Incorporation of Cisplatin, Carboplatin and Oxalplatin in to a Trinuclear Iron-Platinum Intervalent Charge Transfer Complex: Options for the photochemical Delivery of Cisplatin to Targeted Sites

Web Published:

Princeton University Invention # 08-2484


Cisplatin is a leading chemotherapy agent; however its effectiveness is limited by its severe side effects.  Researchers at Princeton University and the University of Medicine and Dentistry New Jersey, Department of Chemistry and Department of Pathology and Laboratory Medicine, respectively have synthesized photoreducible complexes incorporating cisplatin.


These complexes contain an intervalent charge transfer band that when irradiated with visible light undergo a charge transfer reaction forming cisplatin.  These complexes can act as masking agents for photoaction therapy as a way to decrease side effects of cisplatin treatment.  Water soluble, photoactivatable complexes have been synthesized and have been tested in vitro to undergo the desired photochemistry. Further in vivo tests are planned.


            The current use of cisplatin is limited by its toxicity in spite of its effectiveness in the treatment of cancer such as testicular, ovarian, and head and neck tumors. This technology may allow for increased efficacy in the use of greater doses of cisplatin without the severe side effects 


Princeton is currently seeking commercial partners for the further development and commercialization of this opportunity. Patent protection is pending.



For more information on Princeton University invention # 08-2484 please contact:


                        Laurie Tzodikov

                        Office of Technology Licensing and Intellectual Property

                        Princeton University

                        4 New South Building

                        Princeton, NJ 08544-0036

                        (609) 258-7256

                        (609) 258-1159 fax



Patent Information:
For Information, Contact:
Laurie Tzodikov
Licensing Associates
Princeton University
Andrew Bocarsly
Patricia Fitzgerald-Bocarsly
Amanda Tricarico
Kate Keets
drug delivery