Search Results - platform+technology

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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules

Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl...
Published: 12/7/2011   |   Inventor(s): John (Jay) Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals

Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/1/2011   |   Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals

A Cell Line and Mouse Model for Studying Pathological TGFß Signaling during Cancer Progression and Metastasis in vivo

Princeton Invention # 07-2351 Cancer metastasis requires the intricate interactions between cancer cells and the host tissue microenvironment. Although TGFb signaling pathway has been implicated in breast cancer metastasis to bone and other target organs, the temporal-spatial requirement and the in vivo dynamics of TGFb signaling...
Published: 12/1/2011   |   Inventor(s): Yibin Kang
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals

A Computational Model for Precisely Decoding Complex Chemical Mixtures with Chemosensory Arrays

Princeton Docket # 10-2599 To date, analysis of chemosensory array (¿artificial nose¿) data has been generally limited to ¿fingerprinting¿ or ¿pattern recognition¿ methods of data analysis. These methods do not factor in the physical nature of mixed, cross-inhibitory signals from multiple ligands. This means that chemosensory arrays based...
Published: 11/30/2011   |   Inventor(s): James Broach, Addison Ault, Alex Morozov, Julia Tsitron
Keywords(s): computers/software, defense, medical device, platform technology
Category(s): Computers and Software, Biotechnology/Pharmaceuticals

Novel Catalysts for Hydrogenation of Olefins: Low Cost, Low Toxicity, and High Enantioselectivity

Princeton Docket #s 12-2718-1, 12-2719-1, 12-2720-1 Homogeneous catalysis with transition metals has transformed the art and science of chemical synthesis. The industrial synthesis of most commodity and fine chemicals, including pharmaceuticals, rely on one or more transition metal catalyzed steps. Traditionally these catalysts are based on precious...
Published: 11/30/2011   |   Inventor(s): Paul Chirik, Sebastien Monfette
Keywords(s): catalyst, Chemistry, green tech, platform technology
Category(s): Chemistry, Biotechnology/Pharmaceuticals

Novel Gene Induction and Protein Degradation Systems: A rapid and specific tool for gene function studies and high throughput screening for target identification and drug discovery

Princeton Docket # 11-2672 Researchers at Princeton University have developed a novel system for the rapid and specific induction of individual genes, and upon modification, this system also allows for the rapid and specific degradation of target proteins. Substantial induction/degradation of target genes/proteins can be achieved within minutes...
Published: 11/22/2011   |   Inventor(s): Sanford Silverman, Robert Mcisaac, David Botstein, Marcus Noyes
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals