· Reduced resistance development
· Less damage to commensal flora than conventional antibiotics
· Expanded range of bacterial species whose nitric oxide defenses depend on ClpP protein than pathogenic E. coli
Nitric oxide, kinetic modeling, Escherichia coli, ClpP protein, anti-infective, antibiotic, cell toxicity, host-pathogen interaction, cell defense system
Robinson, J.L. and Brynildsen M.P. An ensemble-guided approach identifies ClpP as a major regulator of transcript levels in nitric oxide-stressed Escherichia coli. Submitted, 2015.
Robinson J.L. and Brynildsen M.P. A kinetic platform to determine the fate of nitric oxide in Escherichia coli. PLoS Computational Biology, 2013. 9(5):e1003049.
Jonathan Robinson and Mark Brynildsen, Ph.D.
Mark Brynildsen, Assistant Professor in Chemical and Biological Engineering
The Brynildsen research group is a network biology and metabolic engineering lab that uses both computational and experimental techniques in systems biology, synthetic biology, and metabolic engineering to understand and address threats to human health. The lab currently focuses on the global public health crisis of antibiotic resistance and is interested in the specific areas of antivirulence therapy, bacterial persistence, and biofilms.
Dr. Mark Brynildsen completed his graduate work with Professor James Liao in 2008 at the University of California, Los Angeles, where he was awarded the California NanoSystems Institute Graduate Student Fellowship, the Arco Graduate Student Fellowship, and the UCLA Dissertation Year Fellowship. He was an Howard Hughes Medical Institute Postdoctoral Associate at Boston University from 2008-2010. He then joined the faculty of Princeton University in the Department of Chemical and Biological Engineering, where he has started his research group.
Intellectual Property Status
Patent applications are pending. Princeton is seeking industrial collaborators for further development and commercialization of this technology.
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