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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Iodine-Based Nanoparticles for Diagnostic Medical Imaging Applications
Princeton Docket # 14-2943
Non-invasive medical imaging techniques such as X-ray-Computed Tomography (CT) and Positron Emission Tomography (PET) are powerful tools in diagnostic medicine. In these applications, contrast agents are needed to enhance the diagnostic quality of the...
Published: 2/14/2024
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Inventor(s): Christina Tang, Robert Prud'homme
Keywords(s): cancer/oncology, Imaging
Category(s): Medical Devices/Diagnostics
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Identification of Novel Isoforms of a Gene and
Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of
Cellular Motility, Migration, and/or Invasion
Princeton Docket # 13-2929-1
High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple mRNAs...
Published: 3/30/2022
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Inventor(s): Hilary Coller, David Corney
Keywords(s): biomarker/diagnostic, cancer/oncology, life science research tools, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Docket # 13-2834-1The market for biological microscopes is greater than $1 billion annually. There is a high demand in the biomedical research field for microscopes which are capable of resolving ever smaller features and faster dynamics in live cells. However, currently available biological microscopes are limited in their ability to follow phenomena...
Published: 12/12/2022
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Inventor(s): Haw Yang, Kevin Welsher
Keywords(s): anti-infectives, anti-viral, Biotechnology/Pharmaceuticals, cancer/oncology, Imaging, life science research tools, microscopy, research tool
Category(s): Medical Devices/Diagnostics, Chemistry, Biotechnology/Pharmaceuticals
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Novel Stapled BH3 Peptides
Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple
Cancers
Princeton Docket # 12-2785-1
Researchers in the Department of Chemical and Biological Engineering Princeton
University have identified novel stapled peptides, which have been
engineered to have high cytotoxic activity against several...
Published: 2/17/2023
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Inventor(s): Aaron James Link, Siyan Zhang
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 12-2807
Researchers
in the Molecular Biology Department at Princeton University have discovered a
group of miRNAs as novel therapeutics for bone metastasis. Through
a series of in vitro and in vivo experiments, five distinctive miRNAs have been
identified as inhibitors of osteoclast differentiation. Further, systemic
treatment...
Published: 3/30/2022
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Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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A target and
screening system for the identification of therapeutic candidates against
secondary viral infections in cancer and immunocompromised
diseases
Docket # 12-2771
Researchers in the
molecular biology department at Princeton University, together with researchers
in the department of microbiology and immunology, School of Medicine, University...
Published: 3/30/2022
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Inventor(s): Danna Hargett, Stephen St. Jeor, Lisa Keyes, Mariana Bego
Keywords(s): anti-viral, cancer/oncology, drug target, human cytomegalovirus, immunocompromised
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
11-2633
The ability to
selectively kill quiescent cells could be a powerful tool in medicine. In
particular, the ability to kill the quiescent tumor stem cells could be an
important addition to our chemotherapeutic repertoire. A better understanding of
the transition between quiescent and activated cellular states of fibroblasts...
Published: 3/30/2022
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Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton University Invention #
08-2484
Cisplatin is a
leading chemotherapy agent; however its effectiveness is limited by its severe
side effects. Researchers at Princeton University and the University of
Medicine and Dentistry New Jersey, Department of Chemistry and Department of
Pathology and Laboratory Medicine, respectively have synthesized...
Published: 3/30/2022
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Inventor(s): Andrew Bocarsly, Patricia Fitzgerald-Bocarsly, Amanda Tricarico, Kate Keets
Keywords(s): cancer/oncology, drug delivery
Category(s): Biotechnology/Pharmaceuticals
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