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Systems and Methods for Analyzing Genetic Data for Assessment of Gene
Regulatory Activity in Disease Prediction, Diagnosis and Treatment
Princeton Docket # 21-3806
Sequence is at the basis of how the genome and its variations shape chromatin organization, regulate gene expression, and impact traits and diseases. Epigenomic profiling efforts have...
Published: 9/29/2025
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Inventor(s): Olga Troyanskaya, Kathleen Chen, Jian Zhou
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Computer Science and Information Technology
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De novo prediction of tissue-specific expression effect and disease risk for every mutation in a human genome - ExpectoPrinceton Docket # 18-3423Sequence-based models, with their scalability and usage of sequence dependencies, enable a new era of mutation analysis at unprecedented scale that can yield a new perspective on human variation in human diseases...
Published: 9/29/2025
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Inventor(s): Olga Troyanskaya, Jian Zhou, Chandra Theesfeld
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Computer Science and Information Technology
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Viricidal Action of inhibition of telomerase action or inhibition of hTERT expression
Princeton Docket: 23-4002-1
Treatment options remain limited for human cytomegalovirus (HCMV), a double-stranded DNA herpesvirus with acute and chronic pathogenic effects as well as the potential to impact cancer progression. While several anti-viral drugs attenuate...
Published: 2/17/2025
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Inventor(s): Daniel Notterman, Chloe Cavanaugh, Thomas Shenk, Maciej Nogalski, Adam Oberstein
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Development of a dual channel detection system for pan-genotypic simultaneous quantification of hepatitis B and delta viruses
Princeton Docket: 24-4106-1
Hepatitis B virus (HBV) remains a major public health problem, causing chronic infection in at least 257 million people who are at risk of developing severe liver disease, including fibrosis,...
Published: 5/14/2025
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Inventor(s): Alexander Ploss, Yongzhen Liu
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Synthetic opine mutualism for enhancement of beneficial plant-microbe interactions
Princeton Docket #23-4015
Description
Inventors in Princeton’s Department of Chemical & Biological Engineering have developed a novel plant-microbe system that improves the persistence of beneficial bacteria at the root-soil interface of crops.
Plant...
Published: 3/5/2024
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Inventor(s): Jonathan Conway, Samuel Eastman
Keywords(s):
Category(s): Energy and CleanTech, Biotechnology/Pharmaceuticals
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DNA Valency Sorting Chromatography for Separating Large Solutes
Princeton Docket # 22-3863
Few technologies are available for analyzing or purifying, in a general way, large solutes labeled with a defined number of molecules. Large solutes could be organic or inorganic nanoparticles, large macromolecules, assemblies of macromolecules or nanoparticles,...
Published: 3/19/2024
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Inventor(s): Haw Yang, Nyssa Emerson
Keywords(s):
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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New biological method for producing semiconductor quantum dots using de novo proteins
Princeton Docket # 22-3839
Quantum dots are an emerging technology with applications in electronics, quantum computing, and biology research. Several methods exist for manufacturing quantum dots, varying in efficacy and end product. Most manufacturing processes...
Published: 2/14/2023
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Inventor(s): Michael Hecht, Sarangan Chari, Leah Spangler
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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MDM-QScreen: A Quantitative Screen for the Assessment of Microbiome Derived Drug Metabolism for Drug Development and Personalized Medicine
Princeton Docket # 20-3681
The human gut microbiome is composed of hundreds of individual species of bacteria and varies greatly between individuals. It has been shown for more than 70 years that bacterial...
Published: 12/20/2022
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Inventor(s): Mohamed Donia, Bahar Javdan, Jaime Lopez
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Low Temperature Plasma Device for Sterilization and Antiviral Applications
Princeton Docket # 20-3699
Researchers at Princeton Plasma Physics Laboratory, Princeton University have designed a flexible dielectric-barrier discharge (DBD) device which produces a uniform, cold plasma for disinfection and sterilization. The device can easily be made into...
Published: 3/26/2025
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Inventor(s): Yevgeny Raitses, Shurik Yatom, Sophia Gershman
Keywords(s): low-temperature plasma
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals, Mechanical Engineering and Robotics
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Metabolomics Explorer (MetEx) for Cryptic Natural Product or Antibiotic Drug DiscoveryPrinceton Docket # 22-3873Researchers in Princeton University’s Department of Chemistry have developed Metabolomics Explorer (MetEx), an application for the analysis of parallel liquid chromatography-coupled mass spectrometry (LC-MS)-based metabolomics data....
Published: 10/5/2022
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Inventor(s): Mohammad Seyedsayamdost, Brett Covington
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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