Search Results - drug+target

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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 5/13/2015   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets

Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 1/26/2015   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Target and Screening System for the Identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseaes

A target and screening system for the identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseases Docket # 12-2771 Researchers in the molecular biology department at Princeton University, together with researchers in the department of microbiology and immunology, School of Medicine, University...
Published: 4/25/2012   |   Inventor(s): Danna Hargett, Stephen St. Jeor, Lisa Keyes, Mariana Bego
Keywords(s): anti-viral, cancer/oncology, drug target, human cytomegalovirus, immunocompromised
Category(s): Biotechnology/Pharmaceuticals

Resistant-Prone Small Molecule Anti-Bacterial Antagonists and Targets for Anti-Bacterial Drug Development

Princeton Docket # 08-2467 & 08-2486 Researchers at Princeton University, Department of Molecular Biology, have identified and synthesized small molecule antagonists that could serve as broad spectrum lead compounds for the disruption of quorum sensing in pathogenic Gram-negative bacteria. In proof of principle experiments, potent antagonist...
Published: 12/1/2011   |   Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals

Metadherin: Therapeutic Target for Treating Primary and Metastatic Cancer and Combating Chemoresistance

Princeton Docket # 07-2399 Researchers in the Molecular Biology Department at Princeton University have identified a recurrent 8q22 genomic gain in poor-prognosis human breast cancers, which harbors the metastasis gene Metadherin (MTDH). Genomic gain of 8q22 elevates expression of MTDH, which is overexpressed in more than 40% of breast cancers...
Published: 12/1/2011   |   Inventor(s): Yibin Kang, Guohong Hu
Keywords(s): Biotechnology/Pharmaceuticals, cancer/oncology, drug target, life science venture/early
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals

Quorum Sensing: Cell-to-Cell Communication of Pathogenic Bacteria

Quorum Sensing is an essential form of intercellular communication used by many types of common bacteria, and many pathogenic bacteria use quorum sensing to attack and invade the human host. Quorum Sensing is used by bacteria to detect a critical cell number, which is the cell population required for pathogenic bacteria to release effective amounts...
Published: 12/1/2011   |   Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): antibiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals

Novel Therapeutics for Cancer Metastasis

Princeton Docket # 11-2691-1 Using various in vitro and in vivo xenograft model systems and clinical samples, researchers in the department of molecular biology, Princeton University have validated a stage-specific functional role of the miR-200 family to tumor progression. Current studies suggest that the miR-200 family may hinder an early step...
Published: 12/1/2011   |   Inventor(s): Yibin Kang, Manav Korpal
Keywords(s): biomarker/diagnostic, cancer/oncology, drug target
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals

Jagged1, a marker and therapeutic target for breast cancer bone metastasis

Princeton Docket # 11-2669 Although several molecular contributors of bone metastasis have been identified, effective therapies still await a more comprehensive understanding of the complex molecular and cellular networks of tumor stromal interactions in bone metastasis. Researchers in the Department of Molecular Biology, Princeton University...
Published: 11/4/2011   |   Inventor(s): Yibin Kang, Nilay Sethi
Keywords(s): biomarker/diagnostic, cancer/oncology, drug target, life science venture/early
Category(s): Medical Devices/Diagnostics, Biotechnology/Pharmaceuticals