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Microfluidic Method for Continuous Production of Microfibers with Embedded Droplets
Princeton Docket #14-2982
Fibers are a useful medium for numerous applications, including drug delivery. Current technologies usually make fibers of homogeneous chemical composition or employ axial core-shell structures. To create more complex shapes and compositions,...
Published: 3/30/2022
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Inventor(s): Howard Stone, Janine Nunes, Eujin Um, Tamara Pico
Keywords(s): drug delivery, life science research tools, regenerative medicine, research tool, soft scaffolds, therapeutic, tissue engineering, tissue repair, wound healing
Category(s): Medical Devices/Diagnostics
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/30/2022
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): antibiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies
Princeton Docket # 15-3064
Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets
host-pathogen interactions,...
Published: 2/14/2024
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Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
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Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Novel Cell Line for Hepatitis B Drug Discovery and Research
Princeton Docket # 15-3077
Researchers in the Department of Molecular Biology at Princeton University have developed a novel cell line that is susceptible to hepatitis B and delta infections (HBV, HDV). This cell culture system will allow the viruses and the host factors that modulate...
Published: 2/14/2024
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Inventor(s): Alexander Ploss, Benjamin Winer
Keywords(s): anti-infectives, anti-viral, biomarker/diagnostic, Biotechnology/Pharmaceuticals, infectious disease, life science research tools, research tool, therapeutic, vaccines, virology
Category(s): Biotechnology/Pharmaceuticals
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Noninvasive Mid-infrared in vivo Glucose Sensor
Princeton Docket # 14-2945
Researchers in the Department of Electrical Engineering at Princeton University have developed a novel, noninvasive method to measure blood glucose levels. Development of this noninvasive in vivo glucose sensor may improve the quality of life for the more than 343 million...
Published: 11/9/2022
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Inventor(s): Sabbir Liakat, Claire Gmachl, Anna Michel
Keywords(s): biomarker/diagnostic, diabetes, laser, life science research tools, medical device
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics, Mechanical/Electrical Engineering
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Identification of Novel Isoforms of a Gene and
Their Potential Utility in Diagnostic and Therapeutic Applications in Diseases of
Cellular Motility, Migration, and/or Invasion
Princeton Docket # 13-2929-1
High throughput sequencing approaches have revealed increased complexity of the transcriptome. For example, one gene may give rise to multiple mRNAs...
Published: 3/30/2022
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Inventor(s): Hilary Coller, David Corney
Keywords(s): biomarker/diagnostic, cancer/oncology, life science research tools, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Double-caged
GABA: A Novel Light-activated Probe
as a Neuroscience Research Tool
Princeton Docket #
13-2896-1
Researchers at Princeton University, Departments of Molecular
Biology and Chemistry, have developed a light-activated probe that can be used
as a neuroscience research tool.
Current methods of probing neural...
Published: 11/9/2022
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Inventor(s): Diana Shi, Samuel Wang, Martin Semmelhack
Keywords(s): Biotechnology/Pharmaceuticals, Chemistry, CNS, life science research tools
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Docket # 13-2834-1The market for biological microscopes is greater than $1 billion annually. There is a high demand in the biomedical research field for microscopes which are capable of resolving ever smaller features and faster dynamics in live cells. However, currently available biological microscopes are limited in their ability to follow phenomena...
Published: 12/12/2022
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Inventor(s): Haw Yang, Kevin Welsher
Keywords(s): anti-infectives, anti-viral, Biotechnology/Pharmaceuticals, cancer/oncology, Imaging, life science research tools, microscopy, research tool
Category(s): Medical Devices/Diagnostics, Chemistry, Biotechnology/Pharmaceuticals
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