Search Results - jesse+donovan

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A Real-time Biosensor of Antiproliferative Immune Messenger 2-5A for Research, Diagnostics, and High-throughput Screening

Princeton Docket # 17-3323-1Princeton researchers have engineered a light emitting reporter to measure the real-time buildup of 2’-5’ linked oligoadenylates (2-5As) biochemically and in live cells using a one-step, high-throughput method.2-5As are produced in stressed human cells that accumulate double stranded RNA (dsRNA). 2-5A serves as...
Published: 12/1/2017   |   Inventor(s): Alexei Korennykh, Alisha Chitrakar, Jesse Donovan
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Sensitive and Accurate PCR Detection of dsRNA Response: Novel Biomarkers for Autoimmune and Infectious Diseases

Princeton Docket # 16-3253-1Researchers in the Department of Molecular Biology, Princeton University have identified an innovative qPCR-based method for accurate and specific detection of immune marker RNAs generated by the action of double-stranded RNA (dsRNA) and RNase L. These markers provide one-of-a kind diagnostic tools for the dsRNA response...
Published: 12/13/2016   |   Inventor(s): Alexei Korennykh, Jesse Donovan
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

A Novel Research and Diagnostics Tool for Monitoring the Anti-Proliferative Innate Immune Messenger (2-5A) In Vitro and In Vivo

Princeton Docket # 16-3188-1Researchers at Princeton University, Department of Molecular Biology, have developed a novel research and diagnostics tool for detection of an intracellular stress signal 2',5'-linked oligoadenylate (2-5A). 2-5A is a small RNA-like signal that activates the human receptor pseudokinase, RNase L. RNase L is a candidate tumor...
Published: 1/6/2016   |   Inventor(s): Alexei Korennykh, Alisha Chitrakar, Jesse Donovan
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals