Search Results - mark+brynildsen

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Metabolite Stimulation to Potentiate Nitrofuran Activity in Tolerant Bacteria

Metabolite Stimulation to Potentiate Antimicrobial Nitrofurantoin Activity in Tolerant BacteriaPrinceton Docket # 20-3641-1 Researchers in the Department of Chemical and Biological Engineering at Princeton University have discovered metabolites that stimulate the susceptibility of antibiotic tolerant bacteria to the antimicrobial agent nitrofurantoin....
Published: 5/4/2022   |   Inventor(s): Mark Brynildsen, Sandra Aedo
Category(s): Biotechnology/Pharmaceuticals

ClpP is a Major Regulator in NO Stressed E Coli

Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies Princeton Docket # 15-3064 Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets host-pathogen interactions,...
Published: 12/21/2022   |   Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Systems Based Method for the Identification of Next Generation Anti-Infective Compositions

Systems based Method for the identification of Next Generation Anti-Infective Compositions Princeton Docket # 13-2870 Researchers in the department of chemical and biological engineering, Princeton University have discovered that engaging futile cycles in microbes increases bacterial death due to oxidative stress by orders of magnitude. Additionally...
Published: 3/30/2022   |   Inventor(s): Mark Brynildsen, Kristin Adolfsen
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics, Computer Science and Information Technology