Description:
Princeton University Invention #
90-0954
The technology
as described in US patent # 5,753,500 relates to a method for producing
substantially pure stocks of recombinant adeno-associated virus, free of the
adeno-associated helper virus found associated with previously available
recombinant AAV. These pure stocks can be used to introduce exogenous genetic
sequences into cells, cell lines, or organisms. In the absence of the
adeno-associated helper virus, the recombinant AAV will remain stably integrated
into cellular DNA. Novel recombinant AAV vectors and adeno-associated
helper viruses are also described which may provide for the increased expression
of the gene product of interest.
Princeton is
currently seeking commercial partners for the further development and
commercialization of this opportunity. Patent protection is
pending.
Publications:
Samulski RD, Chang LS, Shenk T, Helper
Free Stocks of Recombinant Adeno-Associated Viruses: Normal Integration Does Not
Require Viral Gene Expression, Journal of Virology, Sept 1989, p.
3822-3828.
For more information on Princeton
University invention # 90-0954 please contact:
Laurie Tzodikov
Office of Technology Licensing and Intellectual Property
Princeton University
4 New South Building
Princeton, NJ 08544-0036
(609) 258-7256
(609) 258-1159 fax
tzodikov@princeton.edu