Search Results - yeast

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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Production of Biofuels, Biomaterials and Sugar Alcohols (Polyols) by a Recombinant Microorganism Expressing Enzymes (Det1 and Pho13) for NADPH Upregulation and Polyol Phosphatase (Ynl010w) for Polyol Phosphatase Dephosphorylation

A New Enzyme and Process for Metabolic Engineering of Production of Sorbitol, Mannitol, Ribitol, Xylitol, Arabitol, Erythritol, and Other Polyols Princeton Docket # 13-2939 Scientists in the Lewis-Sigler Institute, Princeton University have discovered an enzyme which encodes a broad-spectrum, D-stereoisomer-specific sugar alcohol phosphatase,...
Published: 4/28/2014   |   Inventor(s): Yi-Fan Xu, Joshua Rabinowitz, Fabien Letisse, Sarah Johnson
Keywords(s): biofuels, Biotechnology/Pharmaceuticals, Chemistry, metabolic engineering, model organism, yeast
Category(s): Biotechnology/Pharmaceuticals