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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Princeton Docket #
10-2624/2706-1
At the present time
there are few, if any, ways to incorporate halogen atoms selectively into
complex compounds. Halogenated organic compounds play a central role in organic
chemistry, affording important components of a variety of biologically active
molecules as well as pharmacologically active reagents....
Published: 11/27/2024
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Inventor(s): John (Jay) Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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Princeton
Docket # 11-2663
Researchers
at Princeton University created novel peptide derivatives of the antimicrobial
peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent
activity against Gram-negative bacteria. The most potent MccJ25 variants
displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 7/29/2024
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Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Princeton Invention # 07-2351
Cancer metastasis requires the
intricate interactions between cancer cells and the host tissue
microenvironment. Although TGFb signaling pathway has been
implicated in breast cancer metastasis to bone and other target organs, the
temporal-spatial requirement and the in vivo dynamics of TGFb signaling...
Published: 3/30/2022
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Inventor(s): Yibin Kang
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
10-2599
To
date, analysis of chemosensory array (¿artificial nose¿) data has been generally
limited to ¿fingerprinting¿ or ¿pattern recognition¿ methods of data analysis.
These methods do not factor in the physical nature of mixed, cross-inhibitory
signals from multiple ligands. This means that chemosensory arrays based...
Published: 2/14/2024
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Inventor(s): James Broach, Addison Ault, Alex Morozov, Julia Tsitron
Keywords(s): computers/software, defense, medical device, platform technology
Category(s): Biotechnology/Pharmaceuticals, Computer Science and Information Technology
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Princeton Docket #s 12-2718-1, 12-2719-1, 12-2720-1
Homogeneous catalysis with transition metals has transformed the art and science of chemical synthesis. The industrial synthesis of most commodity and fine chemicals, including pharmaceuticals, rely on one or more transition metal catalyzed steps. Traditionally these catalysts are based on precious...
Published: 9/8/2022
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Inventor(s): Paul Chirik, Sebastien Monfette
Keywords(s): catalyst, Chemistry, green tech, platform technology
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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Princeton Docket # 11-2672
Researchers at Princeton
University have developed a novel system for the rapid and specific induction of
individual genes, and upon modification, this system also allows for the rapid
and specific degradation of target proteins. Substantial induction/degradation of
target genes/proteins can be achieved within minutes...
Published: 12/12/2024
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Inventor(s): Sanford Silverman, Robert Mcisaac, David Botstein, Marcus Noyes
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals
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