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Macrocyclic Peptides : Novel antibiotic treatment against Staphyloccocus aureusPrinceton Docket # 20-3668Researchers at Princeton University and University of Tokyo have combined mRNA display technology with lipid-nanodisc based selections to identify high affinity ligands of the integral membrane sensor domain of the histidine kinase, AgrC. In S. aureus,...
Published: 5/26/2022
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Inventor(s): Aishan Zhao, Qian Xie, Tom Muir, Mareike Wiedmann, Hiroaki Suga
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket # 17-3325-1High quality medical imaging technology has been one of most important developments in clinical care and personalized medicine. Pinpointing the source and cause of disease in a patient allows targeted and optimal treatment, saving time and money. Applying this type of imaging accuracy to the identification of bacterial pathogens...
Published: 2/14/2024
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Inventor(s): Bonnie Bassler, Howard Stone, Min Kim, Aishan Zhao, Tom Muir
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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A surface-coating approach for bacteria-free health-care and industrial devices Docket # 15-3136 Bacteria frequently act as members of collectives to create surface-attached communities called biofilms and to synchronously activate the production of virulence factors. Bacterial group behaviors are regulated by a cell-cell communication process called...
Published: 9/8/2022
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Inventor(s): Min Kim, Aishan Zhao, Howard Stone, Bonnie Bassler, Tom Muir
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
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Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Chromatin Biochemistry Using Barcoded Nucleosome LibrariesA Versatile Platform to Screen and Identify Epigenetic Signaling Pathways and Drug TargetsPrinceton Docket # 12-2822Researchers at Princeton University have developed a biochemical strategy to decipher chromatin signaling based on the streamlined preparation of DNA-barcoded nucleosome libraries...
Published: 12/28/2023
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Inventor(s): Tom Muir, Thi Thanh Uyen Nguyen, Manuel Muller
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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