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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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A Novel Assay for Sirtuin 4 (SIRT4) Lipoamidase Activity and the Activity of the Pyruvate Dehydrogenase Complex
Princeton Docket # 14-3002
A novel assay for measuring the lipoamidase activity of SIRT4 in mammalian cells and tissue samples has been created. A procedure by which the lipoamide cofactor activity can be monitored in mammalian cells has...
Published: 10/28/2022
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Inventor(s): Thomas Shenk, Todd Greco, Ileana Cristea, Rommel Mathias, Adam Oberstein
Keywords(s): biologics, Biotechnology/Pharmaceuticals, genomics/proteomics (software), virology
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Process for Encapsulating Soluble Biologics, Therapeutics, and Imaging AgentsPrinceton Docket # 14-3045The encapsulation and controlled release of peptides and bio-active materials is a significant challenge in the nanoparticle field. Researchers in the Department of Chemical and Biological Engineering at Princeton University have developed a novel...
Published: 3/17/2023
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Inventor(s): Robert Pagels, Robert Prud'homme
Keywords(s): biologics, nanotechnology, research tool
Category(s): Chemistry
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