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Antibacterial Adjuvants for Reduced Cationic Antimicrobial Peptide Dosing and Combination TherapyPrinceton Docket # 20-3616-1 Researchers in the Department of Chemistry at Princeton University and the Department of Chemistry at San Jose State University have discovered compounds which increase the susceptibility of both CAP-resistant as well...
Published: 2/15/2023
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Inventor(s): Laura Conrad, Martin Semmelhack, Zinan Zhang, Minh Tran, Lauren Blankenship
Keywords(s): antibiotics
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 16-3183-1Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a nanocarrier based approach to enable and enhance adjunctive therapies for microbial infections by simultaneous encapsulation and delivery of all components.Microbial infections have become increasingly difficult to...
Published: 2/14/2024
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Inventor(s): Robert Prud'homme, Hoang Lu
Keywords(s): antibiotics, drug delivery, Imaging, nanotechnology
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/30/2022
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies
Princeton Docket # 15-3064
Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets
host-pathogen interactions,...
Published: 2/14/2024
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Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Princeton Docket # 14-3007
Researchers in the Department of Molecular Biology at Princeton University have isolated a mutant strain of Escherichia coli that is specifically more resistant to vancomycin than is its wild-type parent. The resistance mutation in this strain alters an enzyme normally involved in LPS biosynthesis causing it to synthesize...
Published: 9/8/2022
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Inventor(s): Thomas Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
Keywords(s): antibiotics, antibody, immunology, therapeutic, vaccines
Category(s): Biotechnology/Pharmaceuticals
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Methods and Microfluidic Device for the Study, Testing and Treatment of Biofilm Formation in Environmental, Medical, or Industrial Devices Docket # 13-2880Researchers at Princeton University have developed a microfluidic system and method to investigate biofilm morphologies under more realistic physical conditions which could be used to screen potential...
Published: 9/8/2022
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Inventor(s): Bonnie Bassler, Howard Stone, Martin Semmelhack, Knut Drescher, Yi Shen, Colleen O'loughlin, Laura Miller Conrad
Keywords(s): antibiotics, anti-infectives, Biotechnology/Pharmaceuticals, life science research tools, medical device
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Princeton Dockets # 08-2418, 12-2775 &
12-2776
Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening
disease. It is estimated that
cholera affects 3-5 million people worldwide, and causes
100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and
cotrimoxazole have been used to shorten the...
Published: 3/30/2022
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Inventor(s): Martin Semmelhack, Bonnie Bassler, Lark Perez, Megan Bolitho, Matthew Koch, Wai-Leung Ng
Keywords(s): antibiotics, Biotechnology/Pharmaceuticals, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 08-2467 & 08-2486
Researchers at
Princeton University, Department of Molecular Biology, have identified and
synthesized small molecule antagonists that could serve as broad spectrum lead
compounds for the disruption of quorum sensing in pathogenic Gram-negative
bacteria. In proof of principle experiments, potent antagonist...
Published: 1/23/2024
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Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 11-2663
Researchers
at Princeton University created novel peptide derivatives of the antimicrobial
peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent
activity against Gram-negative bacteria. The most potent MccJ25 variants
displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/21/2022
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Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Quorum
Sensing is an essential form of intercellular communication used by many types
of common bacteria, and many pathogenic bacteria use quorum sensing to attack
and invade the human host. Quorum Sensing is used by bacteria to detect a
critical cell number, which is the cell population required for pathogenic
bacteria to release effective...
Published: 6/30/2023
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Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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