Search Results - olga troyanskaya

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DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequences

DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequencesPrinceton Docket #s 18-3426, 18-3440Researchers at Princeton University and Rockefeller University have collaborated to establish methods for the identification of de novo mutations in the vast noncoding genomic sequence...
Published: 1/14/2019   |   Inventor(s): Jian Zhou, Olga Troyanskaya, Christopher Park, Robert Darnell
Keywords(s):  
Category(s): Computers and Software

Predicting Genomic Variation Effects on Human Gene Transcription

De novo prediction of tissue-specific expression effect and disease risk for every mutation in a human genome - ExpectoPrinceton Docket # 18-3423Sequence-based models, with their scalability and usage of sequence dependencies, enable a new era of mutation analysis at unprecedented scale that can yield a new perspective on human variation in human d...
Published: 11/1/2018   |   Inventor(s): Olga Troyanskaya, Jian Zhou, Chandra Theesfeld
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Computers and Software

Aneuploidy Prediction and Tumor Classification with Heterogeneous Hidden Conditional Random Fields

Princeton University Invention # 09-2491 Cancer signatures are often confounded when looking at tumor morphology, but may be inferred through genetic aberration patterns. Array-based methods provide high-throughput data on genetic copy numbers, but determining the clinically relevant copy number changes and identifying potentiall...
Published: 11/30/2011   |   Inventor(s): Robert Schapire, Olga Troyanskaya, Zafer Barutcuoglu, Edoardo Airoldi
Keywords(s):  
Category(s): Computers and Software, Biotechnology/Pharmaceuticals