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Antibiotic Use of Ubonodin and its Derivatives Against Burkholderia Infections Docket# 20-3606Researchers at Princeton University have developed a novel compound that potently kills members of the Burkholderia genus, a notorious family of bacteria that includes multiple human and plant pathogens. Many Burkholderia are resistant to conventional antibiotics,...
Published: 10/26/2024
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Inventor(s): Aaron James Link, Wai Ling Cheung-Lee
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Researchers
at Princeton University, in the Department of Chemical and Biological Engineering,
have engineered a gene cluster which encodes for the biosynthesis of a natural
peptide product called Astexin-1. Astexin-1 is a new member of the lasso peptide
class. Molecules of this class are highly stable, engineerable and may be
utilized as molecular...
Published: 9/13/2022
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Inventor(s): Aaron James Link, Mikhail Maksimov
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Novel Stapled BH3 Peptides
Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple
Cancers
Princeton Docket # 12-2785-1
Researchers in the Department of Chemical and Biological Engineering Princeton
University have identified novel stapled peptides, which have been
engineered to have high cytotoxic activity against several...
Published: 2/17/2023
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Inventor(s): Aaron James Link, Siyan Zhang
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 11-2663
Researchers
at Princeton University created novel peptide derivatives of the antimicrobial
peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent
activity against Gram-negative bacteria. The most potent MccJ25 variants
displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 7/29/2024
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Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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