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Metabolomics Explorer (MetEx) for Cryptic Natural Product or Antibiotic Drug DiscoveryPrinceton Docket # 22-3873Researchers in Princeton University’s Department of Chemistry have developed Metabolomics Explorer (MetEx), an application for the analysis of parallel liquid chromatography-coupled mass spectrometry (LC-MS)-based metabolomics data....
Published: 10/5/2022
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Inventor(s): Mohammad Seyedsayamdost, Brett Covington
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Glycopeptide Antibiotic Combination Therapy Against Clostridial Infections, In Particular, C. difficile
Princeton Docket # 21-3813
Researchers in the Department of Chemistry, Princeton University, and the Department of Chemistry, Emory University, have identified that when combined, vancomycin and keratinicyclin B interact synergistically to inhibit...
Published: 9/5/2023
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Inventor(s): Mohammad Seyedsayamdost, Vasiliki Chioti, Katherine Davis, Kirklin McWhorter
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Tryglysin A and B, Novel, Selective, and Potent Antibacterial Agents Against Streptococcus BacteriaPrinceton Docket # 21-3758Researchers in the Department of Chemistry at Princeton University and the Department of Pharmaceutical Sciences at the University of Illinois at Chicago have identified novel small organic molecules with potent and highly selective...
Published: 6/15/2023
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Inventor(s): Mohammad Seyedsayamdost, Michael Federle, Brett Covington, Leah Bushin, Britta Rued, John Ambrose
Keywords(s):
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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Unlocking Therapeutic Cryptic Metabolites with Bioactivity-HiTESPrinceton
Docket # 20-3645
Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of “cryptic” biosynthetic gene clusters. These clusters can be easily identified bioinformatically, but are at best sparingly expressed under...
Published: 9/5/2023
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Inventor(s): Mohammad Seyedsayamdost, Kyuho Moon
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Guanfacine as an Anti-Virulence Agent in Pseudomonas aeruginosa
Docket# 19-3565-1
Current anti-infective therapies against bacterial pathogens fall in two broad categories: vaccines and antibiotics. While vaccines serve in disease prevention, antibiotics kill pathogens after infection. However, since antibiosis creates a selective pressure for...
Published: 9/19/2023
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Inventor(s): Mohammad Seyedsayamdost, Bethany Okada, Anran Li
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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Keratinimicins and Keratinicyclins-
Novel families of antibacterial and antiviral agents
Docket# 18-3381-1
Researchers at Princeton University have developed a rapid genetics-free method for eliciting and detecting cryptic metabolites. Utilizing this approach, the inventors have activated production of diverse cryptic metabolites and characterized...
Published: 9/5/2023
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Inventor(s): Mohammad Seyedsayamdost, Fei Xu, Yihan Wu, Leah Bushin, Katherine Davis
Keywords(s):
Category(s): Biotechnology/Pharmaceuticals
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