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Metabolite Stimulation to Potentiate Antimicrobial Nitrofurantoin Activity in Tolerant BacteriaPrinceton Docket # 20-3641-1 Researchers in the Department of Chemical and Biological Engineering at Princeton University have discovered metabolites that stimulate the susceptibility of antibiotic tolerant bacteria to the antimicrobial agent nitrofurantoin....
Published: 10/26/2023
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Inventor(s): Mark Brynildsen, Sandra Aedo
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies
Princeton Docket # 15-3064
Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets
host-pathogen interactions,...
Published: 2/14/2024
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Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Systems based
Method for the identification of Next Generation Anti-Infective
Compositions
Princeton Docket #
13-2870
Researchers
in the department of chemical and biological engineering, Princeton
University
have discovered that engaging futile cycles in microbes increases bacterial
death due to oxidative stress by orders of magnitude. Additionally...
Published: 3/30/2022
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Inventor(s): Mark Brynildsen, Kristin Adolfsen
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics, Computer Science and Information Technology
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