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Immune System Activators that induce Double-stranded RNA Immune System Activators that Induce Double-stranded RNAPrinceton Docket # 18-3436Immunotherapy is becoming an increasingly popular cancer treatment strategy that harnesses the power of the patient’s own immune system. Researchers at Princeton University have developed synthetic molecules that derepress retroviral elements in the human genome... Published: 8/16/2023   |   Inventor(s): Alisha Chitrakar, Alexei Korennykh Keywords(s):   Category(s): Biotechnology/Pharmaceuticals

A Real-time Biosensor of Antiproliferative Immune Messenger 2-5A for Research, Diagnostics, and High-throughput Screening Princeton Docket # 17-3323-1Princeton researchers have engineered a light emitting reporter to measure the real-time buildup of 2’-5’ linked oligoadenylates (2-5As) biochemically and in live cells using a one-step, high-throughput method.2-5As are produced in stressed human cells that accumulate double stranded RNA (dsRNA). 2-5A serves as... Published: 2/4/2025   |   Inventor(s): Alexei Korennykh, Alisha Chitrakar, Jesse Donovan Keywords(s):   Category(s): Biotechnology/Pharmaceuticals

Sensitive and Accurate PCR Detection of dsRNA Response: Novel Biomarkers for Autoimmune and Infectious Diseases Princeton Docket # 16-3253-1Researchers in the Department of Molecular Biology, Princeton University have identified an innovative qPCR-based method for accurate and specific detection of immune marker RNAs generated by the action of double-stranded RNA (dsRNA) and RNase L. These markers provide one-of-a kind diagnostic tools for the dsRNA response... Published: 2/14/2025   |   Inventor(s): Alexei Korennykh, Jesse Donovan Keywords(s):   Category(s): Biotechnology/Pharmaceuticals

A Novel Research and Diagnostics Tool for Monitoring the Anti-Proliferative Innate Immune Messenger (2-5A) In Vitro and In Vivo Princeton Docket # 16-3188-1Researchers at Princeton University, Department of Molecular Biology, have developed a novel research and diagnostics tool for detection of an intracellular stress signal 2',5'-linked oligoadenylate (2-5A). 2-5A is a small RNA-like signal that activates the human receptor pseudokinase, RNase L. RNase L is a candidate tumor... Published: 8/16/2023   |   Inventor(s): Alexei Korennykh, Alisha Chitrakar, Jesse Donovan Keywords(s):   Category(s): Biotechnology/Pharmaceuticals