits at temperature almost 300O C lower...

Rapid and Minimally Invasive Quantum Cascade Wafer Testing

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:10:40 GMT

Princeton University Invention # 09-2523 Quantum Cascade (QC) wafer quality testing requires intensive processing and characterization. Conventional techniques used for wafer quality testing include photoluminescence, x-ray diffraction, Hall effect measurements, high resolution x-ray diffraction, transmission electron microscopy and secondary ion mass spectrometry, all of which are useful but are time consuming and highly invasive. More importantly, none of these methods are complete in that they do not give the necessary QC information, such as turn-on voltage, maximu...

A Scheme for Lossy Joint Source-Channel Coding

jdrayton@princeton.edu — Tue, 29 Nov 2011 12:10:38 GMT

Researchers at Princeton University have developed a solution for the simultaneous lossy transmission of a natural source (such as images, audio and video) over a one-to-many (broadcast) channel under a quadratic distortion fidelity criterion. Princeton is currently seeking an industrial collaborator to commercialize this technology. Conventional approaches to multimedia streaming over heterogeneous digital networks consist of establishing individual streaming sessions from the server to each user.&nb...

Low-Cost Single-mode Quantum Cascade Lasers

jdrayton@princeton.edu — Tue, 29 Nov 2011 11:37:33 GMT

Princeton Docket # 10-2622 Currently available commercial single-mode QC lasers either employ distributed feedback or external cavity technique to achieve single-mode emission. Due to the complexity and yield issue of these techniques, the costs and thus the sale prices for single-mode QC lasers are very high, which is a crucial barrier to the development of applications. This invention permits single-mode operation of QC lasers with folded Fabry-Perot cavities, which solves the problem that QC lasers with conventional straight Fabry-Perot cavities ...

Remote Detection of Molecular Species Using Air Laser

jdrayton@princeton.edu — Tue, 29 Nov 2011 11:37:32 GMT

Researchers at Princeton University have developed a novel method of lasing in air that could be used for long range detection of molecular species, such as atmospheric pollutants or chemicals. Princeton is currently seeking industrial collaborators to commercialize this technology. The technology employs the use of a near infrared laser to dissociate oxygen or nitrogen molecules into atomic oxygen or nitrogen and then causes the excitation of that atomic oxygen or nitrogen by two photon absorption. This leads to laser beams propagating in both the forward and reverse dire...

An Innovative Tool for Isotopic Ratio Measurements, Environmental Monitoring and Gas Sensing for Industrial Process Control

jdrayton@princeton.edu — Tue, 29 Nov 2011 11:37:31 GMT

Princeton Docket # 12-2762 Researchers at Princeton University have developed differential optical dispersion spectroscopy (DODiS), a precise trace-gas sensing technology that enables direct optical subtraction of dispersion spectroscopic signals produced by two different gas samples. Princeton is currently seeking industrial collaborators to commercialize this technology. Advantages - Truly optical subtraction of spectroscopic signals - Direct sensing of concentration differences, also for highly absorbing samples - Selective suppression of unwanted backgroun...

Chirped Laser Dispersion Spectroscopy for remote sensing

jdrayton@princeton.edu — Tue, 29 Nov 2011 11:37:30 GMT

A device and method for path-integrated optical sensing and simultaneous retroreflector tracking using a multi-functional position-sensing photodetector Princeton Docket # 11-2700-1 Detection of molecular species is of importance in a number of industrial, health and atmospheric monitoring applications. Existing spectroscopic gas sensing instrumentation has some fundamental limitations, primary due to the fact that signals carrying the useful information are encoded in light intensity, thus the measurements are strongly affected by fluctuations of the laser power reaching the photodetector....

New Structure and Manufacturing Process for Silicon Solar Cells

jdrayton@princeton.edu — Tue, 29 Nov 2011 11:37:28 GMT

Researchers at Princeton have developed a new method of fabrication of silicon solar cells that enhances efficiency, does not require high-temperature heating in ultra-clean furnaces, and allows processing in a continuous, rather than a batch process. Princeton is currently seeking an industrial partner to commercialize this technology. Under this new process, a silicon base layer can be coated with organic ...

Novel Gene Induction and Protein Degradation Systems: A rapid and specific tool for gene function studies and high throughput screening for target identification and drug discovery

jdrayton@princeton.edu — Tue, 22 Nov 2011 11:48:51 GMT

Princeton Docket # 11-2672 Researchers at Princeton University have developed a novel system for the rapid and specific induction of individual genes, and upon modification, this system also allows for the rapid and specific degradation of target proteins. Substantial induction/degradation of target genes/proteins can be achieved within minutes following the addition of an inducing molecule, b-estradiol. This inducer was shown to be truly gratuitous in that it interacts with no other regulatory system and has minimal effects on the physiology of the cells except for ...

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water

jdrayton@princeton.edu — Tue, 22 Nov 2011 11:16:06 GMT

Princeton Docket # 11-2630-1 Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions and without the input of external energy or use of harsh chemicals, circumventing the major concerns of large-scale production of ClO2 as well as providing a low-tech, green option for water purification. Applications: - Production of ClO2 for treatment of drinking water - Catalytic method to pr...

Jagged1, a marker and therapeutic target for breast cancer bone metastasis

jdrayton@princeton.edu — Fri, 04 Nov 2011 08:10:17 GMT

Princeton Docket # 11-2669 Although several molecular contributors of bone metastasis have been identified, effective therapies still await a more comprehensive understanding of the complex molecular and cellular networks of tumor stromal interactions in bone metastasis. Researchers in the Department of Molecular Biology, Princeton University have discovered that (1) elevated expression of the Notch pathway ligand Jagged1 is associated with decreased relapse-free or bone metastasis-free survival in patients, (2) tumor-derived Jagged1 promotes bone metastasis of breast cancer through...

Non-invasive device for measuring compounds and dissolved gasses in biological tissue using infrared absorption/reflection spectroscopy

jdrayton@princeton.edu — Fri, 29 Jan 2010 10:10:06 GMT

Princeton University Invention # 09-2525 Researchers in the Department of Electrical Engineering and the MIRTHE Research Center, Princeton University have developed an eye-safe device that allows for non-invasive measurements of dissolved gasses and compounds in a patient¿s blood and tissue. Operating similar to a pulse-oximeter, health care practitioners (and patients in-home) can monitor biological compounds and gasses such as carbon dioxide, acetone, and potentially glucose. Current methods of monitoring such compounds rely on the drawing and analysis of blood samples. T...

Design and Use of an Acoustically Tunable Beam Shaping Apparatus

jdrayton@princeton.edu — Fri, 29 Jan 2010 10:09:52 GMT

Design and Use of an Acoustically Tunable Beam Shaping Apparatus Princeton University Invention # 07-2369 Fixed lenses are conveniently used for shaping the intensity patterns or wavefronts of light, however there are needs for frequent reshaping which requires adaptive optical elements. There are a number of such active technologies, each with advantages and shortcomings. To overcome limitations such as speed and energy throughput for materials processing applications, Researchers at Princeton U...

Novel Inhibitors for HIV-1 gp41

jdrayton@princeton.edu — Fri, 29 Jan 2010 10:09:48 GMT

Novel Inhibitors for HIV-1 Princeton University Invention # 09-2547

C3aR Antagonists

jdrayton@princeton.edu — Fri, 29 Jan 2010 10:09:45 GMT

Princeton University Invention # 10-2571 Using a novel computation framework, researchers at Princeton University and the University of California, Riverside, have identified potent antagonists of the C3a receptor (C3aR). Inhibition of binding of C3a to C3aR is an excellent target for drug design against autoimmune and inflammatory diseases involving under-regulated complement system activation. These peptides have been tested experimentally using Chem-1 C3aR stable cells and calcium mobilization assays. The most potent peptide showed reduction of C3a full response to 5% at ...

Efficient and Scalable Algorithm for Surveying Relative Abundance of Biologically Important Compounds in High Resolution LC-MS/MS Data

jdrayton@princeton.edu — Fri, 29 Jan 2010 10:09:42 GMT

Princeton University Invention # 08-2458 Princeton researchers in the Computer Science Department and the Lewis Sigler Institute for Integrative Genomics have developed an efficient and accurate algorithm that processes large volumes of high resolution mass spectrometry data. The technology enables unprecedented surveys of protein, metabolite, and lipid abundances, and thus, promises to aid in the discovery of new biology and commercially important pharmaceuticals and disease bio-markers. Cells and tissues contain...

An Easy and Efficient Method for Engineering Large Synthetic Constructs into the Chromosome

jdrayton@princeton.edu — Fri, 29 Jan 2010 09:38:53 GMT

Princeton University Invention # 10-2603 Researchers in the Department of Molecular Biology, Princeton University have developed an efficient, easy to use, two-step system for the site-directed insertion of large genetic constructs into arbitrary positions in the Escherichia coli chromosome. This system can also be used for the integration of large DNA fragments into bacterial artificial chromosomes (BACs) and plasmids. The system uses λ-Red mediated recombineering accompanied by the introduction of double-stranded DNA breaks in the chromosome and a donor plasmid bearing th...

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Quench Protection of Superconducting Coils using Inductively Coupled Conductors

Ironless Linear Induction Motor Actuator for Magnetic Field Environment

Method for Reinforcement, Quench Protection, and Stabilization of Large All-Metal Superconducting Magnets [PPPL No. M-1054]

Confocal Laser Induced fluorescence diagnostic with annular laser beam for large focal distances

3D Printed Active Electronic Materials and Devices

Variable Radii Bitter Spiral Crystal Spectrometer

DNA Valency Sorting Chromatography for Separating Large Solutes

New biological method for producing semiconductor quantum dots using de novo proteins

A Quantitative Screen for the Assessment of Microbiome Derived Drug Metabolism

Spheromak Gun for Inductive flux Injection

Optical Counting and Localization of Suspended Particles Using a Hough Transform

Debris mitigation in laser produced plasmas using three-dimensional manipulation of magnetic topology

­Permanent Magnet Stellarator Design

Low-Temperature Plasma Device for Sterilization and Anti-Viral Applications (PPPL)

A rocket thruster that could take humans to Mars and beyond

Metabolomics Explorer (MetEx) for Cryptic Natural Products or Antibiotic Drug Discovery

A New Target for Pseudomonas aeruginosa Drug Discovery

Hand Sanitizer Gels from Sustainable Resources for Various Skin Types

Method of Assessing Bacterial Viability on Low Biomass Environments

C. elegans retrotransposon Cer1 as a Delivery Mechanism for RNA-based Therapeutics

Glycopeptide Antibiotic Combination Therapy Against Clostridial Infections, In Particular, C difficile

CeLab: A Miniature Easy to Use C. elegans Lab on a Chip for Research

Tryglysin A and B Novel, Selective, and Potent Antibacterial Agents Against Streptococcus Bacteria

ReChat - An Integrated and Interactive Chat Suite for Online Survey Experiments

Human IDO1- Selective Agonists for Treating Autoimmune Disorders

A New Tool for Gene x Enviroment (GxE) Research - Variation Polygenic Score (vPGS)

Trendme- Ratings in Real Time for Bettter Decisions for Consumer Goods and for Providers in Improved Services and Goods

Plasma Systems for Air Decontamination

Self-Disinfecting Reverse Adhesive Bandages

Blink Lab – A Simple, Low Cost, Non-Invasive Tool for Use in Neurological and Psychiatric Disorders

Macrocyclic Peptides: Novel Antibiotic Treatment against Staphylococcus Aureus

Novel Method to Monitor the Viral Proteome Throughout Infection for Use in Anti-Viral Drug Discovery and Vaccine Development

Novel Small Molecule Agent for the Dispersal of Pseudomonas Aeruginosa, and other Type IV Pili Bacteria

Plasma Based in-situ Method to Sanitize in Real Time Door Knobs, Handles, Medical Equipment, Push Buttons, and Other Surfaces

Chemically Enhanced Plasma Sterilizer (CEPS)

Low-Temperature Plasma Device for Sterilization and Anti-Viral Applications

Self-Disinfecting Plasma Fabric

Solar Water Purification and Decontamination Hybrid Hydrogel

An Early Genetic Screening Aid in the Selection of Dogs for Assistance Training Programs

Permanent Magnet Stellarator Design