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Novel Compounds for Treating Cholera and Other Infections: Potent Agonists of the Quorum Sensing Circuit
Princeton Dockets # 08-2418, 12-2775 & 12-2776 Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening disease. It is estimated that cholera affects 3-5 million people worldwide, and causes 100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and cotrimoxazole have been used to shorten the...