scaffold for protein therapeutics
cellular natural product
expression and subsequent purification
to amino acid substitution with epitopes of interest
Pelczer I., Link A.J., Precursor-centric
genome-mining approach for lasso peptide discovery, PNAS, September 18,
2012, Vol. 109, 38, Pg 15223-15228.
Stage of Development
In addition to Astexin-1 the
inventors have identified additional lasso peptides with unique properties
amenable to various applications.
Further testing of these engineered peptides is ongoing
James Link is
an Assistant Professor of Chemical and
Biological Engineering in Princeton University. The
research in the Link group is
highly interdisciplinary and focuses on protein engineering and chemical
biology. One of the major focuses of the Link group
is to apply directed evolution, an experimental algorithm that mimics Darwinian
evolution, to medically relevant proteins. His
research approach is to engineer proteins by utilizing directed evolution to introduce new functions into
The library of protein variants is then screened to
identify those members of the population with the highest levels of function or
activity. Dr. Link has been recognized with an NSF CAREER Award in
2010 and was named a DuPont Young Professor in 2011
and a Sloan Research Fellow in Chemistry in 2013.
is a student in Dr. Link¿s lab and a recipient of a Dodds Honorific
Intellectual Property & Development
protection is pending.
is currently seeking commercial partners for the further development and
commercialization of this opportunity.
Princeton University Office of Technology Licensing ¿ (609)