Description:
Researchers at
Princeton University have developed a novel method for tracing the neural
circuits of the central nervous system (CNS). Princeton is currently seeking
industrial collaborators to commercialize this technology.
Traditionally,
tracing the neural circuits of the CNS has been limited by the lack of a
suitable method for trans-synaptic tracing. This new method has the capability
of retrograde tracing of specific neural connections across multiple synapses.
This is accomplished by using a recombinant alpha-herpesvirus (pseudorabies
virus; PRV) which is dependent on a Cre-mediated recombination event for
expression of the essential tk gene and green fluorescent protein. By using the
virus and this concept, researchers have the potential to trace any neural
circuit in an animal where transgenic strains can be constructed with any
specific recombinase expressed in neurons.
It is anticipated
that this new technology can be used in the precise delineation of the neural
circuits that respond to varying factors or stimuli, and can lead to a more
complete understanding of the mechanisms responsible for the regulation of human
behavior.
Patent
protection is pending.
For more information please
contact:
William H. Gowen
Office of Technology Licensing and Intellectual
Property
Princeton University
4
New South Building
Princeton, NJ 08544-0036
(609) 258-6762
(609) 258-1159 fax
wgowen@princeton.edu