Search Results - cancer%2foncology

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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Iodine-Based Nanoparticles for Diagnostic Medical Imaging Applications

Iodine-Based Nanoparticles for Diagnostic Medical Imaging Applications Princeton Docket # 14-2943 Non-invasive medical imaging techniques such as X-ray-Computed Tomography (CT) and Positron Emission Tomography (PET) are powerful tools in diagnostic medicine. In these applications, contrast agents are needed to enhance the diagnostic quality of the...
Published: 4/1/2014   |   Inventor(s): Christina Tang, Robert Prud'homme
Keywords(s): cancer/oncology, Imaging
Category(s): Medical Devices/Diagnostics

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications

Identification of Novel Isoforms of a Gene and Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of Cellular Motility, Migration, and/or Invasion Princeton Docket # 13-2929-1 High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple mRNAs...
Published: 11/1/2013   |   Inventor(s): Hilary Coller, David Corney
Keywords(s): biomarker/diagnostic, cancer/oncology, life science research tools, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Three Dimensional Multi-resolution Microscope (3DMM) for High-definition Imaging of Cell-biological Events

Docket # 13-2834-1The market for biological microscopes is greater than $1 billion annually. There is a high demand in the biomedical research field for microscopes which are capable of resolving ever smaller features and faster dynamics in live cells. However, currently available biological microscopes are limited in their ability to follow phenomena...
Published: 3/14/2013   |   Inventor(s): Haw Yang, Kevin Welsher
Keywords(s): anti-infectives, anti-viral, Biotechnology/Pharmaceuticals, cancer/oncology, Imaging, life science research tools, microscopy, research tool
Category(s): Medical Devices/Diagnostics, Chemistry, Biotechnology/Pharmaceuticals

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers Princeton Docket # 12-2785-1 Researchers in the Department of Chemical and Biological Engineering Princeton University have identified novel stapled peptides, which have been engineered to have high cytotoxic activity against several different...
Published: 12/20/2012   |   Inventor(s): Aaron James Link, Siyan Zhang
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry
Category(s): Biotechnology/Pharmaceuticals

MiRNAs as Novel Therapeutics and Non-invasive Biomarkers for Bone Metastasis

Princeton Docket # 12-2807 Researchers in the Molecular Biology Department at Princeton University have discovered a group of miRNAs as novel therapeutics for bone metastasis. Through a series of in vitro and in vivo experiments, five distinctive miRNAs have been identified as inhibitors of osteoclast differentiation. Further, systemic treatment...
Published: 4/27/2012   |   Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

A Target and Screening System for the Identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseaes

A target and screening system for the identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseases Docket # 12-2771 Researchers in the molecular biology department at Princeton University, together with researchers in the department of microbiology and immunology, School of Medicine, University...
Published: 4/25/2012   |   Inventor(s): Danna Hargett, Stephen St. Jeor, Lisa Keyes, Mariana Bego
Keywords(s): anti-viral, cancer/oncology, drug target, human cytomegalovirus, immunocompromised
Category(s): Biotechnology/Pharmaceuticals

Inducing apoptosis in quiescent cells, a potential new therapeutic strategy for chemotherapy and the treatment of fibrotic disease

Princeton Docket # 11-2633 The ability to selectively kill quiescent cells could be a powerful tool in medicine. In particular, the ability to kill the quiescent tumor stem cells could be an important addition to our chemotherapeutic repertoire. A better understanding of the transition between quiescent and activated cellular states of fibroblasts...
Published: 12/5/2011   |   Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals

Incorporation of Cisplatin, Carboplatin and Oxalplatin in to a Trinuclear Iron-Platinum Intervalent Charge Transfer Complex: Options for the photochemical Delivery of Cisplatin to Targeted Sites

Princeton University Invention # 08-2484 Cisplatin is a leading chemotherapy agent; however its effectiveness is limited by its severe side effects. Researchers at Princeton University and the University of Medicine and Dentistry New Jersey, Department of Chemistry and Department of Pathology and Laboratory Medicine, respectively have synthesized...
Published: 12/1/2011   |   Inventor(s): Andrew Bocarsly, Patricia Fitzgerald-Bocarsly, Amanda Tricarico, Kate Keets
Keywords(s): cancer/oncology, drug delivery
Category(s): Biotechnology/Pharmaceuticals
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