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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of...

Published: 4/15/2025 | Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee

Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic

Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Novel Adjuvant for Improved Immunological Stimulation

Princeton Docket # 14-3007 Researchers in the Department of Molecular Biology at Princeton University have isolated a mutant strain of Escherichia coli that is specifically more resistant to vancomycin than is its wild-type parent. The resistance mutation in this strain alters an enzyme normally involved in LPS biosynthesis causing it to synthesize...

Published: 9/8/2022 | Inventor(s): Thomas Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres

Keywords(s): antibiotics, antibody, immunology, therapeutic, vaccines

Category(s): Biotechnology/Pharmaceuticals

EGFR Inhibitors as Therapeutic Agents for Breast Cancer Bone Metastasis

Princeton University Invention # 09-2509 The involvement of the EGFR signaling pathway in bone metastasis has been implicated by a number of studies. However, the therapeutic significance by targeting EGFR signaling in the tumor-stroma interface has not been evaluated. Researchers in the Molecular Biology Department at Princeton...

Published: 3/30/2022 | Inventor(s): Yibin Kang, Xin Lu

Keywords(s): antibody, cancer/oncology, therapeutic

Category(s): Biotechnology/Pharmaceuticals