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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022
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Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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A target and
screening system for the identification of therapeutic candidates against
secondary viral infections in cancer and immunocompromised
diseases
Docket # 12-2771
Researchers in the
molecular biology department at Princeton University, together with researchers
in the department of microbiology and immunology, School of Medicine, University...
Published: 3/30/2022
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Inventor(s): Danna Hargett, Stephen St. Jeor, Lisa Keyes, Mariana Bego
Keywords(s): anti-viral, cancer/oncology, drug target, human cytomegalovirus, immunocompromised
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 08-2467 & 08-2486
Researchers at
Princeton University, Department of Molecular Biology, have identified and
synthesized small molecule antagonists that could serve as broad spectrum lead
compounds for the disruption of quorum sensing in pathogenic Gram-negative
bacteria. In proof of principle experiments, potent antagonist...
Published: 1/23/2024
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Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 07-2399
Researchers
in the Molecular Biology Department at Princeton University have identified a
recurrent 8q22 genomic gain in poor-prognosis human breast cancers, which
harbors the metastasis gene Metadherin (MTDH). Genomic
gain of 8q22 elevates expression of MTDH,
which is overexpressed in more than 40% of breast cancers...
Published: 9/6/2022
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Inventor(s): Yibin Kang, Guohong Hu
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, drug target, life science venture/early
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals
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Quorum
Sensing is an essential form of intercellular communication used by many types
of common bacteria, and many pathogenic bacteria use quorum sensing to attack
and invade the human host. Quorum Sensing is used by bacteria to detect a
critical cell number, which is the cell population required for pathogenic
bacteria to release effective...
Published: 6/30/2023
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Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
11-2691-1
Using
various in vitro and in vivo xenograft model systems and
clinical samples, researchers in the department of molecular biology, Princeton University
have validated a stage-specific functional role of the miR-200 family to tumor
progression. Current studies
suggest that the miR-200 family may hinder an early step...
Published: 3/30/2022
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Inventor(s): Yibin Kang, Manav Korpal
Keywords(s): biomarker/diagnostic, cancer/oncology, drug target
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals
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Princeton Docket #
11-2669
Although several molecular contributors of bone metastasis have
been identified, effective therapies still await a more comprehensive
understanding of the complex molecular and cellular networks of tumor stromal
interactions in bone metastasis. Researchers in the Department of
Molecular Biology, Princeton
University...
Published: 3/30/2022
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Inventor(s): Yibin Kang, Nilay Sethi
Keywords(s): biomarker/diagnostic, cancer/oncology, drug target, life science venture/early
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals
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