Search Results - biomarker/diagnostic

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Oocyte Quality Evaluation for Reproduction Prediction

Princeton Docket # 15-3076-1Researchers in the Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton University have discovered biomarkers that are indicative of oocyte quality. This invention is a new diagnostic tool for female reproductive status that will use biomarkers of oocyte quality to predict ...
Published: 6/17/2016   |   Inventor(s): Coleen Murphy
Keywords(s): biomarker/diagnostic, female health, healthcare
Category(s): Biotechnology/Pharmaceuticals

Blocking bacterial infection by inhibiting surface-regulated virulence induction

Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 7/10/2015   |   Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): anitbiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells ...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the disc...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

ClpP is a Major Regulator in NO Stressed E Coli

Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies Princeton Docket # 15-3064 Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets host-pathogen inte...
Published: 3/24/2015   |   Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): anitbiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of ...
Published: 1/26/2015   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Novel Cell Line for Hepatitis B Drug Discovery and Research

Novel Cell Line for Hepatitis B Drug Discovery and Research Princeton Docket # 15-3077 Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate th...
Published: 1/14/2015   |   Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals

Polymer Janus Nanoparticles by Flash NanoPrecipitation

Polymer Janus Nanoparticles By Flash NanoPrecipitation Princeton Docket # 14-2981 Janus particles are characterized by two physically distinct regions within or on the surface of the particle. Polymer Janus nanoparticles, in particular, contain at least two different polymer regions. At present, only a few ingenious routes for the generation o...
Published: 12/8/2014   |   Inventor(s): Rodney Priestley, Robert Prud'homme, Chris Sosa
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, catalyst, Chemistry, drug delivery, Imaging
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Chemistry

Integrated CMOS On-Chip Fluorescence Bio-Sensor and Microscopy System

Integrated CMOS-based Single–chip Fluorescence Bio‐Sensor SystemDocket # 14-2990Integrated, low‐cost and portable point‐of‐care diagnostic technology has the potential to bring transformative changes in healthcare by enabling early detection of diseases in a remote field setting, allowing timely and rapid treatment to the patient and facilita...
Published: 10/30/2014   |   Inventor(s): Lingyu Hong, Kaushik Sengupta
Keywords(s): biomarker/diagnostic, computers/software, medical device, semiconductor
Category(s): Computers and Software, Medical Devices/Diagnostics

Noninvasive Mid-Infrared In Vivo Glucose Sensor

Noninvasive Mid-infrared in vivo Glucose Sensor Princeton Docket # 14-2945 Researchers in the Department of Electrical Engineering at Princeton University have developed a novel, noninvasive method to measure blood glucose levels. Development of this noninvasive in vivo glucose sensor may improve the quality of life for the more than 343 million d...
Published: 1/28/2014   |   Inventor(s): Sabbir Liakat, Claire Gmachl, Anna Michel
Keywords(s): biomarker/diagnostic, diabetes, laser, life science research tools, medical device
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Mechanical/Electrical Engineering
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