Search Results - tom+muir

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Macrocyclic Peptides: Novel Antibiotic Treatment against Staphylococcus Aureus

Macrocyclic Peptides : Novel antibiotic treatment against Staphyloccocus aureusPrinceton Docket # 20-3668Researchers at Princeton University and University of Tokyo have combined mRNA display technology with lipid-nanodisc based selections to identify high affinity ligands of the integral membrane sensor domain of the histidine kinase, AgrC. In S. aureus,...
Published: 5/26/2022   |   Inventor(s): Aishan Zhao, Qian Xie, Tom Muir, Mareike Wiedmann, Hiroaki Suga
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Trackable Quorum-Sensing Molecules for Diagnostic Applications

Princeton Docket # 17-3325-1High quality medical imaging technology has been one of most important developments in clinical care and personalized medicine. Pinpointing the source and cause of disease in a patient allows targeted and optimal treatment, saving time and money. Applying this type of imaging accuracy to the identification of bacterial pathogens...
Published: 12/21/2022   |   Inventor(s): Bonnie Bassler, Howard Stone, Min Kim, Aishan Zhao, Tom Muir
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Inhibiting Quorum Sensing of Bacteria in Healthcare and Industrial Devices Through Conjugation of Anti-Quorum Sensing Molecules to Surfaces

A surface-coating approach for bacteria-free health-care and industrial devices Docket # 15-3136 Bacteria frequently act as members of collectives to create surface-attached communities called biofilms and to synchronously activate the production of virulence factors. Bacterial group behaviors are regulated by a cell-cell communication process called...
Published: 9/8/2022   |   Inventor(s): Min Kim, Aishan Zhao, Howard Stone, Bonnie Bassler, Tom Muir
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry

DNA Barcoding of Designer Mononucleosome and Chromatin Array Libraries for the Profiling of Chromatin Readers, Writers, Erasers, and Modulators Thereof

Chromatin Biochemistry Using Barcoded Nucleosome LibrariesA Versatile Platform to Screen and Identify Epigenetic Signaling Pathways and Drug TargetsPrinceton Docket # 12-2822Researchers at Princeton University have developed a biochemical strategy to decipher chromatin signaling based on the streamlined preparation of DNA-barcoded nucleosome libraries...
Published: 9/12/2022   |   Inventor(s): Tom Muir, Thi Thanh Uyen Nguyen, Manuel Muller
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics