Search Results - small+molecule

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Blocking bacterial infection by inhibiting surface-regulated virulence induction

Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 7/10/2015   |   Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Uses of Hyperthermal Atomic Beam for Low Temperature Diamond Growth

Use of Hyperthermal Atomic Beam for Low Temperature Diamond Growth Princeton Docket #14-2959 High quality diamond films, currently grown only at high substrate temperatures, are desirable for their mechanical hardness, thermal conduction, electrical resistivity, durability and optical transparency. A low temperature process to produce such high quality...
Published: 10/30/2014   |   Inventor(s): Samuel Cohen, Erik Gilson, Winston Chan
Keywords(s): aerospace, materials, small molecule, thin films
Category(s): Ceramics/Material Sciences

Novel Compounds for Treating Cholera and Other Infections: Potent Agonists of the Quorum Sensing Circuit

Princeton Dockets # 08-2418, 12-2775 & 12-2776 Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening disease. It is estimated that cholera affects 3-5 million people worldwide, and causes 100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and cotrimoxazole have been used to shorten the...
Published: 1/31/2012   |   Inventor(s): Martin Semmelhack, Bonnie Bassler, Lark Perez, Megan Bolitho, Matthew Koch, Wai-Leung Ng
Keywords(s): antibiotics, Biotechnology/Pharmaceuticals, small molecule
Category(s): Biotechnology/Pharmaceuticals

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules

Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl...
Published: 12/7/2011   |   Inventor(s): John (Jay) Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals

Inducing apoptosis in quiescent cells, a potential new therapeutic strategy for chemotherapy and the treatment of fibrotic disease

Princeton Docket # 11-2633 The ability to selectively kill quiescent cells could be a powerful tool in medicine. In particular, the ability to kill the quiescent tumor stem cells could be an important addition to our chemotherapeutic repertoire. A better understanding of the transition between quiescent and activated cellular states of fibroblasts...
Published: 12/5/2011   |   Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals

Resistant-Prone Small Molecule Anti-Bacterial Antagonists and Targets for Anti-Bacterial Drug Development

Princeton Docket # 08-2467 & 08-2486 Researchers at Princeton University, Department of Molecular Biology, have identified and synthesized small molecule antagonists that could serve as broad spectrum lead compounds for the disruption of quorum sensing in pathogenic Gram-negative bacteria. In proof of principle experiments, potent antagonist...
Published: 12/1/2011   |   Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals

Compstatin Variants as therapeutic leads for Autoimmune and Inflammatory Disease

Princeton University Invention # 09-2488 The present invention relates to a series of novel analogues to compstatin. Based on experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new analogues show greater binding affinity compared to native compstatin and are therefore potentially more potent drug candidates for diseases related...
Published: 12/1/2011   |   Inventor(s): Christodoulos Floudas (DECEASED) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis
Keywords(s): small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals

Quorum Sensing: Cell-to-Cell Communication of Pathogenic Bacteria

Quorum Sensing is an essential form of intercellular communication used by many types of common bacteria, and many pathogenic bacteria use quorum sensing to attack and invade the human host. Quorum Sensing is used by bacteria to detect a critical cell number, which is the cell population required for pathogenic bacteria to release effective amounts...
Published: 12/1/2011   |   Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals