Search Results - aaron+james+link

4 Results Sort By:

Antibiotic Use of Ubonodin and its Derivatives Against Burkholderia Infections

Antibiotic Use of Ubonodin and its Derivatives Against Burkholderia Infections Docket# 20-3606Researchers at Princeton University have developed a novel compound that potently kills members of the Burkholderia genus, a notorious family of bacteria that includes multiple human and plant pathogens. Many Burkholderia are resistant to conventional antibiotics,...
Published: 9/13/2022   |   Inventor(s): Aaron James Link, Wai Ling Cheung-Lee
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Novel Lasso Peptides as Molecular Scaffolds for Protein Therapeutics, Molecular Sensors and Probes

Researchers at Princeton University, in the Department of Chemical and Biological Engineering, have engineered a gene cluster which encodes for the biosynthesis of a natural peptide product called Astexin-1. Astexin-1 is a new member of the lasso peptide class. Molecules of this class are highly stable, engineerable and may be utilized as molecular...
Published: 9/13/2022   |   Inventor(s): Aaron James Link, Mikhail Maksimov
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers

Novel Stapled BH3 Peptides Therapeutics for Targeting Mcl-1 as a Potential Treatment for Multiple Cancers Princeton Docket # 12-2785-1 Researchers in the Department of Chemical and Biological Engineering Princeton University have identified novel stapled peptides, which have been engineered to have high cytotoxic activity against several...
Published: 1/20/2023   |   Inventor(s): Aaron James Link, Siyan Zhang
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry
Category(s): Biotechnology/Pharmaceuticals

Novel Variants of Microcin J25 with Increased Potency against Gram Negative Bacteria

Princeton Docket # 11-2663 Researchers at Princeton University created novel peptide derivatives of the antimicrobial peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent activity against Gram-negative bacteria. The most potent MccJ25 variants displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 12/21/2022   |   Inventor(s): Aaron James Link, Si Jia Pan
Keywords(s): antibiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals